{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:08:54Z","timestamp":1789474134120,"version":"build-2803163510"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Residual cysts are relatively rare inflammatory cysts of the jaws. They are essentially radicular cysts without the presence of the offending dentition. These lesions have the ability to destroy bone within the jaws without any symptoms. Moreover, they can mimic more aggressive cysts and tumours on radiographs. The aim of this study was to describe the clinico-pathological features of residual cysts in order to discern them from other cystic lesions as well as analyse their management and recurrence patterns.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>Sixty-four histopathologically confirmed residual cysts were analysed based on their clinical, radiological and histopathological features. Their management and follow-up were also noted.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The majority of lesions presented in elderly (46.8%), edentulous patients (60.9%) and were most commonly found in the posterior regions of the mandible (51.6%). Clinico-pathological features that aided in their diagnosis included long-standing history with slow growing swelling and presence of well-defined, unilocular cystic lesion associated with previously extracted dentition. Enucleation was a successful method in the management of residual cysts with very low recurrence rate (1.6%). Two patients (3.1%) developed squamous cell carcinoma from the cyst lining.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Residual cysts should be high on the list of differential diagnosis when elderly, edentulous patients present with cystic lesions in the jaws compared to dentate patients (<jats:italic>P<\/jats:italic>&lt;0.01). All lesions should by biopsied and sent for histopathological examination along with radiological correlation as they have the potential to transform into primary intra-osseous squamous cell carcinoma with devastating consequences to the patient.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0244250","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T20:34:44Z","timestamp":1608237284000},"page":"e0244250","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Residual cyst of the jaws: A clinico-pathologic study of this seemingly inconspicuous lesion"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-7038","authenticated-orcid":true,"given":"Fadi","family":"Titinchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Morkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"pone.0244250.ref001","doi-asserted-by":"crossref","first-page":"434","DOI":"10.5001\/omj.2016.87","article-title":"A 10-Year Retrospective Analysis of 64 Cases of Cystic Lesions of the Oral and Maxillofacial Region in a Nigerian Tertiary Hospital","volume":"31","author":"B Fomete","year":"2016","journal-title":"Oman Med J"},{"key":"pone.0244250.ref002","first-page":"1341","article-title":"Residual cysts: A brief literature review","volume":"5","author":"TS Tsvetanov","year":"2016","journal-title":"Int J Med and Dent 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odontogenic cystic lesions in children","volume":"73","author":"DM Allon","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"pone.0244250.ref015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2478\/bjdm-2018-0030","article-title":"Management of Large Residual Cyst in Elderly Patient with Decompression Alone: Case Report","volume":"22","author":"D Torul","year":"2018","journal-title":"Balk J Dent Med"},{"key":"pone.0244250.ref016","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0266-4356(04)00152-4","article-title":"Conservative treatment of large cystic lesions of the mandible: a prospective study of the effect of decompression","volume":"42","author":"G Enislidis","year":"2004","journal-title":"Br J Oral Maxillofac Surg"},{"key":"pone.0244250.ref017","article-title":"Localization of a Peripheral Residual Cyst: Diagnostic Role of CT Scan","author":"A Jamdade","year":"2012","journal-title":"Case Rep 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Bucal"},{"key":"pone.0244250.ref021","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0188-4409(00)00069-2","article-title":"Clinico-pathologic study of odontogenic cysts in a Mexican sample population","volume":"31","author":"C Ledesma-Montes","year":"2000","journal-title":"Arch Med Res"},{"key":"pone.0244250.ref022","first-page":"85","article-title":"Odontogenic cysts: analysis of 2,944 cases in Chile","volume":"12","author":"G Ochsenius","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"pone.0244250.ref023","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4317\/medoral.17088","article-title":"Prevalence and distribution of odontogenic and nonodontogenic cysts in a Turkish population","volume":"17","author":"A A\u00e7ikg\u00f6z","year":"2012","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"pone.0244250.ref024","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2334\/josnusd.51.581","article-title":"Odontogenic cysts: a clinicopathological study of 507 cases","volume":"51","author":"RL Avelar","year":"2009","journal-title":"J Oral Sci"},{"key":"pone.0244250.ref025","first-page":"89","article-title":"Odontogenic cysts. Analysis of 856 cases","volume":"7","author":"A Mosqueda-Taylor","year":"2002","journal-title":"Med Oral"},{"key":"pone.0244250.ref026","first-page":"163","article-title":"A Clinical and Radiographic Study of Residual Cyst of the Jaws","volume":"19","author":"KS Hu","year":"1989","journal-title":"Korean J Oral Maxillofac Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T20:34:52Z","timestamp":1608237292000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244250"}},"subtitle":[],"editor":[{"given":"Essam","family":"Al-Moraissi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0244250","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}