{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:13:33Z","timestamp":1776370413240,"version":"3.51.2"},"reference-count":113,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Kl-1276\/5 Clinical Research Group 247"],"award-info":[{"award-number":["Kl-1276\/5 Clinical Research Group 247"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>In addition to the typical motor symptoms, a majority of patients suffering from Parkinson\u2019s disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on language skills remains ambiguous.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Method<\/jats:title><jats:p>To elucidate the impact of subthalamic deep brain stimulation on natural language production, we systematically analyzed language samples from fourteen individuals (three female \/ eleven male, average age 66.43 \u00b1 7.53 years) with Parkinson\u2019s disease in the active (ON) versus inactive (OFF) stimulation condition. Significant ON-OFF differences were considered as stimulation effects. To localize their neuroanatomical origin within the subthalamic nucleus, they were correlated with the volume of tissue activated by therapeutic stimulation.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Word and clause production speed increased significantly under active stimulation. These enhancements correlated with the volume of tissue activated within the associative part of the subthalamic nucleus, but not with that within the dorsolateral motor part, which again correlated with motor improvement. Language error rates were lower in the ON vs. OFF condition, but did not correlate with electrode localization. No significant changes in further semantic or syntactic language features were detected in the current study.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>The findings point towards a facilitation of executive language functions occurring rather independently from motor improvement. Given the presumed origin of this stimulation effect within the associative part of the subthalamic nucleus, this could be due to co-stimulation of the prefrontal-subthalamic circuit.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0244148","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T19:10:17Z","timestamp":1609269017000},"page":"e0244148","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson\u2019s 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systematic review and meta-analysis","volume":"29","author":"T Pringsheim","year":"2014","journal-title":"Mov Disord"},{"issue":"2","key":"pone.0244148.ref002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/revneuro-2012-0075","article-title":"The role of the subthalamic nucleus in cognition","volume":"24","author":"DB Weintraub","year":"2013","journal-title":"Rev Neurosci"},{"issue":"3","key":"pone.0244148.ref003","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/brln.1997.1707","article-title":"Subcortical aphasia","volume":"58","author":"SE Nadeau","year":"1997","journal-title":"Brain Lang"},{"issue":"2","key":"pone.0244148.ref004","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0093-934X(85)90085-9","article-title":"Subcortical functions in language: A working model","volume":"25","author":"B Crosson","year":"1985","journal-title":"Brain Lang"},{"issue":"1","key":"pone.0244148.ref005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bandl.2012.10.001","article-title":"Frontal-thalamic circuits associated with language","volume":"126","author":"H Barbas","year":"2013","journal-title":"Brain Lang"},{"issue":"2","key":"pone.0244148.ref006","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/13803395.2010.507185","article-title":"Reduced verbal fluency for proper names in nondemented patients with Parkinson\u2019s disease: A quantitative and qualitative analysis","volume":"33","author":"EM Fine","year":"2011","journal-title":"J Clin Exp Neuropsychol"},{"issue":"4","key":"pone.0244148.ref007","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1076\/jcen.21.4.435.885","article-title":"Lexical, Semantic, and Action Verbal Fluency in Parkinson\u2019s Disease with and without Dementia","volume":"21","author":"AL Piatt","year":"1999","journal-title":"J Clin Exp Neuropsychol (Neuropsychology, Dev Cogn Sect A)"},{"issue":"4","key":"pone.0244148.ref008","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mds.20718","article-title":"Action fluency in Parkinson\u2019s disease: A follow-up study","volume":"21","author":"M Signorini","year":"2006","journal-title":"Mov Disord"},{"issue":"2","key":"pone.0244148.ref009","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1155\/2012\/673610","article-title":"Semantic and phonemic verbal fluency in Parkinson\u2019s disease: Influence of clinical and demographic variables","volume":"25","author":"I Obeso","year":"2012","journal-title":"Behav Neurol"},{"issue":"4","key":"pone.0244148.ref010","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1017\/S1355617704104141","article-title":"Verbal fluency deficits in Parkinson\u2019s disease: A meta-analysis","volume":"10","author":"JD Henry","year":"2004","journal-title":"J Int Neuropsychol