{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:22Z","timestamp":1792800022946,"version":"4.5.0"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2014_A129"],"award-info":[{"award-number":["2014_A129"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003088","name":"Evangelisches Studienwerk Villigst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coping strategies and their efficacy vary greatly in patients suffering from fibromyalgia syndrome (FMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to identify somatic and psychosocial factors that might contribute to different coping strategies and resilience levels in FMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>Standardized questionnaires were used to assess coping, pain, and psychological variables in a cohort of 156 FMS patients. Quantitative real-time polymerase chain reaction (qRT-PCR) determined gene expression of selected cytokines in white blood cells of 136 FMS patients and 25 healthy controls. Data of skin innervation, functional and structural sensory profiles of peripheral nociceptive nerve fibers of a previous study were included into the statistics. An exploratory factor analysis was used to define variance explaining factors, which were then included into cluster analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>54.9% of the variance was explained by four factors which we termed (1) affective load, (2) coping, (3) pain, and (4) pro-inflammatory cytokines (p &lt; 0.05). Considering differences in the emerged factors, coping strategies, cytokine profiles, and disability levels, 118 FMS patients could be categorized into four clusters which we named \u201cmaladaptive\u201d, \u201cadaptive\u201d, \u201cvulnerable\u201d, and \u201cresilient\u201d (p &lt; 0.05). The adaptive cluster had low scores in disability and in all symptom categories in contrast to the vulnerable cluster, which was characterized by high scores in catastrophizing and disability (p &lt; 0.05). The resilient vs. the maladaptive cluster was characterized by better coping and a less pro-inflammatory cytokine pattern (p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that problem- and emotion-focused coping strategies and an anti-inflammatory cytokine pattern are associated with reduced disability and might promote resilience. Additional personal factors such as low anxiety scores, ability of acceptance, and persistence further favor a resilient phenotype. Individualized therapy should take these factors into account.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0243806","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T13:27:18Z","timestamp":1609162038000},"page":"e0243806","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clustering fibromyalgia patients: A combination of psychosocial and somatic factors leads to resilient coping in a subgroup of fibromyalgia patients"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-0573","authenticated-orcid":true,"given":"Alexandra","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitar","family":"Evdokimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"\u00dc\u00e7eyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"pone.0243806.ref001","doi-asserted-by":"crossref","first-page":"15022","DOI":"10.1038\/nrdp.2015.22","article-title":"Fibromyalgia.","volume":"1","author":"W H\u00e4user","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"pone.0243806.ref002","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10880-018-9543-1","article-title":"Catastrophizing, acceptance, and coping as mediators between pain and emotional distress and disability in fibromyalgia","volume":"25","author":"MJ Lami","year":"2018","journal-title":"J Clin Psychol Med Settings"},{"issue":"4","key":"pone.0243806.ref003","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10067-011-1912-1","article-title":"Delineating psychological and biomedical profiles in a heterogeneous fibromyalgia population using cluster analysis.","volume":"31","author":"BL Loevinger","year":"2012","journal-title":"Clin Rheumatol"},{"issue":"11","key":"pone.0243806.ref004","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s00296-014-3007-1","article-title":"Profiles in fibromyalgia: algometry, auditory evoked potentials and clinical characterization of different subtypes.","volume":"34","author":"Y Tri\u00f1anes","year":"2014","journal-title":"Rheumatol Int"},{"issue":"7","key":"pone.0243806.ref005","first-page":"1255","article-title":"Pain, disability, and physical functioning in subgroups of patients with fibromyalgia","volume":"23","author":"DC Turk","year":"1996","journal-title":"J Rheumatol"},{"issue":"5","key":"pone.0243806.ref006","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/art.1790110511","article-title":"Differential responses by psychosocial subgroups of fibromyalgia syndrome patients to an interdisciplinary treatment.","volume":"11","author":"DC Turk","year":"1998","journal-title":"Arthritis Care Res"},{"issue":"2","key":"pone.0243806.ref007","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ejp.935","article-title":"Identifying fibromyalgia subgroups using cluster analysis: Relationships with clinical variables","volume":"21","author":"Y-R Yim","year":"2017","journal-title":"Eur J Pain"},{"issue":"6","key":"pone.0243806.ref008","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/sjop.12325","article-title":"A comparison of coping strategies in patients with fibromyalgia, chronic neuropathic pain, and pain-free controls.","volume":"57","author":"S Baastrup","year":"2016","journal-title":"Scand J Psychol."