{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:23:13Z","timestamp":1789658593203,"version":"4.0.1"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology","award":["2018R1A2A2A05021467"],"award-info":[{"award-number":["2018R1A2A2A05021467"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine the effectiveness of pharmacologic interventions for preventing postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Design<\/jats:title>\n<jats:p>Systematic review and network meta-analysis (NMA).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Data sources<\/jats:title>\n<jats:p>MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Eligibility criteria, participants, and interventions<\/jats:title>\n<jats:p>Randomized clinical trials that investigated the efficacy of pharmacologic interventions in preventing PONV in patients undergoing thyroidectomy were included. The primary endpoints were the incidences of postoperative nausea and vomiting (PONV), postoperative nausea (PON), postoperative vomiting (POV), use of rescue antiemetics, and incidence of complete response in the overall postoperative phases. The secondary endpoints were the same parameters assessed in the early, middle, and late postoperative phases. The surface under the cumulative ranking curve (SUCRA) values and rankograms were used to present the hierarchy of pharmacologic interventions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Results<\/jats:title>\n<jats:p>Twenty-six studies (n = 3,467 patients) that investigated 17 different pharmacologic interventions were included. According to the SUCRA values, the incidence of PONV among the overall postoperative phases was lowest with propofol alone (16.1%), followed by palonosetron (27.5%), and with tropisetron (28.7%). The incidence of PON among the overall postoperative phases was lowest with propofol alone (11.8%), followed by tropisetron and propofol combination (14%), and ramosetron and dexamethasone combination (18.0%). The incidence of POV among the overall postoperative phases was lowest with tropisetron and propofol combination (2.2%), followed by ramosetron and dexamethasone combination (23.2%), and tropisetron alone (37.3%). The least usage of rescue antiemetics among the overall postoperative phases and the highest complete response was observed with tropisetron and propofol combination (3.9% and 96.6%, respectively).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Propofol and tropisetron alone and in combination, and the ramosetron and dexamethasone combination effectively prevented PONV, PON, POV in patients undergoing thyroidectomy, with some heterogeneity observed in this NMA of full-text reports. Their use minimized the need for rescue antiemetics and enhanced the complete response.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec007\">\n<jats:title>Trial registration number<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=100002\" xlink:type=\"simple\">CRD42018100002<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0243865","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T02:51:50Z","timestamp":1610419910000},"page":"e0243865","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pharmacologic interventions for postoperative nausea and vomiting after thyroidectomy: A systematic review and network meta-analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Ye Jin","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-5880","authenticated-orcid":true,"given":"Hyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"issue":"349","key":"pone.0243865.ref001","article-title":"A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"24","author":"MA Puhan","year":"2014","journal-title":"Bmj"},{"issue":"5","key":"pone.0243865.ref002","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0952-8180(97)00069-X","article-title":"Nausea and vomiting following thyroid and parathyroid surgery","volume":"9","author":"JM Sonner","year":"1997","journal-title":"J Clin Anesth"},{"issue":"1","key":"pone.0243865.ref003","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4097\/kjae.2016.69.1.51","article-title":"Effects of intraoperative single bolus fentanyl administration and remifentanil infusion on postoperative nausea and vomiting","volume":"69","author":"H Lim","year":"2016","journal-title":"Korean J Anesthesiol"},{"key":"pone.0243865.ref004","volume-title":"Cochrane Methods","author":"J Higgins","year":"2016"},{"issue":"15","key":"pone.0243865.ref005","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"DF Stroup","year":"2000","journal-title":"Jama"},{"issue":"1","key":"pone.0243865.ref006","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/bja\/83.1.104","article-title":"Postoperative nausea and vomiting in paediatric patients","volume":"83","author":"JBRaMF Watcha","year":"1999","journal-title":"British Journal of