Soc"},{"issue":"1","key":"pone.0244148.ref011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0093-934X(88)90059-4","article-title":"Language production in Parkinson\u2019s disease: Acoustic and linguistic considerations","volume":"33","author":"J Illes","year":"1988","journal-title":"Brain Lang"},{"issue":"3","key":"pone.0244148.ref012","first-page":"787","article-title":"Linguistic Complexity, Speech Production, and","volume":"54","author":"B Walsh","year":"2011","journal-title":"Comprehension in Parkinson\u2019s Disease: Behavioral and Physiological Indices. J Speech Lang Hear Res"},{"key":"pone.0244148.ref013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1017\/S0142716411000336","article-title":"Sentence production in Parkinson disease: Effects of conceptual and task complexity","volume":"33","author":"MS Troche","year":"2012","journal-title":"Appl Psycholinguist"},{"issue":"6","key":"pone.0244148.ref014","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1044\/jslhr.4306.1350","article-title":"Spoken Language Production in Huntington\u2019s and Parkinson\u2019s Diseases","volume":"43","author":"LL Murray","year":"2000","journal-title":"J Speech Lang Hear Res"},{"issue":"2","key":"pone.0244148.ref015","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/mds.10306","article-title":"Deficit of verb generation in nondemented patients with Parkinson\u2019s disease","volume":"18","author":"P P\u00e9ran","year":"2003","journal-title":"Mov Disord"},{"issue":"2\u20133","key":"pone.0244148.ref016","first-page":"277","article-title":"Noun Verb Dissociation in Parkinson\u2019s Disease","volume":"48","author":"L. Bertella","year":"2001","journal-title":"Elsevier Sci"},{"issue":"6","key":"pone.0244148.ref017","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/jnnp.2007.118729","article-title":"Effects of subthalamic deep brain stimulation on noun\/verb generation and selection from competing alternatives in Parkinson\u2019s disease","volume":"79","author":"JE Castner","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"01","key":"pone.0244148.ref018","first-page":"31","article-title":"Pragmatic language production deficits in Parkinson\u2019s disease","volume":"02","author":"T Holtgraves","year":"2013","journal-title":"Adv Park Dis"},{"issue":"5","key":"pone.0244148.ref019","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3109\/00207454.2010.550389","article-title":"Pragmatic communication is impaired in parkinson disease","volume":"121","author":"D Hall","year":"2011","journal-title":"Int J Neurosci"},{"issue":"6","key":"pone.0244148.ref020","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00005053-199006000-00003","article-title":"Syntax comprehension deficits in Parkinson\u2019s disease","volume":"178","author":"P Lieberman","year":"1990","journal-title":"J Nerv Ment Dis"},{"issue":"3","key":"pone.0244148.ref021","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jneuroling.2005.11.004","article-title":"Self-paced reading and sentence comprehension in Parkinson\u2019s disease","volume":"19","author":"AJ Angwin","year":"2006","journal-title":"J Neurolinguistics"},{"issue":"10","key":"pone.0244148.ref022","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1212\/WNL.41.10.1620","article-title":"Sentence comprehension and praxis deficits in Parkinson\u2019s disease","volume":"41","author":"M Grossman","year":"1991","journal-title":"Neurology"},{"issue":"5","key":"pone.0244148.ref023","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1212\/01.WNL.0000044398.73241.13","article-title":"Grammatical and resource components of sentence processing in Parkinson\u2019s disease: an fMRI study","volume":"60","author":"M Grossman","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"pone.0244148.ref024","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0093-934X(92)90127-Z","article-title":"Speech production, syntax comprehension, and cognitive deficits in Parkinson\u2019s disease","volume":"43","author":"P Lieberman","year":"1992","journal-title":"Brain Lang"},{"issue":"3","key":"pone.0244148.ref025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bandl.2005.10.011","article-title":"The roles of sequencing and verbal working memory in sentence comprehension deficits in Parkinson\u2019s disease","volume":"97","author":"J Hochstadt","year":"2006","journal-title":"Brain Lang"},{"issue":"3","key":"pone.0244148.ref026","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1155\/1999\/327643","article-title":"Speech Impairment in a Large Sample of Patients with Parkinson\u2019s Disease","volume":"11","author":"AK Ho","year":"1999","journal-title":"Behav Neurol"},{"issue":"16","key":"pone.0244148.ref027","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199810153391603","article-title":"Electrical stimulation of the subthalamic nucleus in advanced Parkinsonian\u2019s disease","volume":"339","author":"P Limousin","year":"1998","journal-title":"N Engl J Med"},{"issue":"8","key":"pone.0244148.ref028","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/mds.27372","article-title":"International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson\u2019s