{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:38:32Z","timestamp":1774877912994,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Healthcare Research Project","award":["SZGW2018001"],"award-info":[{"award-number":["SZGW2018001"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Syphilis is a common infectious disease worldwide. Serological monitoring is important for syphilis management. We currently know little about the characteristics of this seronegative response. The aim of this study was to explore the factors associated with serological cure after treatment of early syphilis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective cohort study was conducted and the data of patients with early syphilis in a clinic in Shenzhen from 2011 to 2019 were retrieved. Univariable and multiple Cox proportional hazard regression models were utilized to identify factors associated with a serological cure state among syphilis patients with early syphilis two years after treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 346 (85.9%) syphilis patients achieved serological cure. The multivariate analysis results revealed that having a baseline TRUST titer &gt;1:8 was associated with an increased probability of serological cure, compared with having a baseline TRUST titer \u22641:8 (HR = 1.43, 95% CI = 1.10\u20131.85, P&lt;0.01); primary syphilis was positively associated with serological cure, compared with participants with latent early syphilis (HR = 1.72, 95% CI = 1.27\u20132.33, P&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Two years after treatment, a higher percentage of early syphilis patients achieved serological cure. The study indicated that the syphilis stage and baseline serum titer were crucial factors associated with serological cure.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0245812","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T19:04:19Z","timestamp":1611860659000},"page":"e0245812","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China"],"prefix":"10.1371","volume":"16","author":[{"given":"Zhenzhou","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-8305","authenticated-orcid":true,"given":"Jinsong","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"issue":"10078","key":"pone.0245812.ref001","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(16)32411-4","article-title":"Syphilis","volume":"389","author":"EW 3rd Hook","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"pone.0245812.ref002","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/sti.2005.015875","article-title":"Syphilis in adults","volume":"81","author":"BT Goh","year":"2005","journal-title":"Sex Transm Infect"},{"key":"pone.0245812.ref003","volume-title":"Report on global sexually transmitted infection surveillance 2015","author":"WHO","year":"2016"},{"key":"pone.0245812.ref004","volume-title":"Report on global sexually transmitted infection surveillance 2018","author":"WHO","year":"2018"},{"issue":"7","key":"pone.0245812.ref005","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1473-3099(17)30227-X","article-title":"Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study","volume":"17","author":"S Yang","year":"2017","journal-title":"The Lancet Infectious Diseases"},{"key":"pone.0245812.ref006","unstructured":"Chen XS. 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