Anaesthesia"},{"issue":"3","key":"pone.0243865.ref007","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/eb-2014-101900","article-title":"Addressing missing outcome data in meta-analysis","volume":"17","author":"D Mavridis","year":"2014","journal-title":"Evidence-based mental health"},{"issue":"2","key":"pone.0243865.ref008","first-page":"560","article-title":"The effects of the prophylactic tropisetron-propofol combination on postoperative nausea and vomiting in patients undergoing thyroidectomy under desflurane anesthesia","volume":"73","author":"A Akin","year":"2006","journal-title":"Mount Sinai Journal of Medicine"},{"issue":"4","key":"pone.0243865.ref009","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/bja\/aep209","article-title":"Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery","volume":"103","author":"SI Kim","year":"2009","journal-title":"Br J Anaesth"},{"issue":"10","key":"pone.0243865.ref010","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.287.10.1233","article-title":"Postoperative nausea and vomiting\u2014can it be eliminated?","volume":"287","author":"TJ Gan","year":"2002","journal-title":"Jama"},{"issue":"1","key":"pone.0243865.ref011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/157488608783333934","article-title":"The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery","volume":"3","author":"Y. Fujii","year":"2008","journal-title":"Curr Drug Saf"},{"issue":"4","key":"pone.0243865.ref012","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/bja\/77.4.463","article-title":"Antiemetic effect of subhypnotic doses of propofol after thyroidectomy","volume":"77","author":"P Ewalenko","year":"1996","journal-title":"Br J Anaesth"},{"issue":"4","key":"pone.0243865.ref013","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/0300060513485864","article-title":"Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: a prospective, randomized, double-blind study","volume":"41","author":"WJ Kim","year":"2013","journal-title":"The Journal of international medical research"},{"issue":"5","key":"pone.0243865.ref014","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jclinane.2003.10.001","article-title":"Timing of administration of dolasetron affects dose necessary to prevent postoperative nausea and vomiting","volume":"16","author":"KT Korttila","year":"2004","journal-title":"J Clin Anesth"},{"issue":"1","key":"pone.0243865.ref015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.curtheres.2010.02.002","article-title":"Comparison of ramosetron, dexamethasone, and a combination of ramosetron and dexamethasone for the prevention of postoperative nausea and vomiting in Korean women undergoing thyroidectomy: A double-blind, randomized, controlled study","volume":"71","author":"Y Jeon","year":"2010","journal-title":"Current therapeutic research, clinical and experimental"},{"issue":"2","key":"pone.0243865.ref016","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4097\/kjae.2011.61.2.154","article-title":"The preventative effect of ramosetron on postoperative nausea and vomiting after total thyroidectomy","volume":"61","author":"DC Lee","year":"2011","journal-title":"Korean J Anesthesiol"},{"issue":"6","key":"pone.0243865.ref017","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00268-011-1363-5","article-title":"Combination of dexamethasone and tropisetron before thyroidectomy to alleviate postoperative nausea, vomiting, and pain: randomized controlled trial","volume":"36","author":"H Zhou","year":"2012","journal-title":"World J Surg"},{"issue":"1","key":"pone.0243865.ref018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00268-011-1343-9","article-title":"Dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing thyroidectomy: meta-analysis of randomized controlled trials","volume":"36","author":"CC Chen","year":"2012","journal-title":"World J Surg"},{"issue":"10","key":"pone.0243865.ref019","doi-asserted-by":"crossref","first-page":"e109582","DOI":"10.1371\/journal.pone.0109582","article-title":"The impact of prophylactic dexamethasone on nausea and vomiting after thyroidectomy: a systematic review and meta-analysis","volume":"9","author":"Z Zou","year":"2014","journal-title":"PLoS One"},{"key":"pone.0243865.ref020","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.12659\/MSM.891390","article-title":"Dexamethasone reduces nausea and vomiting but not pain after thyroid surgery: a meta-analysis of randomized controlled trials","volume":"20","author":"B Li","year":"2014","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"issue":"11","key":"pone.0243865.ref021","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"B Hutton","year":"2015","journal-title":"Ann Intern Med"},{"key":"pone.0243865.ref022","first-page":"g7647","article-title":"Preferred reporting items for systematic review and 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medicine"},{"issue":"10","key":"pone.0243865.ref026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"A Chaimani","year":"2013","journal-title":"PLoS One."