disease","volume":"33","author":"SH Fox","year":"2018","journal-title":"Mov Disord"},{"issue":"Pt 9","key":"pone.0244148.ref029","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/brain\/aww182","article-title":"Brain networks modulated by subthalamic nucleus deep brain stimulation","volume":"139","author":"EA Accolla","year":"2016","journal-title":"Brain"},{"issue":"3","key":"pone.0244148.ref030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2009.09.022","article-title":"Network perspectives on the mechanisms of deep brain stimulation","volume":"38","author":"CC McIntyre","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"1","key":"pone.0244148.ref031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s13311-018-00705-0","article-title":"Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders","volume":"16","author":"WJ Neumann","year":"2019","journal-title":"Neurotherapeutics"},{"key":"pone.0244148.ref032","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0079-6123(08)62678-3","article-title":"Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, \u201cprefrontal\u201d and \u201climbic\u201d functions","volume":"85","author":"G Alexander","year":"1989","journal-title":"Prog Brain Res"},{"issue":"1","key":"pone.0244148.ref033","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/brain\/awx300","article-title":"A human prefrontal-subthalamic circuit for cognitive control","volume":"141","author":"R Kelley","year":"2018","journal-title":"Brain"},{"issue":"11","key":"pone.0244148.ref034","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1523\/JNEUROSCI.4674-12.2013","article-title":"The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: Implications for basal ganglia models and deep brain stimulation","volume":"13","author":"WIA Haynes","year":"2013","journal-title":"J Neurosci"},{"issue":"2","key":"pone.0244148.ref035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0168-0102(02)00027-5","article-title":"Functional significance of the cortico-subthalamo-pallidal \u201chyperdirect\u201d pathway","volume":"43","author":"A Nambu","year":"2002","journal-title":"Neurosci Res"},{"issue":"9","key":"pone.0244148.ref036","first-page":"2655","article-title":"Functional segregation of basal ganglia pathways in Parkinson\u2019s disease","volume":"141","author":"WJ Neumann","year":"2018","journal-title":"Brain"},{"issue":"4","key":"pone.0244148.ref037","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.clinph.2014.10.156","article-title":"The modulatory role of subthalamic nucleus in cognitive functions\u2014A viewpoint","volume":"126","author":"I Rektor","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"pone.0244148.ref038","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/mds.27576","article-title":"Sensorimotor subthalamic stimulation restores risk-reward trade-off in Parkinson\u2019s disease","volume":"34","author":"F Irmen","year":"2019","journal-title":"Mov Disord"},{"issue":"25","key":"pone.0244148.ref039","doi-asserted-by":"crossref","first-page":"10661","DOI":"10.1073\/pnas.0610849104","article-title":"Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior","volume":"104","author":"L Mallet","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0244148.ref040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/ana.21795","article-title":"Stimulation of the subthalamic nucleus and impulsivity: Release your horses","volume":"66","author":"B Ballanger","year":"2009","journal-title":"Ann Neurol"},{"issue":"5854","key":"pone.0244148.ref041","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.1146157","article-title":"Hold your horses: Impulsivity, deep brain stimulation, and medication in Parkinsonism","volume":"318","author":"MJ Frank","year":"2007","journal-title":"Science (80-)"},{"issue":"7","key":"pone.0244148.ref042","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1002\/hbm.22417","article-title":"Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta-analytic connectivity study","volume":"35","author":"JL Manes","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"pone.0244148.ref043","first-page":"256","volume-title":"Aphasia","author":"CW Wallesch","year":"1988"},{"key":"pone.0244148.ref044","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1038\/npjparkd.2016.25","article-title":"Parkinson\u2019s disease as a system-level disorder","author":"D Caligiore","year":"2016","journal-title":"npj Park Dis"},{"issue":"Pt 6","key":"pone.0244148.ref045","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/brain\/123.6.1142","article-title":"The impact of deep brain stimulation on executive function in Parkinson\u2019s disease","volume":"123","author":"M Jahanshahi","year":"2000","journal-title":"Brain"},{"issue":"3","key":"pone.0244148.ref046","doi-asserted-by":"crossref","first-page":"411-(3)","DOI":"10.1212\/WNL.55.3.411","article-title":"Neuropsychological changes between \u201coff\u201d and \u201con\u201d STN or GPi stimulation in Parkinson\u2019s disease","volume":"55","author":"B Pillon","year":"2000","journal-title":"Neurology"},{"issue":"14","key":"pone.0244148.ref047","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.neuropsychologia.2007.06.019","article-title":"Lexical-semantic