},{"issue":"Suppl 1161","key":"pone.0243806.ref009","first-page":"105","article-title":"Fibromyalgia and the concept of resilience","volume":"37","author":"R Casale","year":"2019","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"pone.0243806.ref010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/eip.12726","article-title":"Resilience as a multimodal dynamic process.","volume":"13","author":"A Stainton","year":"2018","journal-title":"Early Interv Psychiatry."},{"key":"pone.0243806.ref011","first-page":"117","volume-title":"Protektive Faktoren der psychisch gesunden Entwicklung junger Menschen: Ein Beitrag zur Kontroverse um saluto- und pathogenetische Ans\u00e4tze.","author":"D Bender","year":"1998"},{"key":"pone.0243806.ref012","first-page":"179","volume-title":"Factors and processes contributing to resilience","author":"KL Kumpfer","year":"2002"},{"key":"pone.0243806.ref013","first-page":"64","volume-title":"The role of ego-control and ego-resiliency in the organization of behavior","author":"JH Block","year":"1980"},{"key":"pone.0243806.ref014","doi-asserted-by":"crossref","first-page":"12","DOI":"10.12688\/wellcomeopenres.13854.1","article-title":"Genetic and environmental contributions to psychological resilience and coping.","volume":"3","author":"LB Navrady","year":"2018","journal-title":"Wellcome Open Res"},{"issue":"2","key":"pone.0243806.ref015","first-page":"75","article-title":"Psychosocial adversity: Risk, resilience & recovery.","volume":"7","author":"M Rutter","year":"1995","journal-title":"J Child Adolesc Ment Health"},{"issue":"7215","key":"pone.0243806.ref016","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"V Krishnan","year":"2008","journal-title":"Nature"},{"issue":"6","key":"pone.0243806.ref017","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopsych.2019.07.012","article-title":"The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span","volume":"86","author":"A Feder","year":"2019","journal-title":"Biol Psychiatry"},{"issue":"8","key":"pone.0243806.ref018","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/art.22026","article-title":"Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain","volume":"54","author":"N \u00dc\u00e7eyler","year":"2006","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"pone.0243806.ref019","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1212\/01.wnl.0000265062.92340.a5","article-title":"Differential expression of cytokines in painful and painless neuropathies","volume":"69","author":"N \u00dc\u00e7eyler","year":"2007","journal-title":"Neurology"},{"key":"pone.0243806.ref020","first-page":"1","article-title":"Reduction of skin innervation is associated with a severe fibromyalgia phenotype","volume":"00","author":"D Evdokimov","year":"2019","journal-title":"Ann Neurol"},{"key":"pone.0243806.ref021","article-title":"Reduced association between dendritic cells and corneal sub-basal nerve fibers in patients with fibromyalgia syndrome.","author":"A Klitsch","year":"2019","journal-title":"J Peripher Nerv Syst."},{"key":"pone.0243806.ref022","doi-asserted-by":"crossref","first-page":"e2421","DOI":"10.7717\/peerj.2421","article-title":"Distinctive personality profiles of fibromyalgia and chronic fatigue syndrome patients.","volume":"4","author":"JN Ablin","year":"2016","journal-title":"PeerJ"},{"issue":"4","key":"pone.0243806.ref023","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpain.2017.11.014","article-title":"Pain and fatigue variability patterns distinguish subgroups of fibromyalgia patients","volume":"19","author":"EJ Bartley","year":"2018","journal-title":"J Pain"},{"issue":"11","key":"pone.0243806.ref024","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/rheumatology\/kex302","article-title":"Adaptation profiles comprising objective and subjective measures in fibromyalgia: the al-\u00c1ndalus project.","volume":"56","author":"F Est\u00e9vez-L\u00f3pez","year":"2017","journal-title":"Rheumatol"},{"issue":"1","key":"pone.0243806.ref025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/2327-6924.12270","article-title":"Heterogeneity in fibromyalgia based upon cognitive and physical performance and psychological symptomology.","volume":"28","author":"BT Follick","year":"2016","journal-title":"J Am Assoc Nurse Pract"},{"issue":"8","key":"pone.0243806.ref026","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/art.38682","article-title":"Subgrouping