{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:30:46Z","timestamp":1778938246827,"version":"3.51.4"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI19C0052"],"award-info":[{"award-number":["HI19C0052"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A4A1028155"],"award-info":[{"award-number":["NRF-2019R1A4A1028155"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Aims<\/jats:title><jats:p>We explored the association between influenza epidemic and suicide mortality rates in a large population using a time-series regression of 13-year mortality data in South Korea.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Weekly suicide mortalities and influenza-like illness (ILI) were analyzed using time series regression. Regression coefficient for suicide mortality based on percentage change of ILI was calculated using a quasi-Poisson regression. Non-linear distributed lag models with quadratic function up to 24 weeks were constructed.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The association between ILI and suicide mortality increased significantly up to 8 weeks post-influenza diagnosis. A significant positive association between ILI and suicide mortality was observed from 2009, when a novel influenza A(H1N1)pdm09 virus provoked a worldwide pandemic. No meaningful association between these factors was observed before 2009.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>There was a significant positive relationship between ILI and suicide mortality after 2009, when a novel influenza A(H1N1)pdm09 virus provoked a worldwide pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0244596","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T21:52:00Z","timestamp":1613166720000},"page":"e0244596","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fluctuations in influenza-like illness epidemics and suicide mortality: A time-series regression of 13-year mortality data in South Korea"],"prefix":"10.1371","volume":"16","author":[{"given":"Sun Jae","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Shil","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-2955","authenticated-orcid":true,"given":"Jin-Ha","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"issue":"3","key":"pone.0244596.ref001","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3201\/eid1603.091699","article-title":"Neurologic manifestations of pandemic (H1N1) 2009 virus infection","volume":"16","author":"S Kitcharoen","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"pone.0244596.ref002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2015.12.005","article-title":"The risk of new onset depression in association with influenza\u2014A population-based observational study","volume":"53","author":"D Bornand","year":"2016","journal-title":"Brain Behav Immun"},{"issue":"1\u20132","key":"pone.0244596.ref003","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jad.2011.12.037","article-title":"Does depression lead to influenza?\u2014A systematic literature analysis","volume":"138","author":"D Gharbawy","year":"2012","journal-title":"Journal of affective disorders"},{"issue":"1","key":"pone.0244596.ref004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.24304\/kjcp.2019.29.1.56","article-title":"Psychiatric Symptoms after Taking Oseltamivir in a Child and Its Causality Assessment","volume":"29","author":"P Son","year":"2019","journal-title":"Korean J Clin Pharm"},{"issue":"6","key":"pone.0244596.ref005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4168\/aard.2017.5.6.320","article-title":"Prevalence of respiratory virus infection with regard to age, sex, and seasonality factors: A single center experience against children hospitalized during the 10 years","volume":"5","author":"SJ Lee","year":"2017","journal-title":"Allergy Asthma Respir Dis"},{"key":"pone.0244596.ref006","doi-asserted-by":"crossref","first-page":"e2017033","DOI":"10.4178\/epih.e2017033","article-title":"Infectious disease-related laws: prevention and control measures","volume":"39","author":"M. 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