inhibitory mechanisms in Parkinson\u2019s disease as a function of subthalamic stimulation","volume":"45","author":"JE Castner","year":"2007","journal-title":"Neuropsychologia"},{"issue":"5","key":"pone.0244148.ref048","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/archneur.61.5.697","article-title":"Deep Brain Stimulation of the Subthalamic Nucleus Improves Cognitive Flexibility but Impairs Response Inhibition in Parkinson Disease","volume":"61","author":"K Witt","year":"2004","journal-title":"Arch Neurol"},{"issue":"Pt 12","key":"pone.0244148.ref049","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1093\/brain\/aws273","article-title":"Distinct roles of dopamine and subthalamic nucleus in learning and probabilistic decision making","volume":"35","author":"EJ Coulthard","year":"2012","journal-title":"Brain"},{"issue":"6","key":"pone.0244148.ref050","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3171\/2016.5.JNS16243","article-title":"Speech changes induced by deep brain stimulation of the subthalamic nucleus in Parkinson disease: involvement of the dentatorubrothalamic tract","volume":"126","author":"AJ Fenoy","year":"2017","journal-title":"J Neurosurg"},{"key":"pone.0244148.ref051","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bandl.2015.06.002","article-title":"Subthalamic nucleus stimulation and spontaneous language production in Parkinson\u2019s disease: A double laterality problem","volume":"147","author":"K Batens","year":"2015","journal-title":"Brain Lang"},{"issue":"8","key":"pone.0244148.ref052","article-title":"Subthalamic Nucleus Deep Brain Stimulation Impacts Language in Early Parkinson \u2018 s Disease","volume":"7","author":"L Phillips","year":"2012"},{"issue":"8","key":"pone.0244148.ref053","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.parkreldis.2008.12.003","article-title":"Grammar improvement following deep brain stimulation of the subthalamic and the pedunculopontine nuclei in advanced Parkinson\u2019s disease: A pilot study","volume":"15","author":"S Zanini","year":"2009","journal-title":"Park Relat Disord"},{"issue":"2","key":"pone.0244148.ref054","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13760-015-0546-5","article-title":"The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson\u2019s disease","volume":"116","author":"S Van Lier","year":"2016","journal-title":"Acta Neurol Belg"},{"issue":"3","key":"pone.0244148.ref055","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00001756-200303030-00043","article-title":"Language recovery following subthalamic nucleus stimulation in Parkinson\u2019s disease","volume":"14","author":"S Zanini","year":"2003","journal-title":"Neuroreport"},{"key":"pone.0244148.ref056","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jneuroling.2014.07.003","article-title":"The effects of subthalamic nucleus stimulation on semantic and syntactic performance in spontaneous language production in people with Parkinson\u2019s 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Horn","year":"2017","journal-title":"Ann Neurol"},{"issue":"10","key":"pone.0244148.ref066","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1093\/brain\/awz236","article-title":"Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor","volume":"142","author":"B Al-Fatly","year":"2019","journal-title":"Brain"},{"issue":"1","key":"pone.0244148.ref067","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"BB Avants","year":"2008","journal-title":"Med Image Anal"},{"key":"pone.0244148.ref068","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroimage.2017.05.015","article-title":"Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural 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stimulation","volume":"62","author":"M \u00c5str\u00f6m","year":"2015","journal-title":"IEEE Trans Biomed Eng"},{"issue":"1","key":"pone.0244148.ref072","first-page":"1","article-title":"7 Tesla MRI of the ex vivo human brain at 100 micron resolution","volume":"244","author":"BL Edlow","year":"2019","journal-title":"Sci data."},{"key":"pone.0244148.ref073","article-title":"Movement Disorder Society-Sponsored Revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","author":"CG Goetz","year":"2008","journal-title":"Mov Disord"},{"issue":"8","key":"pone.0244148.ref074","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3109\/02699206.2012.683672","article-title":"Computer-assisted analysis of spontaneous speech: Quantification of basic parameters in aphasic and unimpaired language","volume":"26","author":"K Hussmann","year":"2012","journal-title":"Clin Linguist Phonetics"},{"issue":"4","key":"pone.0244148.ref075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-2006-951756","article-title":"Richtlinien f\u00fcr die transkription mit dem programm ASPA (Aachener Sprachanalyse)","volume":"30","author":"M Grande","year":"2006","journal-title":"Spr Stimme Gehor"},{"key":"pone.0244148.ref076","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/978-3-642-46354-9_19","volume-title":"Perception","author":"MF