},{"issue":"2","key":"pone.0243865.ref027","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jrsm.1037","article-title":"mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool","volume":"3","author":"Salanti G. Indirect","year":"2012","journal-title":"Res Synth Methods"},{"issue":"21","key":"pone.0243865.ref028","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1002\/sim.6188","article-title":"A design-by-treatment interaction model for network meta-analysis with random inconsistency effects","volume":"33","author":"D Jackson","year":"2014","journal-title":"Statistics in medicine"},{"issue":"2","key":"pone.0243865.ref029","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jrsm.1045","article-title":"Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression","volume":"3","author":"IR White","year":"2012","journal-title":"Res Synth Methods"},{"issue":"1","key":"pone.0243865.ref030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1467-985X.2008.00552.x","article-title":"A re-evaluation of random-effects meta-analysis","volume":"172","author":"JP Higgins","year":"2009","journal-title":"Journal of the Royal Statistical Society Series A, (Statistics in Society)"},{"issue":"6","key":"pone.0243865.ref031","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/0272989X05282643","article-title":"The interpretation of random-effects meta-analysis in decision models","volume":"25","author":"AE Ades","year":"2005","journal-title":"Medical decision making: an international journal of the Society for Medical Decision Making"},{"key":"pone.0243865.ref032","article-title":"Kirkwood. Essential Medical Statistics. Malden","author":"S Jonathan","year":"2003","journal-title":"Mass.: Blackwell Science"},{"issue":"2","key":"pone.0243865.ref033","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"G Salanti","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"pone.0243865.ref034","doi-asserted-by":"crossref","first-page":"d549","DOI":"10.1136\/bmj.d549","article-title":"Interpretation of random effects meta-analyses","volume":"342","author":"RD Riley","year":"2011","journal-title":"BMJ (Clinical research ed)"},{"key":"pone.0243865.ref035","first-page":"13","article-title":"Study protocol for a randomized, double-blind, placebo-controlled trial of a single preoperative steroid dose to prevent nausea and vomiting after thyroidectomy: The tPONV study","author":"I Tarantino","year":"2013","journal-title":"BMC Anesthesiology"},{"key":"pone.0243865.ref036","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jclinane.2016.08.036","article-title":"Effect of adjunctive dexmedetomidine on postoperative intravenous opioid administration in patients undergoing thyroidectomy in an ambulatory setting","volume":"35","author":"K Long","year":"2016","journal-title":"J Clin Anesth"},{"issue":"10","key":"pone.0243865.ref037","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1046\/j.1365-2346.1999.00564.x","article-title":"Prevention of post-operative nausea and vomiting with combined granisetron and droperidol in women undergoing thyroidectomy.","volume":"16","author":"Y Fujii","year":"1999","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"pone.0243865.ref038","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/bja\/81.4.526","article-title":"Prophylactic antiemetic therapy with granisetron in women undergoing thyroidectomy","volume":"81","author":"Y Fujii","year":"1998","journal-title":"Br J Anaesth"},{"issue":"2","key":"pone.0243865.ref039","first-page":"87","article-title":"Comparison of propranolol and diazepam premedications in patients undergoing thyroidectomy.","volume":"18","author":"U G\u00f6k","year":"2010","journal-title":"Anestezi Dergisi"},{"issue":"41","key":"pone.0243865.ref040","doi-asserted-by":"crossref","first-page":"e5135","DOI":"10.1097\/MD.0000000000005135","article-title":"Effects of remifentanil versus nitrous oxide on postoperative nausea, vomiting, and pain in patients receiving thyroidectomy: Propensity score matching analysis","volume":"95","author":"MK Kim","year":"2016","journal-title":"Medicine"},{"issue":"4","key":"pone.0243865.ref041","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/00000539-200104000-00047","article-title":"Intravenous ketoprofen in thyroid and parathyroid surgery","volume":"92","author":"ER Basto","year":"2001","journal-title":"Anesth Analg"},{"issue":"2","key":"pone.0243865.ref042","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1213\/ANE.0b013e31821d72bc","article-title":"Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy.","volume":"113","author":"JW Song","year":"2011","journal-title":"Anesthesia and Analgesia"},{"issue":"1","key":"pone.0243865.ref043","article-title":"Stepwise