{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:50:30Z","timestamp":1791946230125,"version":"4.3.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Emerging infectious diseases such as Ebola Virus Disease (EVD), Nipah Virus Encephalitis and Lassa fever pose significant epidemic threats. Responses to emerging infectious disease outbreaks frequently occur in resource-constrained regions and under high pressure to quickly contain the outbreak prior to potential spread. As seen in the 2020 EVD outbreaks in the Democratic Republic of Congo and the current COVID-19 pandemic, there is a continued need to evaluate and address the ethical challenges that arise in the high stakes environment of an emerging infectious disease outbreak response. The research presented here provides analysis of the ethical challenges with regard to allocation of limited resources, particularly experimental therapeutics, using the 2013\u20132016 EVD outbreak in West Africa as a case study. In-depth semi-structured interviews were conducted with senior healthcare personnel (n = 16) from international humanitarian aid organizations intimately engaged in the 2013\u20132016 EVD outbreak response in West Africa. Interviews were recorded in private setting, transcribed, and iteratively coded using grounded theory methodology. A majority of respondents indicated a clear propensity to adopt an ethical framework of guiding principles for international responses to emerging infectious disease outbreaks. Respondents agreed that prioritization of frontline workers\u2019 access to experimental therapeutics was warranted based on a principle of reciprocity. There was widespread acceptance of adaptive trial designs and greater trial transparency in providing access to experimental therapeutics. Many respondents also emphasized the importance of community engagement in limited resource allocation scheme design and culturally appropriate informed consent procedures. The study results inform a potential ethical framework of guiding principles based on the interview participants\u2019 insights to be adopted by international response organizations and their healthcare workers in the face of allocating limited resources such as experimental therapeutics in future emerging infectious disease outbreaks to ease the moral burden of individual healthcare providers.<\/jats:p>","DOI":"10.1371\/journal.pone.0246320","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T14:21:22Z","timestamp":1612275682000},"page":"e0246320","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ethics of emerging infectious disease outbreak responses: Using Ebola virus disease as a case study of limited resource allocation"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-9671","authenticated-orcid":true,"given":"Ariadne 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Being Shot During Clash Over Ebola Quarantine\u2014The New York Times","author":"N Onishi","year":"2014","journal-title":"The New York Times"},{"key":"pone.0246320.ref004","author":"World Health Organization","year":"2016","journal-title":"Situation Report Ebola Virus Disease"},{"key":"pone.0246320.ref005","first-page":"63","author":"DG Bausch","year":"2017","journal-title":"West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis"},{"key":"pone.0246320.ref006","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11673-014-9580-x","article-title":"Ebola Virus in West Africa: Waiting for the Owl of Minerva","volume":"11","author":"REG Upshur","year":"2014","journal-title":"J Bioeth Inq"},{"key":"pone.0246320.ref007","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2105\/AJPH.2015.302757","article-title":"Evolving Challenges and Research-Needs Concerning Ebola","volume":"105","author":"R Klitzman","year":"2015","journal-title":"Am J Public 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Miles","year":"2014","edition":"3"},{"key":"pone.0246320.ref012","volume-title":"Qualitative Research Methods for Community Development.","author":"RM Silverman","year":"2015"},{"key":"pone.0246320.ref013","volume-title":"Learning from strangers: The art and method of qualitative interview studies","author":"RS Weiss","year":"1994"},{"key":"pone.0246320.ref014","volume-title":"Qualitative research and evaluation methods.","author":"MQ Patton","year":"2002","edition":"3"},{"key":"pone.0246320.ref015","volume-title":"Qualitative Research Design: An Interactive Approach","author":"JA Maxwell","year":"2013"},{"key":"pone.0246320.ref016","volume-title":"Principles of biomedical ethics","author":"TL Beauchamp","year":"2009"},{"key":"pone.0246320.ref017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.1001793","article-title":"Humanitarian Access to Unapproved Interventions in Public Health Emergencies of International Concern","volume":"12","author":"JA Singh","year":"2015","journal-title":"PLoS Med"},{"key":"pone.0246320.ref018","author":"FDA US","year":"2016","journal-title":"Expanded Access to Investigational Drugs for Treatment Use\u2014Questions and Answers Guidance for Industry"},{"key":"pone.0246320.ref019","author":"World Health Organization","year":"2014","journal-title":"Ethical considerations for use of unregistered interventions for Ebola viral disease: report of an advisory panel to WHO"},{"key":"pone.0246320.ref020","unstructured":"WHO Ethics Working Group. Ethical issues related to study design for trials on therapeutics for Ebola Virus Disease: WHO Ethics Working Group Meeting 20\u201321 October, Summary of Discussion. 