Garrett","year":"1978"},{"key":"pone.0244148.ref077","doi-asserted-by":"crossref","DOI":"10.36198\/9783838537115","volume-title":"Syntax: Grundlagen und Theorien","author":"C D\u00fcrscheid","year":"2012"},{"issue":"3","key":"pone.0244148.ref078","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1525-1403.2012.00441.x","article-title":"Linguistic testing during ON\/OFF states of electrical stimulation in the associative portion of the subthalamic nucleus","volume":"15","author":"MA Homer","year":"2012","journal-title":"Neuromodulation"},{"key":"pone.0244148.ref079","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuropsychologia.2016.05.028","article-title":"Effects of thalamic deep brain stimulation on spontaneous language production","volume":"89","author":"F Ehlen","year":"2016","journal-title":"Neuropsychologia"},{"issue":"2","key":"pone.0244148.ref080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bandc.2009.08.004","article-title":"Linguistic correlates of asymmetric motor symptom severity in Parkinson\u2019s Disease","volume":"72","author":"T Holtgraves","year":"2010","journal-title":"Brain Cogn"},{"key":"pone.0244148.ref081","first-page":"1","article-title":"The Development and Psychometric Properties of LIWC2007","author":"JW Pennebaker","year":"2007","journal-title":"LIWC2007 Manuel"},{"issue":"4","key":"pone.0244148.ref082","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1044\/jshr.3204.755","article-title":"Analysis of Language-Speech Samples with Salt and Pepper. J Speech","volume":"32","author":"AD Weston","year":"1989","journal-title":"Lang Hear Res"},{"key":"pone.0244148.ref083","unstructured":"Duden. Duden; http:\/\/www.duden.de, last access: 2020-05-22."},{"issue":"1","key":"pone.0244148.ref084","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing.","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"pone.0244148.ref085","first-page":"20","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","edition":"2"},{"key":"pone.0244148.ref086","first-page":"273","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","edition":"2"},{"issue":"7","key":"pone.0244148.ref087","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.neuropsychologia.2013.03.008","article-title":"Stimulation of contacts in ventral but not dorsal subthalamic nucleus normalizes response switching in Parkinson\u2019s disease","volume":"51","author":"I Greenhouse","year":"2013","journal-title":"Neuropsychologia"},{"key":"pone.0244148.ref088","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1093\/brain\/awaa148","article-title":"The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson\u2019s disease","volume":"143","author":"PE Mosley","year":"2020","journal-title":"Brain"},{"key":"pone.0244148.ref089","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bandl.2014.04.002","article-title":"Differential effects of deep brain stimulation on verbal fluency","volume":"134","author":"F Ehlen","year":"2014","journal-title":"Brain Lang"},{"issue":"Suppl 1","key":"pone.0244148.ref090","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroimage.2010.03.068","article-title":"Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency.","volume":"54","author":"A Mikos","year":"2011","journal-title":"Neuroimage"},{"issue":"1\u20132","key":"pone.0244148.ref091","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jns.2009.08.003","article-title":"Relationship between neuropsychological outcome and DBS surgical trajectory and electrode location","volume":"287","author":"MK York","year":"2009","journal-title":"J Neurol Sci"},{"key":"pone.0244148.ref092","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.brs.2017.11.014","article-title":"A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson\u2019s disease","volume":"11","author":"KW Scangos","year":"2018","journal-title":"Brain Stimul"},{"issue":"9","key":"pone.0244148.ref093","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0024589","article-title":"Modulation of human time processing by subthalamic deep brain stimulation","volume":"6","author":"L Wojtecki","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"pone.0244148.ref094","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archneur.63.9.1273","article-title":"Frequency-dependent reciprocal modulation of verbal fluency and motor functions in subthalamic deep brain stimulation","volume":"63","author":"L Wojtecki","year":"2006","journal-title":"Arch Neurol"},{"issue":"10","key":"pone.0244148.ref095","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/scan\/nsx090","article-title":"Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson\u2019s disease","volume":"12","author":"F Irmen","year":"2017","journal-title":"Soc Cogn Affect Neurosci"},{"key":"pone.0244148.ref096","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1212\/01.WNL.0000118202.19098.10","article-title":"Stimulation of STN impairs aspects of cognitive control in PD","volume":"62","author":"T Hershey","year":"2004","journal-title":"Neurology"},{"key":"pone.0244148.ref097","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuropsychologia.2016.09.015","article-title":"Influence