{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:11:45Z","timestamp":1789611105456,"version":"build-2803163510"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","award":["MC_PC_MR\/R019789\/1"],"award-info":[{"award-number":["MC_PC_MR\/R019789\/1"]}],"id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjective<\/jats:title>\nTo describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria.<\/jats:p>\n<\/jats:sec>\n\nStudy design<\/jats:title>\nIn a network of seven secondary and tertiary level neonatal units in Nigeria and Kenya, we captured anonymised data on all admissions <48 hours of age over a 6-month period.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\n2280 newborns were admitted. Mean birthweight was 2.3 kg (SD 0.9); 57.0% (1214\/2128) infants were low birthweight (LBW; <2.5kg) and 22.6% (480\/2128) were very LBW (VLBW; <1.5 kg). Median gestation was 36 weeks (interquartile range 32, 39) and 21.6% (483\/2236) infants were very preterm (gestation <32 weeks). The most common morbidities were jaundice (987\/2262, 43.6%), suspected sepsis (955\/2280, 41.9%), respiratory conditions (817\/2280, 35.8%) and birth asphyxia (547\/2280, 24.0%). 18.7% (423\/2262) newborns died; mortality was very high amongst VLBW (222\/472, 47%) and very preterm infants (197\/483, 40.8%). Factors independently associated with mortality were gestation <28 weeks (adjusted odds ratio 11.58; 95% confidence interval 4.73\u201328.39), VLBW (6.92; 4.06\u201311.79), congenital anomaly (4.93; 2.42\u201310.05), abdominal condition (2.86; 1.40\u20135.83), birth asphyxia (2.44; 1.52\u20133.92), respiratory condition (1.46; 1.08\u20132.28) and maternal antibiotics within 24 hours before or after birth (1.91; 1.28\u20132.85). Mortality was reduced if mothers received a partial (0.51; 0.28\u20130.93) or full treatment course (0.44; 0.21\u20130.92) of dexamethasone before preterm delivery.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nGreater efforts are needed to address the very high burden of illnesses and mortality in hospitalized newborns in sub-Saharan Africa. Interventions need to address priority issues during pregnancy and delivery as well as in the newborn.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0244109","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T18:55:36Z","timestamp":1610650536000},"page":"e0244109","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-729X","authenticated-orcid":true,"given":"Helen M.","family":"Nabwera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olukemi O.","family":"Tongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline E. 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