2014. Available: www.who.int\/about\/licensing\/copyright_form\/en\/index.html"},{"key":"pone.0246320.ref021","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12978-017-0429-8","article-title":"Nubia\u2019s mother: being pregnant in the time of experimental vaccines and therapeutics for Ebola","volume":"14","author":"S Caluwaerts","year":"2017","journal-title":"Reprod Health"},{"key":"pone.0246320.ref022","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1056\/NEJMc1415318","article-title":"Ebola Virus Disease among Children in West Africa","volume":"372","author":"J Agua-Agum","year":"2015","journal-title":"N Engl J Med"},{"key":"pone.0246320.ref023","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/S2214-109X(15)00065-0","article-title":"Health-care worker mortality and the legacy of the Ebola epidemic","volume":"3","author":"DK Evans","year":"2015","journal-title":"Lancet Glob Heal"},{"key":"pone.0246320.ref024","doi-asserted-by":"crossref","first-page":"e0168975","DOI":"10.1371\/journal.pone.0168975","article-title":"A Systematic Review of Ebola Treatment Trials to Assess the Extent to Which They Adhere to Ethical Guidelines","volume":"12","author":"T Richardson","year":"2017","journal-title":"PLoS One"},{"key":"pone.0246320.ref025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/medethics-2016-103474","article-title":"The Ebola clinical trials: a precedent for research ethics in disasters","volume":"44","author":"P Calain","year":"2018","journal-title":"J Med Ethics"},{"key":"pone.0246320.ref026","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12910-016-0135-z","article-title":"Ethical considerations surrounding the response to Ebola: the Spanish experience","volume":"17","author":"M\u00c1 Royo-Bordonada","year":"2016","journal-title":"BMC Med Ethics"},{"key":"pone.0246320.ref027","first-page":"1","article-title":"Rethinking resistance: public health professionals on empathy and ethics in the 2014\u20132015 Ebola response in Sierra Leone and Liberia","author":"A Walker","year":"2019","journal-title":"Crit Public Health"},{"key":"pone.0246320.ref028","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12913-018-3072-3","article-title":"Health workers\u2019 experiences of coping with the Ebola epidemic in Sierra Leone\u2019s health system: a qualitative study","volume":"18","author":"J Raven","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"pone.0246320.ref029","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1136\/medethics-2014-102561","article-title":"Ethical challenges of containing Ebola: the Nigerian experience","volume":"41","author":"O Maduka","year":"2015","journal-title":"J Med Ethics"},{"key":"pone.0246320.ref030","unstructured":"WHO. Guidance for Managing Ethical Issues in Infectious Disease Outbreaks. Geneva; 2016. Available: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/250580\/9789241549837-eng.pdf?sequence=1"},{"key":"pone.0246320.ref031","doi-asserted-by":"crossref","DOI":"10.17226\/24739","volume-title":"Integrating Clinical Research into Epidemic Response","author":"G Keusch","year":"2017"},{"key":"pone.0246320.ref032","unstructured":"WHO. Blueprint for R&D preparedness and response to public health emergencies due to highly infectious pathogens: WORKSHOP ON PRIORITIZATION OF PATHOGENS. 2015. Available: https:\/\/www.who.int\/blueprint\/what\/research-development\/meeting-report-prioritization.pdf?ua=1"},{"key":"pone.0246320.ref033","unstructured":"WHO. A research and development Blueprint for action to prevent epidemics. 2018. Available: https:\/\/www.who.int\/blueprint\/en\/"},{"key":"pone.0246320.ref034","unstructured":"WHO. Ebola virus disease\u2013Democratic Republic of the Congo. 2020 [cited 20 Jan 2021]. Available: https:\/\/www.who.int\/csr\/don\/03-June-2020-ebola-drc\/en\/"},{"key":"pone.0246320.ref035","article-title":"Key Ethical Concepts and Their Application to COVID-19 Research","author":"A Dawson","year":"2020","journal-title":"Public Health Ethics"},{"key":"pone.0246320.ref036","doi-asserted-by":"crossref","first-page":"e0230683","DOI":"10.1371\/journal.pone.0230683","article-title":"Challenges to Ebola preparedness during an ongoing outbreak: An analysis of borderland livelihoods and trust in Uganda.","volume":"15","author":"MM Schmidt-Sane","year":"2020","journal-title":"PLoS One"},{"key":"pone.0246320.ref037","doi-asserted-by":"crossref","first-page":"e0223104","DOI":"10.1371\/journal.pone.0223104","article-title":"Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study.","volume":"14","author":"K Masumbuko Claude","year":"2019","journal-title":"PLoS One"},{"key":"pone.0246320.ref038","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/15265161.2020.1795539","article-title":"Allocating Scarce Unproven Interventions during Public Health Emergencies: Insights from the WHO MEURI Framework","volume":"20","author":"I Mastroleo","year":"2020","journal-title":"Am J Bioeth"},{"key":"pone.0246320.ref039","article-title":"A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics","author":"S Mulangu","year":"2019","journal-title":"N Engl J Med"},{"key":"pone.0246320.ref040","unstructured":"WHO. 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