{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:02:16Z","timestamp":1764997336606,"version":"3.40.5"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Few studies demonstrate delayed recovery after exercise in children and adults with heart disease. We assess the recovery patterns of gas exchange parameters and heart rate (HR) in children with repaired Tetralogy of Fallot (rToF) compared to healthy peers and investigate the correlation with ventricular function and QRS duration.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>45 children after rToF and 45 controls performed a maximal incremental cardiopulmonary exercise test. In the subsequent recovery period, patterns of VO<jats:sub>2<\/jats:sub>, VCO<jats:sub>2<\/jats:sub> and HR were analysed. Half-life time (T<jats:sub>1\/2<\/jats:sub>) of the exponential decay and drop per minute (Rec<jats:sub>min<\/jats:sub>) were compared between groups. In the rToF group, correlations were examined between the recovery parameters and QRS-duration and ventricular function, described by fractional shortening (FS) and tricuspid annular plane systolic excursion (TAPSE) measured at baseline prior to exercise.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Recovery of VO<jats:sub>2<\/jats:sub> and VCO<jats:sub>2<\/jats:sub> was delayed in rToF patients, half-life time values were higher compared to controls (T<jats:sub>1\/2<\/jats:sub>VO<jats:sub>2<\/jats:sub> 52.51 \u00b111.29 s vs. 44.31 \u00b1 10.47 s; p = 0.001 and T<jats:sub>1\/2<\/jats:sub>VCO<jats:sub>2<\/jats:sub> 68.28 \u00b1 13.84 s vs. 59.41 \u00b1 12.06 s; p = 0.002) and percentage drop from maximal value was slower at each minute of recovery (p&lt;0.05). Correlations were found with FS (T<jats:sub>1\/2<\/jats:sub>VO<jats:sub>2<\/jats:sub>: r = -0.517; p&lt;0.001; Rec<jats:sub>1min<\/jats:sub>VO<jats:sub>2<\/jats:sub>: r = -0.636, p&lt;0.001; Rec<jats:sub>1min<\/jats:sub>VCO<jats:sub>2<\/jats:sub>: r = -0.373, p = 0.012) and TAPSE (T<jats:sub>1\/2<\/jats:sub>VO<jats:sub>2<\/jats:sub>: r = -0.505; p&lt;0.001; Rec<jats:sub>1min<\/jats:sub>VO<jats:sub>2<\/jats:sub>: r = -0.566, p&lt;0.001; T<jats:sub>1\/2<\/jats:sub>VCO<jats:sub>2<\/jats:sub>: r = -0.466; p = 0.001; Rec<jats:sub>1min<\/jats:sub>VCO<jats:sub>2<\/jats:sub>: r = -0.507, p&lt;0.001), not with QRS-duration. No difference was found in HR recovery between patients and controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Children after rToF show a delayed gas exchange recovery after exercise. This delay correlates to ventricular function, demonstrating its importance in recovery after physical activity.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0244312","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:08:45Z","timestamp":1608318525000},"page":"e0244312","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of the recovery phase after maximal exercise in children with repaired tetralogy of Fallot and the relationship with ventricular function"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-0537","authenticated-orcid":true,"given":"Ilse","family":"Coomans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"De Kinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-1732","authenticated-orcid":true,"given":"Hannah","family":"Van Belleghem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"De Groote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Panzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-6889","authenticated-orcid":true,"given":"Hans","family":"De Wilde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mui\u00f1o Mosquera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Bov\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3736-3628","authenticated-orcid":true,"given":"Thomas","family":"Martens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00ebl","family":"De Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Boone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof","family":"Vandekerckhove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"issue":"9699","key":"pone.0244312.ref001","first-page":"1462","volume":"374","author":"C Apitz","year":"2009","journal-title":"Tetralogy of fallot"},{"key":"pone.0244312.ref002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1172-4-2","article-title":"Tetralogy of Fallot.","volume":"4","author":"F Bailliard","year":"2009","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"pone.0244312.ref003","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.amjcard.2011.02.349","article-title":"Longitudinal exercise capacity 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Their relation to cardiac autonomic nervous activity and intrinsic sinus node dysfunction","volume":"154","author":"H Ohuchi","year":"2007","journal-title":"Am Heart J"},{"issue":"7","key":"pone.0244312.ref026","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/S0735-1097(01)01652-7","article-title":"Heart rate recovery: validation and methodologic issues","volume":"38","author":"K Shetler","year":"2001","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"pone.0244312.ref027","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1249\/MSS.0b013e3181621ec4","article-title":"Determinants of heart rate recovery following exercise in children","volume":"40","author":"TP Singh","year":"2008","journal-title":"Med Sci Sports Exerc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:09:05Z","timestamp":1608318545000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244312"}},"subtitle":[],"editor":[{"given":"Elena G.","family":"Tolkacheva","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0244312","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,12,18]]}}}