tapering of remifentanil at the end of surgery decreased postoperative pain and the need of rescue analgesics after thyroidectomy","volume":"15","author":"SS Han","year":"2015","journal-title":"BMC Anesthesiology"},{"issue":"12","key":"pone.0243865.ref044","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1089\/thy.2008.0007","article-title":"Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac","volume":"18","author":"SY Kim","year":"2008","journal-title":"Thyroid"},{"issue":"5","key":"pone.0243865.ref045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/22201181.2015.1075935","article-title":"Effect of ondansetron on the analgesic efficacy of tramadol used for postoperative analgesia: A randomised controlled study","volume":"21","author":"A Murmu","year":"2015","journal-title":"Southern African Journal of Anaesthesia and Analgesia"},{"issue":"4","key":"pone.0243865.ref046","first-page":"239","article-title":"Effects of different doses of dexmedetomidine on the recovery quality from general anesthesia undergoing thyroidectomy","volume":"26","author":"X Zhao","year":"2014","journal-title":"Chinese Critical Care Medicine"},{"issue":"3","key":"pone.0243865.ref047","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4097\/kjae.2017.70.3.299","article-title":"Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia.","volume":"70","author":"EK Choi","year":"2017","journal-title":"Korean J Anesthesiol"},{"issue":"3","key":"pone.0243865.ref048","doi-asserted-by":"crossref","first-page":"e690","DOI":"10.1097\/01.mjt.0000433939.84373.2d","article-title":"A randomized comparison of remifentanil target-controlled infusion versus dexmedetomidine single-dose administration: A better method for smooth recovery from general sevoflurane anesthesia","volume":"23","author":"JS Park","year":"2016","journal-title":"American Journal of Therapeutics"},{"issue":"5","key":"pone.0243865.ref049","first-page":"UC01","article-title":"Comparison of efficacy of clonidine versus ondansetron for prevention of nausea and vomiting post thyroidectomy: A double blind randomized controlled trial","volume":"9","author":"SNG Shilpa","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"6","key":"pone.0243865.ref050","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/hed.21543","article-title":"Dexamethasone prophylaxis before thyroidectomy to reduce postoperative nausea, pain, and vocal dysfunction: a randomized clinical controlled trial","volume":"33","author":"F Feroci","year":"2011","journal-title":"Head & neck"},{"issue":"1","key":"pone.0243865.ref051","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjoto.2018.10.008","article-title":"Preemptive intravenous ibuprofen application reduces pain and opioid consumption following thyroid surgery","volume":"40","author":"V Mutlu","year":"2019","journal-title":"American journal of otolaryngology"},{"issue":"3","key":"pone.0243865.ref052","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/EJA.0b013e32831c8793","article-title":"Effect of intravenous crystalloid infusion on postoperative nausea and vomiting after thyroidectomy: a prospective, randomized, 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analgesic consumption after thyroid surgery; a prospective, randomized trial","volume":"56","author":"S Doksrod","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3\u20134","key":"pone.0243865.ref065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000346612","article-title":"Dexamethasone effect on postoperative pain and tramadol requirement after thyroidectomy","volume":"91","author":"A Barros","year":"2013","journal-title":"Pharmacology"},{"issue":"5","key":"pone.0243865.ref066","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jamaoto.2013.2821","article-title":"Dexamethasone for the prevention of recurrent laryngeal nerve palsy and other complications after thyroid surgery: a randomized double-blind placebo-controlled trial","volume":"139","author":"M Schietroma","year":"2013","journal-title":"JAMA otolaryngology\u2014head & neck 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thyroidectomy: Combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone","volume":"26","author":"A Tavlan","year":"2006","journal-title":"Clinical Drug Investigation"},{"issue":"2","key":"pone.0243865.ref070","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.otohns.2006.09.013","article-title":"Efficacy of dexamethasone for reducing postoperative nausea and vomiting and analgesic requirements after thyroidectomy","volume":"136","author":"Y Fujii","year":"2007","journal-title":"Otolaryngology\u2014head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery"},{"issue":"3","key":"pone.0243865.ref071","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1067\/mhn.2001.113140","article-title":"Small doses of propofol, droperidol, and metoclopramide for the prevention