of subthalamic deep-brain stimulation on cognitive action control in incentive context","volume":"91","author":"JF Houvenaghel","year":"2016","journal-title":"Neuropsychologia"},{"key":"pone.0244148.ref098","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mds.20374","article-title":"GABAergic interneurons in human subthalamic nucleus","volume":"5","author":"JC L\u00e9vesque","year":"2005","journal-title":"Mov Disord"},{"issue":"2","key":"pone.0244148.ref099","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/02688697.2019.1701630","article-title":"White matter tracts involved by deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease: a connectivity study based on preoperative diffusion tensor imaging tractography","volume":"34","author":"F Vassal","year":"2020","journal-title":"Br J Neurosurg"},{"key":"pone.0244148.ref100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0006-8993(75)90364-9","article-title":"Which elements are excited in electrical stimulation of mammalian central nervous system: A review","volume":"98","author":"JB Ranck","year":"1975","journal-title":"Brain Res"},{"key":"pone.0244148.ref101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2020.00013","article-title":"Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates","volume":"14","author":"A Emmi","year":"2020","journal-title":"Front Neuroanat"},{"key":"pone.0244148.ref102","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3171\/2017.10.JNS171513","article-title":"Microsurgical anatomy of the subthalamic nucleus: Correlating fiber dissection results with 3-T magnetic resonance imaging using neuronavigation","volume":"130","author":"A G\u00fcng\u00f6r","year":"2019","journal-title":"J Neurosurg"},{"key":"pone.0244148.ref103","article-title":"Mapping Go-No-Go performance within the subthalamic nucleus region","author":"T Hershey","year":"2010","journal-title":"Brain"},{"issue":"2","key":"pone.0244148.ref104","doi-asserted-by":"crossref","first-page":"E294","DOI":"10.1093\/neuros\/nyy633","article-title":"Stimulation of the Tractography-Defined Subthalamic Nucleus Regions Correlates With Clinical Outcomes","volume":"85","author":"JM Avecillas-Chasin","year":"2019","journal-title":"Neurosurgery"},{"key":"pone.0244148.ref105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuroscience.2018.03.002","article-title":"Schutter DJLG. The Role of Left Dorsolateral Prefrontal Cortex in Language Processing","volume":"377","author":"J Klaus","year":"2018","journal-title":"Neuroscience"},{"issue":"7","key":"pone.0244148.ref106","first-page":"1819","article-title":"Functional heterogeneity of the supplementary motor area","volume":"26","author":"GH Chung","year":"2005","journal-title":"Am J Neuroradiol"},{"key":"pone.0244148.ref107","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cortex.2014.01.017","article-title":"Neural correlates and network connectivity underlying narrative production and comprehension: A combined fMRI and PET study","volume":"57","author":"NY AbdulSabur","year":"2014","journal-title":"Cortex"},{"issue":"2","key":"pone.0244148.ref108","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00429-018-1810-2","article-title":"A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers","volume":"224","author":"L Labache","year":"2019","journal-title":"Brain Struct Funct"},{"issue":"8","key":"pone.0244148.ref109","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/hbm.24523","article-title":"Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies","volume":"40","author":"M Walenski","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"pone.0244148.ref110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/B978-0-12-397025-1.00211-6","article-title":"Cytoarchitectonics, Receptorarchitectonics, and Network Topology of Language","volume":"2","author":"K Amunts","year":"2015","journal-title":"Brain Mapping: An Encyclopedic Reference"},{"issue":"3","key":"pone.0244148.ref111","first-page":"179","article-title":"Effects of Deep Brain Stimulation on Pausing During Spontaneous Speech in Parkinson\u2019s Disease","volume":"21","author":"JS Ahn","year":"2014","journal-title":"J Med Speech Lang Pathol"},{"issue":"2","key":"pone.0244148.ref112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0093-934X(79)90046-4","article-title":"Hesitation and the production of verbal paraphasias and neologisms in jargon aphasia","volume":"8","author":"B Butterworth","year":"1979","journal-title":"Brain Lang"},{"issue":"11","key":"pone.0244148.ref113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079247","article-title":"Intact lexicon running slowly\u2014Prolonged response latencies in patients with subthalamic DBS and verbal fluency deficits","volume":"8","author":"F Ehlen","year":"2013","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:57:02Z","timestamp":1724147822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244148"}},"subtitle":[],"editor":[{"given":"Allan","family":"Siegel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":113,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0244148","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,29]]}}}