of patients with rheumatoid arthritis based on pain, fatigue, inflammation, and psychosocial factors.","volume":"66","author":"YC Lee","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"pone.0243806.ref027","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s13075-014-0463-7","article-title":"OMERACT-based fibromyalgia symptom subgroups: an exploratory cluster analysis.","volume":"16","author":"A Vincent","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"pone.0243806.ref028","article-title":"Clustering a large spanish sample of patients with fibromyalgia using the FIQ-R: differences in clinical outcomes, economic costs, inflammatory markers, and gray matter volumes","author":"A P\u00e9rez-Aranda","year":"2018","journal-title":"Pain"},{"issue":"5","key":"pone.0243806.ref029","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The american college of rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity.","volume":"62","author":"F Wolfe","year":"2010","journal-title":"Arthritis Care Res"},{"issue":"Pt 6","key":"pone.0243806.ref030","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1093\/brain\/awt053","article-title":"Small fibre pathology in patients with fibromyalgia syndrome","volume":"136","author":"N \u00dc\u00e7eyler","year":"2013","journal-title":"Brain"},{"key":"pone.0243806.ref031","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1026\/\/0012-1924.47.4.208","article-title":"Allgemeine Depressions-Skala (ADS).","volume":"47","author":"T Meyer","year":"2001","journal-title":"Diagnostica"},{"key":"pone.0243806.ref032","volume-title":"Das State-Trait-Angstinventar: Testmappe mit Handanweisung (Fragebogen STAI-G Form X 1 und Fragebogen STAI-G Form X 2).","author":"L Laux","year":"1981"},{"issue":"5","key":"pone.0243806.ref033","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jpsychores.2007.12.004","article-title":"Cross-cultural adaptation, reliability, and validity of the German version of the Pain Catastrophizing Scale.","volume":"64","author":"K Meyer","year":"2008","journal-title":"J psychosom res"},{"issue":"2","key":"pone.0243806.ref034","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the Childhood Trauma Questionnaire","volume":"27","author":"D Bernstein","year":"2003","journal-title":"Child Abuse Negl"},{"issue":"17","key":"pone.0243806.ref035","first-page":"287","article-title":"Maltreatment in childhood and adolescence: results from a survey of a representative sample of the German population.","volume":"108","author":"W H\u00e4user","year":"2011","journal-title":"Dtsch Arztebl Int"},{"issue":"5","key":"pone.0243806.ref036","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jpain.2005.12.005","article-title":"Translation, cross-cultural adaptation, reliability, and validity of the German version of the Coping Strategies Questionnaire (CSQ-D).","volume":"7","author":"ML Verra","year":"2006","journal-title":"J Pain"},{"key":"pone.0243806.ref037","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1471-2377-11-104","article-title":"A modified score to identify and discriminate neuropathic pain: a study on the German version of the Neuropathic Pain Symptom Inventory (NPSI).","volume":"11","author":"C Sommer","year":"2011","journal-title":"BMC Neurol."},{"key":"pone.0243806.ref038","first-page":"721","article-title":"Diagnostik von Patienten mit orofazialen Schmerzen\u2014Die deutsche Version des -\"Graded Chronic Pain Status\".","volume":"51","author":"J T\u00fcrp","year":"2000","journal-title":"Quintessenz"},{"issue":"8","key":"pone.0243806.ref039","first-page":"1984","article-title":"Validation of a german version of the fibromyalgia impact questionnaire (FIQ-G).","volume":"27","author":"M Offenbaecher","year":"2000","journal-title":"J Rheumatol"},{"issue":"1","key":"pone.0243806.ref040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02959944","article-title":"Der deutsche SF-36 Health Survey \u00dcbersetzung und psychometrische Testung eines krankheits\u00fcbergreifenden Instruments zur Erfassung der gesundheitsbezogenen Lebensqualit\u00e4t","volume":"3","author":"M Bullinger","year":"1995","journal-title":"Journal of Public Health"},{"issue":"4","key":"pone.0243806.ref041","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1026\/0012-1924\/a000205","article-title":"Normierung des SF-12 Version 2.0 zur Messung der gesundheitsbezogenen Lebensqualit\u00e4t in einer deutschen bev\u00f6lkerungsrepr\u00e4sentativen Stichprobe.","volume":"64","author":"M Wirtz","year":"2018","journal-title":"Diagnostica"},{"key":"pone.0243806.ref042","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00415-014-7556-8","article-title":"Differential gene expression of cytokines and neurotrophic factors in nerve and skin of patients with peripheral neuropathies","volume":"262","author":"N \u00dc\u00e7eyler","year":"2015","journal-title":"Neurol"},{"key":"pone.0243806.ref043","first-page":"486","volume":"51","author":"Y Haitovsky","year":"1969","journal-title":"Multicollinearity in Regression Analysis: Comment The Review of Economics and Statistics."