{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:29:14Z","timestamp":1789766954926,"version":"4.0.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most studies in acute myocardial infarction complicated by cardiogenic shock (AMICS) include patients presenting with and without out-of-hospital cardiac arrest (OHCA). The aim was to compare OHCA and non-OHCA AMICS patients in terms of hemodynamics, management in the intensive care unit (ICU) and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From a cohort corresponding to two thirds of the Danish population, all patients with AMICS admitted from 2010\u20132017 were individually identified through patient records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1716 AMICS patients were identified of which 723 (42%) presented with OHCA. A total of 1532 patients survived to ICU admission. At the time of ICU arrival, there were no differences between OHCA and non-OHCA AMICS patients in variables commonly used in the AMICS definition (mean arterial pressure (MAP) (72mmHg vs 70mmHg, p = 0.12), lactate (4.3mmol\/L vs 4.0mmol\/L, p = 0.09) and cardiac output (CO) (4.6L\/min vs 4.4L\/min, p = 0.30)) were observed. However, during the initial days of ICU treatment OHCA patients had a higher MAP despite a lower need for vasoactive drugs, higher CO, SVO2 and lactate clearance compared to non-OHCA patients (p&lt;0.05 for all). In multivariable analysis outcome was similar but cause of death differed significantly with hypoxic brain injury being leading cause in OHCA and cardiac failure in non-OHCA AMICS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OHCA and non-OHCA AMICS patients initially have comparable metabolic and hemodynamic profiles, but marked differences develop between the groups during the first days of ICU treatment. Thus, pooling of OHCA and non-OHCA patients as one clinical entity in studies should be done with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0244294","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T14:44:52Z","timestamp":1608734692000},"page":"e0244294","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Hemodynamic and metabolic recovery in acute myocardial infarction-related cardiogenic shock is more rapid among patients presenting with out-of-hospital cardiac arrest"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-7781","authenticated-orcid":true,"given":"Jakob","family":"Josiassen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Kristian","family":"Lerche Helgestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Kjaergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Frederiksen","family":"Hoejgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Berg","family":"Ravn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0981","authenticated-orcid":true,"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"pone.0244294.ref001","article-title":"Temporal trends in incidence and patient characteristics in cardiogenic shock following acute myocardial infarction from 2010 to 2017: a Danish cohort study","author":"OKL Helgestad","year":"2019","journal-title":"European journal of heart failure"},{"issue":"9","key":"pone.0244294.ref002","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/CIRCULATIONAHA.108.814947","article-title":"Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective","volume":"119","author":"RJ Goldberg","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"pone.0244294.ref003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCOUTCOMES.115.002359","article-title":"Decade-Long Trends (2001\u20132011) in the Incidence and Hospital Death Rates Associated with the In-Hospital Development of Cardiogenic Shock after Acute Myocardial Infarction","volume":"9","author":"RJ Goldberg","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"25","key":"pone.0244294.ref004","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock","volume":"377","author":"H Thiele","year":"2017","journal-title":"The New England journal of medicine"},{"issue":"14","key":"pone.0244294.ref005","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1208410","article-title":"Intraaortic balloon support for myocardial infarction with cardiogenic shock","volume":"367","author":"H Thiele","year":"2012","journal-title":"The New England journal of medicine"},{"issue":"9","key":"pone.0244294.ref006","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock","volume":"341","author":"JS Hochman","year":"1999","journal-title":"The New England journal of medicine"},{"key":"pone.0244294.ref007","first-page":"50","article-title":"Long-term survival in patients presenting with STEMI complicated by out of hospital cardiac arrest","volume":"22","author":"R Samanta","year":"2019","journal-title":"Int J Cardiol Heart Vasc"},{"key":"pone.0244294.ref008","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.resuscitation.2014.11.010","article-title":"Prognostic implication of out-of-hospital cardiac arrest in patients with cardiogenic shock and acute myocardial infarction","volume":"87","author":"S Ostenfeld","year":"2015","journal-title":"Resuscitation"},{"issue":"4","key":"pone.0244294.ref009","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1253\/circj.CJ-16-0125","article-title":"Characteristics and Predictors of Mortality in Patients With Cardiovascular Shock in Japan- Results From the Japanese Circulation Society Cardiovascular Shock Registry","volume":"80","author":"Y Ueki","year":"2016","journal-title":"Circ J"},{"issue":"2","key":"pone.0244294.ref010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/ejhf.646","article-title":"Cardiogenic shock in intensive care units: evolution of prevalence, patient profile, management and outcomes, 1997\u20132012","volume":"19","author":"E Puymirat","year":"2017","journal-title":"European journal of heart failure"},{"key":"pone.0244294.ref011","doi-asserted-by":"crossref","first-page":"A12","DOI":"10.1016\/j.resuscitation.2017.10.013","article-title":"Post-cardiac arrest syndrome: pathological processes, biomarkers and vasopressor support, and potential therapeutic targets","volume":"121","author":"SD Mentzelopoulos","year":"2017","journal-title":"Resuscitation"},{"issue":"11","key":"pone.0244294.ref012","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1007\/s00134-013-3043-4","article-title":"Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort","volume":"39","author":"V Lemiale","year":"2013","journal-title":"Intensive Care Med"},{"issue":"18","key":"pone.0244294.ref013","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"72","author":"K Thygesen","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"pone.0244294.ref014","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13613-018-0459-6","article-title":"Development