{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:45:40Z","timestamp":1787579140313,"version":"build-2736575974"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2015-05111"],"award-info":[{"award-number":["RGPIN-2015-05111"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE-146666"],"award-info":[{"award-number":["MFE-146666"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Women involved in repetitive, fatiguing, jobs develop more neck and\/or shoulder musculoskeletal disorders than men. Sex differences in the pain response to exercise could contribute to the higher prevalence of neck\/shoulder musculoskeletal disorders in women. The <jats:bold>objective<\/jats:bold> of this study was to assess sex differences in pain sensitivity following a fatiguing upper limb task. Relationships between measures of fatigue and of the sensitivity to nociceptive and to non-nociceptive stimulations were also explored.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty healthy adults (15 women) performed a fatiguing repetitive pointing task with their dominant arm. Upper limb electromyography was recorded from the dominant upper trapezius, anterior deltoid and bicep brachii and from the contralateral tibialis anterior. Before and immediately after the repetitive pointing task, pressure pain and light touch sensitivity thresholds were measured over the same muscles.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Electromyographic signs of fatigue were observed only in the anterior deltoid and biceps brachii muscles. Pressure pain thresholds over both muscles increased slightly (effect size \u2264 0.34), but no changes occurred over the upper trapezius and the tibialis anterior. Light touch thresholds increased moderately to importantly after the repetitive pointing task over all four muscles (effect sizes = 0.58 to 0.87). No sex differences were observed in any sensory variable. Moreover, no or weak correlations (r = -0.27 to 0.39) were observed between electromyographical signs of fatigue, light touch threshold and pressure pain threshold variables.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We observed sex-independent effects of a repetitive upper limb task on the sensitivity to painful and to nonpainful stimuli. Moreover, the hypoalgesia induced by the repetitive pointing task was weak and localized, and did not directly correlate with the induced muscle fatigue. Results suggest that fatigue-related changes in the sensitivity to noxious and innocuous stimuli could not explain women\u2019s greater prevalence of neck\/shoulder musculoskeletal disorders.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0244321","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:22:14Z","timestamp":1608319334000},"page":"e0244321","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Similar effects of fatigue induced by a repetitive pointing task on local and remote light touch and pain perception in men and women"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-5899","authenticated-orcid":true,"given":"Jason","family":"Bouffard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey","family":"Pearsall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie N.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"pone.0244321.ref001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2474-13-17","article-title":"Costs of shoulder pain and resource use in primary health care: a cost-of-illness study","volume":"13","author":"L Virta","year":"2012","journal-title":"Sweden. 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A meta-analytic review of the hypoalgesic effects of exercise","volume":"13","author":"KM Naugle","year":"2012","journal-title":"J Pain"},{"issue":"11","key":"pone.0244321.ref009","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1249\/MSS.0b013e31817eeecc","article-title":"Dose response of isometric contractions on pain perception in healthy adults","volume":"40","author":"MK Hoeger Bement","year":"2008","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"pone.0244321.ref010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.clinbiomech.2009.01.010","article-title":"Surface EMG based muscle fatigue evaluation in biomechanics","volume":"24","author":"M Cifrek","year":"2009","journal-title":"Clin Biomech (Bristol, Avon)"},{"key":"pone.0244321.ref011","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jelekin.2015.07.003","article-title":"Adaptations to isolated shoulder fatigue during simulated repetitive work. 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Central mechanisms underlying these two phenomena","volume":"595","author":"LV Lima","year":"2017","journal-title":"J Physiol"},{"key":"pone.0244321.ref014","article-title":"Exercise induced hypoalgesia in pain-free and chronic pain populations: State of the art and future directions","author":"D Rice","year":"2019","journal-title":"J Pain"},{"issue":"3","key":"pone.0244321.ref015","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1589\/jpts.27.551","article-title":"Comparisons of changes in the two-point discrimination test following muscle fatigue in healthy adults","volume":"27","author":"J Han","year":"2015","journal-title":"J Phys Ther Sci"},{"issue":"8","key":"pone.0244321.ref016","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00420-007-0286-9","article-title":"Gender differences in workers with identical repetitive industrial tasks: exposure and musculoskeletal disorders","volume":"81","author":"C Nordander","year":"2008","journal-title":"Int Arch Occ 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Srinivasan","year":"2016","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"pone.0244321.ref023","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/apha.12234","article-title":"Sex differences in human fatigability: mechanisms and insight to physiological responses","volume":"210","author":"SK Hunter","year":"2014","journal-title":"Acta Physiol (Oxf)"},{"issue":"1","key":"pone.0244321.ref024","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13293-018-0175-9","article-title":"Sex differences in kinematic adaptations to muscle fatigue induced by repetitive upper limb movements","volume":"9","author":"J Bouffard","year":"2018","journal-title":"Biol Sex Differ"},{"issue":"4","key":"pone.0244321.ref025","first-page":"338","article-title":"Revision of the Physical Activity Readiness Questionnaire (PAR-Q)","volume":"17","author":"S Thomas","year":"1992","journal-title":"Can J Sport 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movement","volume":"25","author":"K Emery","year":"2010","journal-title":"Clin Biomech (Bristol, Avon)"},{"issue":"12","key":"pone.0244321.ref036","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1111\/j.1460-9568.2011.07902.x","article-title":"Computation of measures of effect size for neuroscience data sets","volume":"34","author":"H Hentschke","year":"2011","journal-title":"Eur J Neurosci"},{"key":"pone.0244321.ref037","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","edition":"2"},{"key":"pone.0244321.ref038","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"D Lakens","year":"2013","journal-title":"Front Psychol"},{"issue":"23","key":"pone.0244321.ref039","doi-asserted-by":"crossref","DOI":"10.21105\/joss.00568","article-title":"Gramm: grammar of graphics plotting in Matlab","volume":"3","author":"P Morel","year":"2018","journal-title":"J Open Source Softw"},{"issue":"6","key":"pone.0244321.ref040","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jelekin.2004.04.003","article-title":"Activation of shoulder muscles in healthy men and women under isometric conditions","volume":"14","author":"C Anders","year":"2004","journal-title":"J Electromyogr Kinesiol"},{"issue":"3","key":"pone.0244321.ref041","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1519\/JSC.0b013e3181a05564","article-title":"Alterations in pain perception after resistance exercise performed in the morning and evening","volume":"23","author":"BC Focht","year":"2009","journal-title":"J Strength Cond Res"},{"issue":"1","key":"pone.0244321.ref042","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/bjsm.32.1.20","article-title":"Perception of pain after resistance exercise","volume":"32","author":"KF Koltyn","year":"1998","journal-title":"Br J Sports Med"},{"issue":"1","key":"pone.0244321.ref043","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13293-019-0253-7","article-title":"Sex differences in perceptual responses to experimental pain before and after an experimental fatiguing arm task","volume":"10","author":"A Otto","year":"2019","journal-title":"Biol Sex Differ"},{"issue":"1","key":"pone.0244321.ref044","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1249\/MSS.0b013e3182a05de8","article-title":"Pain relief after isometric exercise is not task-dependent in older men and women","volume":"46","author":"KJ Lemley","year":"2014","journal-title":"Med Sci Sports 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