{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:14:17Z","timestamp":1747196057328,"version":"3.40.5"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In addition to breast, ovarian, and pancreatic cancers, <jats:italic>BRCA1\/2<\/jats:italic> genes have been associated with prostate cancer (PC). However, the role of <jats:italic>BRCA1\/2<\/jats:italic>-associated family cancer history (FCH) has remained unexplored in treating these four cancer types as a homogenous pathophysiological group. We aimed to clarify the relationship between <jats:italic>BRCA1\/2<\/jats:italic>-associated FCH and PC, and to assess its relationship with cancer aggressiveness. Patient characteristics, positive family history of <jats:italic>BRCA1\/2<\/jats:italic>-associated cancer, and cancer characteristics (Gleason score, prostate specific antigen level at diagnosis, and clinical tumor stage) were analyzed. Among the 1,985 eligible candidates, 473 (23.83%) patients had adequately detailed FCH, obtained via questionnaire, and were thus included in the study. <jats:italic>BRCA1\/2<\/jats:italic>-associated FCH was observed in 135 (28.54%) patients with PC (68, 14.38%), breast (44, 9.30%), pancreatic (31, 6.55%), or ovarian (8, 1.69%) cancers. <jats:italic>BRCA1\/2<\/jats:italic>-associated FCH was not significantly associated with high Gleason score (\u2265 8). Patients with <jats:italic>BRCA<\/jats:italic>-associated FCH were less likely to present with high clinical tumor stage, and no difference was observed in prostate-specific antigen level, presence of metastatic lesions at diagnosis, or likelihood of high-risk classification between patients with and without <jats:italic>BRCA<\/jats:italic>-associated FCH. This is the first report of <jats:italic>BRCA1\/2<\/jats:italic>-associated FCH in Japanese men, indicating that family history did not affect the severity or aggressiveness of PC.<\/jats:p>","DOI":"10.1371\/journal.pone.0244149","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:56:21Z","timestamp":1608663381000},"page":"e0244149","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between prostate cancer characteristics and BRCA1\/2-associated family cancer history in a Japanese 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