{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:27:45Z","timestamp":1783085265306,"version":"3.54.6"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone <jats:italic>ab interno<\/jats:italic> trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation glaucoma (PEG; n = 18) with a 12-month follow-up period were included in the study. The decreases in IOP and medication score from the baseline to the all-time-point were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001). The surgical success rates were 97.1%, 76.5%, and 44.0% at 3 months (90 days), 6 months (180 days), and 12 months (365 days), respectively. A mixed effect Cox model revealed that the type of glaucoma (POAG) was significantly associated with surgical failure (<jats:italic>P<\/jats:italic> = 0.044). Furthermore, the surgical success rate was significantly higher in eyes with PEG than it was in those with POAG (<jats:italic>P<\/jats:italic> = 0.019). Stand-alone <jats:italic>ab interno<\/jats:italic> trabeculotomy significantly lowered both the IOP and the medication score in patients with glaucoma, although almost one quarter of the cases needed additional glaucoma surgeries. The surgical success rate was significantly higher in eyes with PEG than it was in those with POAG.<\/jats:p>","DOI":"10.1371\/journal.pone.0245015","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T21:45:35Z","timestamp":1610055935000},"page":"e0245015","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-6839","authenticated-orcid":true,"given":"Takashi","family":"Omoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-3264","authenticated-orcid":true,"given":"Takashi","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Asano-Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Honjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"pone.0245015.ref001","doi-asserted-by":"crossref","first-page":"xxv","DOI":"10.1016\/j.ajo.2018.04.009","article-title":"Is Newer Necessarily Better? The Evolution of Incisional Glaucoma Surgery Over the Last 100 Years","volume":"191","author":"EJ Higginbotham","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"pone.0245015.ref002","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/OPTH.S239772","article-title":"Prospective Studies of Minimally Invasive Glaucoma Surgeries: Systematic Review and Quality Assessment","volume":"14","author":"JA Rosdahl","year":"2020","journal-title":"Clin Ophthalmol"},{"issue":"Suppl 1","key":"pone.0245015.ref003","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1097\/IJG.0000000000000918","article-title":"Recent Advances in the Surgical Management of Glaucoma in Exfoliation Syndrome","volume":"27","author":"MS Sayed","year":"2018","journal-title":"J Glaucoma"},{"key":"pone.0245015.ref004","first-page":"189","article-title":"Minimally invasive glaucoma surgery: current status and future prospects","volume":"10","author":"GM Richter","year":"2016","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"pone.0245015.ref005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/ICU.0000000000000457","article-title":"Complications of micro-invasive glaucoma surgery","volume":"29","author":"E Yook","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"key":"pone.0245015.ref006","article-title":"Clinical practice preferences for glaucoma surgery in Japan: a survey of Japan Glaucoma Society specialists","author":"K Iwasaki","year":"2020","journal-title":"Jpn J Ophthalmol"},{"issue":"12","key":"pone.0245015.ref007","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/archopht.1993.01090120075025","article-title":"Surgical effects of trabeculotomy ab externo on adult eyes with primary open angle glaucoma and pseudoexfoliation syndrome","volume":"111","author":"H Tanihara","year":"1993","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"pone.0245015.ref008","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0886-3350(96)80017-4","article-title":"Trabeculotomy ab externo, cataract extraction, and intraocular lens implantation: Preliminary report","volume":"22","author":"M Honjo","year":"1996","journal-title":"Journal of Cataract & Refractive Surgery"},{"issue":"4","key":"pone.0245015.ref009","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00061198-200108000-00010","article-title":"Surgical outcome of combined trabeculotomy and cataract surgery","volume":"10","author":"M Tanito","year":"2001","journal-title":"J Glaucoma"},{"issue":"3","key":"pone.0245015.ref010","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajo.2012.09.023","article-title":"Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device","volume":"155","author":"LK Seibold","year":"2013","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"pone.0245015.ref011","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jcrs.2017.06.046","article-title":"Goniotomy with a single-use dual blade: Short-term results","volume":"43","author":"MD Greenwood","year":"2017","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"pone.0245015.ref012","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s12325-018-0755-4","article-title":"12-Month Outcomes of Goniotomy Performed Using the Kahook Dual Blade Combined with Cataract Surgery in Eyes with Medically Treated Glaucoma","volume":"35","author":"SK