{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:13:47Z","timestamp":1747196027999,"version":"3.40.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>The effect of statins on wound healing is controversial, and their effect on trabeculectomy outcomes remains unclear. This study aimed to examine the relationship between oral statin use and trabeculectomy outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Medical records of patients who underwent primary mitomycin-C augmented trabeculectomy with 2 years of follow-up were reviewed. Pre- and postoperative intraocular pressures (IOP) and numbers of medications, subconjunctival 5-fluorouracil (5-FU) injections, and bleb-needling procedures were compared between statin users and nonusers. Failure was defined as an eye that failed to achieve a 20% lowering of IOP from baseline or had an IOP &gt; 21 mm Hg, as well as an eye that required further surgical intervention, developed hypotony, or had no light perception visual acuity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In total, 158 subjects were enrolled, with 47 eyes from statin users and 111 eyes from statin nonusers. The 24-month cumulative probability of failure was 78.7% for statin users and 60.4% for nonusers (<jats:italic>P<\/jats:italic> = .013). Cox proportional-hazards modeling showed a significantly higher hazard risk in statin users (adjusted hazard ratio 1.61, <jats:italic>P<\/jats:italic> = .026). There were no significant between-group differences in mean IOPs or number of medications (both <jats:italic>P<\/jats:italic> &gt; .05) at 24 months. Multivariable Poisson regression analysis that statin use was associated with increased numbers of 5-FU injections (<jats:italic>P<\/jats:italic> = .014) and bleb-needling procedures (<jats:italic>P<\/jats:italic> = .031).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study demonstrated that oral statin use was associated with higher rates of trabeculectomy failure and increased numbers of 5-FU injections and bleb-needling procedures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0245429","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:29:47Z","timestamp":1610735387000},"page":"e0245429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of oral statin use on mitomycin-C augmented trabeculectomy outcomes"],"prefix":"10.1371","volume":"16","author":[{"given":"Abhibol","family":"Inobhas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-2868","authenticated-orcid":true,"given":"Sunee","family":"Chansangpetch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Manassakorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visanee","family":"Tantisevi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prin","family":"Rojanapongpun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"issue":"10","key":"pone.0245429.ref001","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"A Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"pone.0245429.ref002","doi-asserted-by":"crossref","first-page":"6509809","DOI":"10.1155\/2016\/6509809","article-title":"Medical Management of Glaucoma in the 21st Century from a Canadian Perspective","volume":"2016","author":"P Harasymowycz","year":"2016","journal-title":"J Ophthalmol"},{"issue":"8","key":"pone.0245429.ref003","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0161-6420(97)30155-9","article-title":"Needling versus medical treatment in encapsulated blebs. 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