and performance of a novel vasopressor-driven mortality prediction model in septic shock","volume":"8","author":"S Vallabhajosyula","year":"2018","journal-title":"Ann Intensive Care"},{"issue":"8","key":"pone.0244294.ref015","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"SA Bernard","year":"2002","journal-title":"The New England journal of medicine"},{"issue":"23","key":"pone.0244294.ref016","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest","volume":"369","author":"N Nielsen","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"2","key":"pone.0244294.ref017","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.resuscitation.2008.09.009","article-title":"The impact of therapeutic hypothermia on neurological function and quality of life after cardiac arrest","volume":"80","author":"J Bro-Jeppesen","year":"2009","journal-title":"Resuscitation"},{"issue":"5","key":"pone.0244294.ref018","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/CIRCINTERVENTIONS.114.001556","article-title":"Targeted temperature management at 33 degrees C versus 36 degrees C and impact on systemic vascular resistance and myocardial function after out-of-hospital cardiac arrest: a sub-study of the Target Temperature Management Trial","volume":"7","author":"J Bro-Jeppesen","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"issue":"6","key":"pone.0244294.ref019","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2044.1994.tb03517.x","article-title":"Haemodynamic and oxygen transport effects of propofol infusion in critically ill adults","volume":"49","author":"GR Nimmo","year":"1994","journal-title":"Anaesthesia"},{"issue":"2","key":"pone.0244294.ref020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/2048872612451168","article-title":"Lactate and lactate clearance in acute cardiac care patients","volume":"1","author":"P Attana","year":"2012","journal-title":"European heart journal Acute cardiovascular care"},{"key":"pone.0244294.ref021","article-title":"Risk factors of late cardiogenic shock and mortality in ST-segment elevation myocardial infarction patients","author":"L Obling","year":"2017","journal-title":"European heart journal Acute cardiovascular care"},{"issue":"6","key":"pone.0244294.ref022","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/0002-8703(92)90838-M","article-title":"Mixed venous oxygen saturation in AMI","volume":"123","author":"GR Nimmo","year":"1992","journal-title":"American heart journal"},{"issue":"1","key":"pone.0244294.ref023","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0002-8703(91)90754-6","article-title":"Mixed venous oxygen saturation as a guide to tissue oxygenation and prognosis in patients with acute myocardial infarction","volume":"122","author":"T Sumimoto","year":"1991","journal-title":"American heart journal"},{"issue":"9","key":"pone.0244294.ref024","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1097\/CCM.0000000000000405","article-title":"Lactate clearance is a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review and meta-analysis*","volume":"42","author":"Z Zhang","year":"2014","journal-title":"Crit Care Med"},{"issue":"4","key":"pone.0244294.ref025","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCULATIONAHA.117.032722","article-title":"Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction","volume":"139","author":"G Fuernau","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"pone.0244294.ref026","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/CCM.0000000000000691","article-title":"Hemodynamics and vasopressor support during targeted temperature management at 33 degrees C Versus 36 degrees C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial*","volume":"43","author":"J Bro-Jeppesen","year":"2015","journal-title":"Crit Care Med"},{"issue":"13","key":"pone.0244294.ref027","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCULATIONAHA.110.988725","article-title":"Post cardiac arrest syndrome: a review of therapeutic strategies","volume":"123","author":"D Stub","year":"2011","journal-title":"Circulation"},{"issue":"10124","key":"pone.0244294.ref028","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(18)30315-5","article-title":"Out-of-hospital cardiac arrest: in-hospital intervention strategies","volume":"391","author":"C Hassager","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"1","key":"pone.0244294.ref029","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0735-1097(96)00130-1","article-title":"Myocardial dysfunction after resuscitation from cardiac arrest: an example of global myocardial stunning","volume":"28","author":"KB Kern","year":"1996","journal-title":"Journal of the American College of Cardiology"},{"key":"pone.0244294.ref030","doi-asserted-by":"crossref","first-page":"314796","DOI":"10.1155\/2015\/314796","article-title":"Myocardial Dysfunction and Shock after Cardiac Arrest","volume":"2015","author":"JC Jentzer","year":"2015","journal-title":"Biomed Res Int"},{"issue":"17","key":"pone.0244294.ref031","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.jacc.2019.07.077","article-title":"Cardiogenic Shock Classification to Predict Mortality in the Cardiac Intensive Care Unit","volume":"74","author":"JC Jentzer","year":"2019","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"pone.0244294.ref032","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.annemergmed.2014.12.009","article-title":"Factors Associated With Successful Resuscitation After Out-of-Hospital Cardiac Arrest and Temporal Trends in Survival and Comorbidity","volume":"65","author":"H Soholm","year":"2015","journal-title":"Ann Emerg Med"},{"issue":"6","key":"pone.0244294.ref033","doi-asserted-by":"crossref","first-page":"e005346","DOI":"10.1161\/CIRCINTERVENTIONS.117.005346","article-title":"Temporal Trends in Identification, Management, and Clinical Outcomes After Out-of-Hospital Cardiac Arrest: Insights From the Myocardial Ischaemia National Audit Project Database","volume":"11","author":"T Patterson","year":"2018","journal-title":"Circ Cardiovasc Interv"},{"issue":"9","key":"pone.0244294.ref034","doi-asserted-by":"crossref","first-page":"e006692","DOI":"10.1161\/CIRCOUTCOMES.120.006692","article-title":"Understanding How Cardiac Arrest Complicates the Analysis of Clinical Trials of Cardiogenic Shock","volume":"13","author":"JC Jentzer","year":"2020","journal-title":"Circ Cardiovasc Qual Outcomes"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T14:45:18Z","timestamp":1608734718000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244294"}},"subtitle":[],"editor":[{"given":"Corstiaan","family":"den Uil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0244294","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]}}}