Dorairaj","year":"2018","journal-title":"Adv Ther"},{"key":"pone.0245015.ref013","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2147\/OPTH.S158403","article-title":"A multicenter retrospective comparison of goniotomy versus trabecular bypass device implantation in glaucoma patients undergoing cataract extraction","volume":"12","author":"SK Dorairaj","year":"2018","journal-title":"Clin Ophthalmol"},{"issue":"9","key":"pone.0245015.ref014","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1007\/s12325-019-01025-1","article-title":"12-Month Retrospective Comparison of Kahook Dual Blade Excisional Goniotomy with Istent Trabecular Bypass Device Implantation in Glaucomatous Eyes at the Time of Cataract Surgery","volume":"36","author":"MK ElMallah","year":"2019","journal-title":"Adv Ther"},{"key":"pone.0245015.ref015","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2147\/OPTH.S208468","article-title":"Comparison Of Surgical Outcomes Of 360 degrees Circumferential Trabeculotomy Versus Sectoral Excisional Goniotomy With The Kahook Dual Blade At 6 Months","volume":"13","author":"MT Hirabayashi","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"pone.0245015.ref016","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2147\/OPTH.S196105","article-title":"Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months","volume":"13","author":"MT Hirabayashi","year":"2019","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"pone.0245015.ref017","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10384-020-00750-3","article-title":"Comparison of the short-term effectiveness and safety profile of ab interno combined trabeculotomy using 2 types of trabecular hooks","volume":"64","author":"T Omoto","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0245015.ref018","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.2147\/OPTH.S224109","article-title":"Comparison Of Surgical Outcomes Between Excisional Goniotomy Using The Kahook Dual Blade And iStent Trabecular Micro-Bypass Stent In Combination With Phacoemulsification","volume":"13","author":"D Lee","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"pone.0245015.ref019","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2147\/OPTH.S224643","article-title":"Early Results of Goniotomy with the Kahook Dual Blade, a Novel Device for the Treatment of Glaucoma","volume":"13","author":"HL Kornmann","year":"2019","journal-title":"Clin Ophthalmol"},{"issue":"11","key":"pone.0245015.ref020","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s12325-018-0803-0","article-title":"Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure","volume":"35","author":"JP Berdahl","year":"2018","journal-title":"Adv Ther"},{"issue":"8","key":"pone.0245015.ref021","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/IJG.0000000000000701","article-title":"Ab Interno Trabeculectomy With a Dual Blade: Surgical Technique for Childhood Glaucoma","volume":"26","author":"AS Khouri","year":"2017","journal-title":"J Glaucoma"},{"key":"pone.0245015.ref022","first-page":"1120672119892440","article-title":"Ab interno trabeculectomy with the dual blade in juvenile open-angle glaucoma","author":"AS Khouri","year":"2019","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"pone.0245015.ref023","doi-asserted-by":"crossref","first-page":"NP16","DOI":"10.1177\/1120672118805873","article-title":"Use of ab interno Kahook Dual Blade trabeculectomy for treatment of primary congenital glaucoma","volume":"30","author":"MM Harvey","year":"2020","journal-title":"Eur J Ophthalmol"},{"issue":"7","key":"pone.0245015.ref024","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.ophtha.2015.03.021","article-title":"The Effect of Phacoemulsification on Intraocular Pressure in Glaucoma Patients: A Report by the American Academy of Ophthalmology","volume":"122","author":"PP Chen","year":"2015","journal-title":"Ophthalmology"},{"issue":"11","key":"pone.0245015.ref025","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0886-3350(01)01036-7","article-title":"Effect of cataract surgery on intraocular pressure control in glaucoma patients","volume":"27","author":"K Hayashi","year":"2001","journal-title":"Journal of Cataract & Refractive Surgery"},{"issue":"8","key":"pone.0245015.ref026","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jcrs.2014.06.001","article-title":"Lens-based glaucoma surgery: using cataract surgery to reduce intraocular pressure","volume":"40","author":"RH Brown","year":"2014","journal-title":"J Cataract Refract Surg"},{"issue":"5","key":"pone.0245015.ref027","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.survophthal.2017.08.006","article-title":"The role of phacoemulsification in glaucoma therapy: A systematic review and meta-analysis","volume":"63","author":"M Masis","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"pone.0245015.ref028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2018.01.003","article-title":"Cataract, phacoemulsification and intraocular pressure: Is the anterior segment anatomy the missing piece of the puzzle?","volume":"64","author":"M Masis Solano","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"pone.0245015.ref029","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/IJG.0000000000000643","article-title":"The