{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:30:26Z","timestamp":1793759426615,"version":"4.6.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>While it is well established that skin disease places significant psychosocial burden on a patient\u2019s wellbeing, its effects have rarely been examined in Asian populations.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>Evaluate the psychosocial burden of skin disease among community-dwelling adults in Singapore.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study included 1510 participants interviewed on their history of thirteen skin diseases. The Patient Health Questionnaire (PHQ-9), Lubben Social Network Scale-6 (LSNS-6), University of California Los Angeles (UCLA) Loneliness Scale, and European Quality of Life-5 Dimensions- 5 Level (EQ-5D-5L) were used as measures for depressive symptoms, social isolation, loneliness and quality of life respectively. Multiple linear regression analysis was used to examine the association of skin diseases with each of the four measured outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Results<\/jats:title><jats:p>Participants with skin diseases reported significantly higher PHQ-9 and UCLA Loneliness scale scores, and lower LSNS-6 and EQ-5D-5L scores when compared to their healthy counterparts. The presence of skin disease was positively associated with depressive symptoms (B = 0.40, SE = 0.11), and negatively associated with quality of life (B = -0.03, SE = 0.01). As disease severity was not evaluated in this study, we were unable to ascertain the associations between disease severity and measured outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Conclusion<\/jats:title><jats:p>Participants with skin diseases were more likely to have depressive symptoms, social isolation, loneliness and lower quality of life. Unemployed, single and elderly patients were at higher risk of developing depressive symptoms. More emphasis should be placed on the psychosocial aspect of care to reduce the burden of skin disease. Some considerations include monitoring patients for mood-related changes and implementing early psychosocial interventions.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0244765","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T20:13:02Z","timestamp":1609445582000},"page":"e0244765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Psychosocial impact of skin diseases: A population-based study"],"prefix":"10.1371","volume":"15","author":[{"given":"Yik Weng","family":"Yew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-0994","authenticated-orcid":true,"given":"Amanda Hui Yu","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wei","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bee Hoon","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"issue":"3","key":"pone.0244765.ref001","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s13671-017-0192-7","article-title":"Global Burden of Skin Disease: Inequities and Innovations","volume":"6","author":"D Seth","year":"2017","journal-title":"Curr Dermatol Rep"},{"issue":"6","key":"pone.0244765.ref002","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.12968\/hmed.2017.78.6.C82","article-title":"Psychosocial morbidity in skin disease","volume":"78","author":"E Foggin","year":"2017","journal-title":"Br J Hosp Med (Lond)"},{"issue":"12","key":"pone.0244765.ref003","doi-asserted-by":"crossref","first-page":"516","DOI":"10.47102\/annals-acadmedsg.V47N12p516","article-title":"Psychological Profile of Patients with Psoriasis","volume":"47","author":"DS Lim","year":"2018","journal-title":"Ann Acad Med Singapore"},{"issue":"8","key":"pone.0244765.ref004","doi-asserted-by":"crossref","first-page":"e0182145","DOI":"10.1371\/journal.pone.0182145","article-title":"Social isolation, loneliness and their relationships with depressive symptoms: A population-based study","volume":"12","author":"L Ge","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"pone.0244765.ref005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/jid.2013.446","article-title":"The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions","volume":"134","author":"RJ Hay","year":"2014","journal-title":"J Invest Dermatol"},{"key":"pone.0244765.ref006","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/geront\/46.4.503","article-title":"Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations","volume":"46","author":"J Lubben","year":"2006","journal-title":"The Gerontologist"},{"key":"pone.0244765.ref007","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0164027504268574","article-title":"A short scale for measuring loneliness in large surveys","volume":"26","author":"ME Hughes","year":"2004","journal-title":"Res Aging"},{"issue":"10","key":"pone.0244765.ref008","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"M Herdman","year":"2011","journal-title":"Qual Life Res"},{"issue":"6","key":"pone.0244765.ref009","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11136-014-0859-5","article-title":"Population norms for the EQ-5D index scores using Singapore preference weights","volume":"24","author":"E Abdin","year":"2015","journal-title":"Qual Life Res"},{"issue":"4","key":"pone.0244765.ref010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3390\/jcm4040535","article-title":"Sick Leave and Factors Influencing Sick Leave in Adult Patients with Atopic Dermatitis: A Cross-Sectional Study","volume":"4","author":"H van Os-Medendorp","year":"2015","journal-title":"J Clin Med"},{"key":"pone.0244765.ref011","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1186\/1471-2458-12-861","article-title":"Short-term sick leave and future risk of sickness absence and unemployment\u2014the impact of health status","volume":"12","author":"H Hultin","year":"2012","journal-title":"BMC Public Health"},{"issue":"7","key":"pone.0244765.ref012","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/jech-2014-205088","article-title":"Associations of financial strain and income with depressive and anxiety disorders","volume":"69","author":"SM Dijkstra-Kersten","year":"2015","journal-title":"J Epidemiol Community Health"},{"key":"pone.0244765.ref013","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jad.2017.06.007","article-title":"The depression and marital status relationship is modified by both age and gender","volume":"223","author":"AGM Bulloch","year":"2017","journal-title":"J Affect Disord"},{"issue":"5","key":"pone.0244765.ref014","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.anai.2018.07.019","article-title":"Atopic dermatitis in US adults: Epidemiology, association with marital status, and atopy","volume":"121","author":"T Hua","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"pone.0244765.ref015","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/bjd.15497","article-title":"High prevalence of alcohol use disorders in patients with inflammatory skin diseases","volume":"177","author":"K Al-Jefri","year":"2017","journal-title":"Br J Dermatol"},{"issue":"5","key":"pone.0244765.ref016","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","article-title":"Alcohol and depression","volume":"106","author":"JM Boden","year":"2011","journal-title":"Addiction"},{"issue":"14","key":"pone.0244765.ref017","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1001\/archinte.160.14.2101","article-title":"Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence","volume":"160","author":"MR DiMatteo","year":"2000","journal-title":"Arch Intern Med"},{"issue":"5","key":"pone.0244765.ref018","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000447267","article-title":"Tailored Therapist-Guided Internet-Based Cognitive Behavioral Treatment for Psoriasis: A Randomized Controlled Trial","volume":"85","author":"S van Beugen","year":"2016","journal-title":"Psychother Psychosom"},{"key":"pone.0244765.ref019","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12671-018-0973-5","article-title":"Mindfulness-Based Interventions for Psoriasis: a Randomized Controlled Trial.","volume":"10","author":"P D\u2019Alton","year":"2019","journal-title":"Mindfulness"},{"issue":"3","key":"pone.0244765.ref020","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jaci.2017.01.029","article-title":"Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial","volume":"140","author":"A Heratizadeh","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"pone.0244765.ref021","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1186\/s12889-019-7775-0","article-title":"The psychosocial adaptation of patients with skin disease: a scoping review","volume":"19","author":"XJ Zhang","year":"2019","journal-title":"BMC Public Health"},{"issue":"12","key":"pone.0244765.ref022","first-page":"789","article-title":"A review of patients managed at a combined psychodermatology clinic: a Singapore experience","volume":"53","author":"WL Chung","year":"2012","journal-title":"Singapore Med J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T05:14:20Z","timestamp":1670649260000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0244765"}},"subtitle":[],"editor":[{"given":"Feroze","family":"Kaliyadan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0244765","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}