},{"key":"pone.0243806.ref044","first-page":"744","volume-title":"Handbook of Psychological Testing","author":"P Kline","year":"1999"},{"issue":"6","key":"pone.0243806.ref045","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/rheumatology\/keq066","article-title":"A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles.","volume":"49","author":"SE Rehm","year":"2010","journal-title":"Rheumatol"},{"issue":"5","key":"pone.0243806.ref046","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/rheumatology\/keu387","article-title":"Psychological profiles in patients with Sj\u00f6gren's syndrome related to fatigue: a cluster analysis.","volume":"54","author":"N van Leeuwen","year":"2015","journal-title":"Rheumatol Int"},{"key":"pone.0243806.ref047","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-6744-1","volume-title":"Cluster analysis in neuropsychological research: Recent applications.","author":"DN Allen","year":"2013"},{"issue":"9","key":"pone.0243806.ref048","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/PSY.0000000000000498","article-title":"Identification and validation of clinically relevant clusters of severe fatigue in rheumatoid arthritis.","volume":"79","author":"N Basu","year":"2017","journal-title":"Psychosom Med."},{"key":"pone.0243806.ref049","unstructured":"Signoret-Genest J. 3D model of rotating FMS cluster defined by factors affective load, coping, pain, and pro-inflammatory cytokines 2019. Available from: https:\/\/drive.google.com\/file\/d\/14r8DXQN1akmftBSYWWFRNv3sZlTQvtpI\/view?usp=sharing."},{"key":"pone.0243806.ref050","unstructured":"Becker LA. Effect Size Calculators 2000 [cited 2019 August 23]. Available from: http:\/\/www.uccs.edu\/lbecker\/."},{"key":"pone.0243806.ref051","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"1988","edition":"2"},{"issue":"2","key":"pone.0243806.ref052","doi-asserted-by":"crossref","first-page":"2055102918807406","DOI":"10.1177\/2055102918807406","article-title":"Interactive effects of pain catastrophizing and mindfulness on pain intensity in women with fibromyalgia","volume":"5","author":"K Dorado","year":"2018","journal-title":"Health Psychol Open"},{"issue":"12","key":"pone.0243806.ref053","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/pm\/pny008","article-title":"Catastrophizing interferes with cognitive modulation of pain in women with fibromyalgia","volume":"19","author":"LD Ellingson","year":"2018","journal-title":"Pain Med"},{"key":"pone.0243806.ref054","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"R Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"pone.0243806.ref055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2018.08.010","article-title":"Resilience and immunity","volume":"74","author":"R Dantzer","year":"2018","journal-title":"Brain Behav Immun"},{"issue":"7","key":"pone.0243806.ref056","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s11064-019-02805-5","article-title":"Possible molecular mediators involved and mechanistic insight into fibromyalgia and associated co-morbidities","volume":"44","author":"L Singh","year":"2019","journal-title":"Neurochem Res"},{"issue":"10","key":"pone.0243806.ref057","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/AJP.0000000000000336","article-title":"Functional status, quality of life, and costs associated with wibromyalgia subgroups: A latent profile analysis","volume":"32","author":"JV Luciano","year":"2016","journal-title":"Clin J Pain"},{"issue":"1","key":"pone.0243806.ref058","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/acr.22626","article-title":"Understanding the association of fatigue with other symptoms of fibromyalgia: development of a cluster model","volume":"68","author":"N Lukkahatai","year":"2016","journal-title":"Arthritis Care Res"},{"key":"pone.0243806.ref059","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/JPR.S100829","article-title":"Identifying the symptom and functional domains in patients with fibromyalgia: results of a cross-sectional Internet-based survey in Italy.","volume":"9","author":"F Salaffi","year":"2016","journal-title":"J Pain Res"},{"issue":"6","key":"pone.0243806.ref060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ejpain.2007.11.004","article-title":"Cognitive appraisal and coping in chronic pain patients","volume":"12","author":"C Ramirez-Maestre","year":"2008","journal-title":"Eur J Pain"},{"issue":"6","key":"pone.0243806.ref061","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/cercor\/bhl052","article-title":"Interactions of pain intensity and cognitive load: the brain stays on task","volume":"17","author":"D Seminowicz","year":"2007","journal-title":"Cereb Cortex"},{"issue":"12","key":"pone.0243806.ref062","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/jclp.10229","article-title":"Dispositional and contextual perspectives on coping: toward an integrative framework.","volume":"59","author":"RH Moos","year":"2003","journal-title":"J Clin Psychol"},{"issue":"2","key":"pone.0243806.ref063","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1037\/1089-2680.1.2.115","article-title":"Meaning in the context of stress and coping.","volume":"1","author":"CL Park","year":"1997","journal-title":"Rev Gen Psychol."