Effects of Phacoemulsification on Intraocular Pressure and Topical Medication Use in Patients With Glaucoma: A Systematic Review and Meta-analysis of 3-Year Data","volume":"26","author":"JJ Armstrong","year":"2017","journal-title":"J Glaucoma"},{"issue":"2","key":"pone.0245015.ref030","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/ICU.0b013e3283360ac3","article-title":"The effect of cataract extraction on intraocular pressure","volume":"21","author":"A Shrivastava","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"issue":"4","key":"pone.0245015.ref031","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jml.2007.12.005","article-title":"Mixed-effects modeling with crossed random effects for subjects and items","volume":"59","author":"RH Baayen","year":"2008","journal-title":"Journal of Memory and Language"},{"issue":"1","key":"pone.0245015.ref032","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Usinglme4","volume":"67","author":"D Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"key":"pone.0245015.ref033","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","article-title":"A multiple comparison procedure for comparing several treatments with a control","volume":"50","author":"CW Dunnett","year":"1955","journal-title":"Am Stat Assoc"},{"issue":"5","key":"pone.0245015.ref034","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ajo.2011.10.026","article-title":"Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up","volume":"153","author":"SJ Gedde","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"pone.0245015.ref035","unstructured":"Therneau T. Mixed effects Cox models. CRAN repository. 2015."},{"issue":"1","key":"pone.0245015.ref036","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ophtha.2019.04.034","article-title":"A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatment of Open-Angle Glaucoma: The COMPARE Study","volume":"127","author":"IIK Ahmed","year":"2020","journal-title":"Ophthalmology"},{"key":"pone.0245015.ref037","article-title":"Comparison of 12-month surgical outcomes of ab interno trabeculotomy with phacoemulsification between spatula-shaped and dual-blade microhooks","author":"T Omoto","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0245015.ref038","first-page":"1120672119848277","article-title":"Efficacy and safety of the ab interno gelatin stent in severe pseudoexfoliation glaucoma compared to non-pseudoexfoliation glaucoma at 6 months","author":"N Dar","year":"2019","journal-title":"Eur J Ophthalmol"},{"issue":"5","key":"pone.0245015.ref039","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jcrs.2017.02.029","article-title":"Trabecular microbypass stent implantation with cataract extraction in pseudoexfoliation glaucoma","volume":"43","author":"TJ Ferguson","year":"2017","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"pone.0245015.ref040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0161-6420(88)33190-8","article-title":"The Presentation and Prognosis of Glaucoma in Pseudoexfoliation of the Lens Capsule","volume":"95","author":"AMV Brooks","year":"1988","journal-title":"Ophthalmology"},{"issue":"10","key":"pone.0245015.ref041","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/archopht.117.10.1319","article-title":"The relationship between glaucoma and pseudoexfoliation: the Blue Mountains Eye Study","volume":"117","author":"P Mitchell","year":"1999","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"pone.0245015.ref042","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00061198-199400320-00018","article-title":"Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma","volume":"3","author":"R Ritch","year":"1994","journal-title":"J Glaucoma"},{"issue":"3","key":"pone.0245015.ref043","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1350-9462(99)00019-1","article-title":"Exfoliation syndrome and exfoliation glaucoma","volume":"19","author":"E Vesti","year":"2000","journal-title":"Progress in Retinal and Eye Research"},{"key":"pone.0245015.ref044","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2147\/OPTH.S181444","article-title":"Monitoring and management of the patient with pseudoexfoliation syndrome: current perspectives","volume":"13","author":"K Tekin","year":"2019","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"pone.0245015.ref045","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ajo.2009.03.024","article-title":"Increased likelihood of glaucoma at the same screening intraocular pressure in subjects with pseudoexfoliation: the Thessaloniki Eye Study","volume":"148","author":"F Topouzis","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"pone.0245015.ref046","first-page":"970","article-title":"Increased extracellular deposition of fibrillin-containing fibrils in pseudoexfoliation syndrome","volume":"38","author":"U Schlotzer-Schrehardt","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0245015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T21:46:48Z","timestamp":1610056008000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0245015"}},"subtitle":[],"editor":[{"given":"Ahmed","family":"Awadein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0245015","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]}}}