{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:47:48Z","timestamp":1770778068706,"version":"3.50.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research program of the Japan Society for the Promotion of Science","award":["16K08636, 19K11785"],"award-info":[{"award-number":["16K08636, 19K11785"]}]},{"name":"Grant-in-Aid for Scientific Research program of the Japan Society for the Promotion of Science","award":["17H03808"],"award-info":[{"award-number":["17H03808"]}]},{"DOI":"10.13039\/100009578","name":"Mizutani Foundation for Glycoscience","doi-asserted-by":"publisher","award":["200049"],"award-info":[{"award-number":["200049"]}],"id":[{"id":"10.13039\/100009578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["30-14"],"award-info":[{"award-number":["30-14"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Mucins, the major components of salivary mucus, are large glycoproteins abundantly modified with O-glycans. Mucins present on the surface of oral tissues contribute greatly to the maintenance of oral hygiene by selectively adhering to the surfaces of microbes via mucin O-glycans. However, due to the complex physicochemical properties of mucins, there have been relatively few detailed analyses of the mechanisms controlling the expression of mucin genes and the glycosyltransferase genes involved in glycosylation. Analysis performed using supported molecular matrix electrophoresis, a methodology developed for mucin analysis, and knockout mice without the polycomb group protein Bmi-1 revealed that Bmi-1 regulates mucin levels in the submandibular gland by suppressing the expression of the mucin <jats:italic>Smgc<\/jats:italic> gene, and that Bmi-1 also regulates mucin O-glycosylation via suppression of the glycosyltransferase <jats:italic>Gcnt3<\/jats:italic> gene in the submandibular gland.<\/jats:p>","DOI":"10.1371\/journal.pone.0245607","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T18:35:51Z","timestamp":1611081351000},"page":"e0245607","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of 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