},{"issue":"2","key":"pone.0243806.ref064","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1037\/0022-3514.56.2.267","article-title":"Assessing coping strategies: A theoretically based approach.","volume":"56","author":"CS Carver","year":"1989","journal-title":"J Pers Soc Psychol"},{"issue":"2","key":"pone.0243806.ref065","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2466\/pr0.106.2.383-393","article-title":"Illness duration and coping style in chronic fatigue syndrome.","volume":"106","author":"MM Brown","year":"2010","journal-title":"Psychol Rep"},{"key":"pone.0243806.ref066","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1146\/annurev.psych.093008.100352","article-title":"Personality and coping.","volume":"61","author":"CS Carver","year":"2010","journal-title":"Annu Rev Psychol"},{"issue":"2","key":"pone.0243806.ref067","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1037\/0882-7974.2.2.144","article-title":"Everyday problem solving in adulthood and old age.","volume":"2","author":"SW Cornelius","year":"1987","journal-title":"Psychol Aging"},{"issue":"7","key":"pone.0243806.ref068","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.paid.2004.01.010","article-title":"Gender differences in stress and coping styles.","volume":"37","author":"MP Matud","year":"2004","journal-title":"J Individ Differ"},{"key":"pone.0243806.ref069","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jad.2019.05.018","article-title":"Early childhood trauma alters neurological responses to mental stress in patients with coronary artery disease","volume":"254","author":"MT Wittbrodt","year":"2019","journal-title":"J Affect Disord"},{"key":"pone.0243806.ref070","author":"A Rodman","year":"2019","journal-title":"Neurobiological markers of resilience to depression following childhood maltreatment: the role of neural circuits supporting the cognitive control of emotion Biol Psychiatry"},{"key":"pone.0243806.ref071","article-title":"Cognitive strategies to regulate emotions\u2014current evidence and future directions.","author":"N Moyal","year":"2014","journal-title":"Front Psychol."},{"key":"pone.0243806.ref072","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1037\/0022-3514.85.2.348","article-title":"Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.","volume":"85","author":"J Gross","year":"2003","journal-title":"J Pers Soc Psychol"},{"issue":"8","key":"pone.0243806.ref073","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2005-866873","article-title":"Resilienz als protektives Pers\u00f6nlichkeitsmerkmal im Alter.","volume":"55","author":"K Leppert","year":"2005","journal-title":"Psychother Psychosom Med Psychol"},{"issue":"2","key":"pone.0243806.ref074","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11916-010-0095-9","article-title":"Resilience: a new paradigm for adaptation to chronic pain","volume":"14","author":"JA Sturgeon","year":"2010","journal-title":"Curr Pain Headache Rep"},{"issue":"2","key":"pone.0243806.ref075","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2013.10.007","article-title":"A multilevel structural equation modeling analysis of vulnerabilities and resilience resources influencing affective adaptation to chronic pain","volume":"155","author":"JA Sturgeon","year":"2014","journal-title":"Pain"},{"issue":"3","key":"pone.0243806.ref076","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/papt.12185","article-title":"Conceptualizing resilience in adult mental health literature: A systematic review and narrative synthesis.","volume":"92","author":"N Ayed","year":"2018","journal-title":"Psychol 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Prietl","year":"2013","journal-title":"Nutrients"},{"issue":"12","key":"pone.0243806.ref080","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s10067-017-3754-y","article-title":"Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis","volume":"36","author":"WC Yong","year":"2017","journal-title":"Clin Rheumatol"},{"key":"pone.0243806.ref081","article-title":"The impact of a group-based multidisciplinary rehabilitation program on the quality of life in patients with fibromyalgia: results from the QUALIFIBRO study.","author":"H Jacobs","year":"2019","journal-title":"Clin Rheumatol."},{"issue":"10","key":"pone.0243806.ref082","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/acr.20268","article-title":"Tailored cognitive\u2013behavioral therapy and exercise training for high\u2010risk patients with fibromyalgia.","volume":"62","author":"S van Koulil","year":"2010","journal-title":"Arthritis Care 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