of postoperative nausea and vomiting after thyroidectomy","volume":"124","author":"Y Fujii","year":"2001","journal-title":"Otolaryngology\u2014Head and Neck Surgery"},{"issue":"1","key":"pone.0243865.ref072","first-page":"200","article-title":"The prophylactic effect of dexamethasone on postoperative nausea and vomiting in women undergoing thyroidectomy: a comparison of droperidol with saline","volume":"89","author":"JJ Wang","year":"1999","journal-title":"Anesth Analg"},{"issue":"6","key":"pone.0243865.ref073","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/00000539-200012000-00019","article-title":"The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: a dose-ranging study.","volume":"91","author":"JJ Wang","year":"2000","journal-title":"Anesth Analg."},{"issue":"6","key":"pone.0243865.ref074","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/SLA.0b013e31818c709a","article-title":"Randomized controlled trial on single dose steroid before thyroidectomy for benign disease to improve postoperative nausea, pain, and vocal function","volume":"248","author":"M Worni","year":"2008","journal-title":"Ann Surg"},{"issue":"5","key":"pone.0243865.ref075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1034\/j.1399-6576.2002.460508.x","article-title":"Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery","volume":"46","author":"R Jokela","year":"2002","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"pone.0243865.ref076","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00000542-198807000-00010","article-title":"Propofol-nitrous oxide versus thiopental-isoflurane-nitrous oxide for general anesthesia","volume":"69","author":"VA Doze","year":"1988","journal-title":"Anesthesiology"},{"issue":"4","key":"pone.0243865.ref077","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00000542-199710000-00010","article-title":"Determination of plasma concentrations of propofol associated with 50% reduction in postoperative nausea","volume":"87","author":"TJ Gan","year":"1997","journal-title":"Anesthesiology"},{"issue":"1","key":"pone.0243865.ref078","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12871-019-0847-y","article-title":"Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in parturient undergoing cesarean section\u2014a randomized control trial","volume":"19","author":"S Kampo","year":"2019","journal-title":"BMC Anesthesiol"},{"issue":"2","key":"pone.0243865.ref079","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00000542-200302000-00036","article-title":"Postoperative nausea and vomiting in regional anesthesia: a review","volume":"98","author":"A Borgeat","year":"2003","journal-title":"Anesthesiology"},{"issue":"3","key":"pone.0243865.ref080","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1476-5381.1988.tb11724.x","article-title":"Effects of the anaesthetic 2,6-diisopropylphenol on synaptic transmission in the rat olfactory cortex slice","volume":"95","author":"GG Collins","year":"1988","journal-title":"British journal of pharmacology"},{"issue":"Suppl 3","key":"pone.0243865.ref081","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/annonc\/4.suppl_3.S15","article-title":"toxicology and human pharmacokinetics of tropisetron","volume":"4","author":"Kutz K. Pharmacology","year":"1993","journal-title":"Ann Oncol"},{"issue":"10","key":"pone.0243865.ref082","first-page":"805","article-title":"Tropisetron for prevention of postoperative nausea and vomiting: a quantitative systematic review","volume":"51","author":"P Kranke","year":"2002","journal-title":"Der Anaesthesist"},{"issue":"5","key":"pone.0243865.ref083","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/bja\/71.5.677","article-title":"Tropisetron for postoperative nausea and vomiting in patients after gynaecological surgery","volume":"71","author":"PJ Zomers","year":"1993","journal-title":"Br J Anaesth"},{"issue":"3","key":"pone.0243865.ref084","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF03011739","article-title":"Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo","volume":"43","author":"M Naguib","year":"1996","journal-title":"Canadian journal of anaesthesia = Journal canadien d'anesthesie"},{"issue":"1","key":"pone.0243865.ref085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0310057X0903700106","article-title":"Tropisetron plus subhypnotic propofol infusion is more effective than tropisetron alone for the prevention of vomiting in children after tonsillectomy","volume":"37","author":"AF Erdem","year":"2009","journal-title":"Anaesth Intensive Care"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T02:57:47Z","timestamp":1610420267000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243865"}},"subtitle":[],"editor":[{"given":"Ivan D.","family":"Florez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0243865","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]}}}