{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:49:02Z","timestamp":1784918942485,"version":"3.55.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["7-11-0213"],"award-info":[{"award-number":["7-11-0213"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["117548"],"award-info":[{"award-number":["117548"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R155-2013-14070"],"award-info":[{"award-number":["R155-2013-14070"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Multiple chemical sensitivity (MCS) is characterized by widespread symptoms attributed to exposure to airborne chemicals. MCS is categorized as a functional somatic syndrome (FSS), and MCS cases often meet the criteria for other types of FSS, e.g. fibromyalgia. The primary aim was to characterize MCS regarding symptom triggers, symptoms, lifestyle and describe demographics, socioeconomics and lifestyle factors associated with MCS. A secondary aim was to examine the implication of FSS comorbidity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data were derived from a random sample of the Danish adult population enrolled in the Danish Study of Functional Disorders (DanFunD; n = 9,656). Questionnaire data comprised information used to delimit MCS and four additional types of FSS, as well as data on demographics, socioeconomics and lifestyle. MCS cases (n = 188) was stratified into subgroups; MCS only (n = 109) and MCS with comorbid FSS (n = 73). Information regarding FSS comorbidities were missing for six MCS cases. MCS subgroups and controls without FSS comorbidities (n = 7,791) were compared by means of logistic regression analyses, adjusted for age and sex.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>MCS was associated with female sex, not being in occupation and low social status, but not with age or education. MCS cases reported normal dietary intake and smoking habits and lower alcohol consumption. Additional associations were found between MCS and low rate of cohabitation, sedentarism, daily physically limitations, and poor quality of sleep. However, subgroup analysis revealed that these findings were primarily associated with MCS with comorbid FSS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>MCS was associated with lower socioeconomic status, physically inactivity and poor quality of sleep. Subgroup analysis revealed that several associations was explained by FSS comorbidity, i.e. MCS cases with no comorbid FSS showed normal rate of cohabitation and did not report physical limitations or difficulties sleeping. Overall, our findings emphasise the importance of screening MCS cases for FSS comorbidity both in epidemiological and clinical settings.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0246461","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T18:33:10Z","timestamp":1614191590000},"page":"e0246461","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Multiple chemical sensitivity described in the Danish general population: Cohort characteristics and the importance of screening for functional somatic syndrome comorbidity\u2014The DanFunD study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-7052","authenticated-orcid":true,"given":"Thomas Meinertz","family":"Dantoft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Weinreich","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sine","family":"Skovbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"issue":"3\u20134","key":"pone.0246461.ref001","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/074823379901500311","article-title":"The Environmental Exposure and Sensitivity Inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications","volume":"15","author":"CS Miller","year":"1999","journal-title":"Toxicol Ind Health"},{"issue":"7","key":"pone.0246461.ref002","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00420-007-0282-0","article-title":"Prevalence of self-reported symptoms and consequences related to inhalation of airborne chemicals in a Danish general population","volume":"81","author":"ND Berg","year":"2008","journal-title":"Int Arch Occup Environ Health"},{"issue":"4","key":"pone.0246461.ref003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00420-008-0352-y","article-title":"Phenotypes of individuals affected by airborne chemicals in the general population","volume":"82","author":"ND Berg","year":"2009","journal-title":"Int Arch Occup Environ Health"},{"issue":"4","key":"pone.0246461.ref004","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijheh.2005.03.006","article-title":"Self-reported chemical sensitivity in Germany: a population-based survey","volume":"208","author":"C Hausteiner","year":"2005","journal-title":"Int J Hyg Environ Health"},{"issue":"2","key":"pone.0246461.ref005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/157339711102150702111101","article-title":"Chemical intolerance","volume":"11","author":"TM Dantoft","year":"2015","journal-title":"Curr Rheumatol Rev"},{"issue":"3","key":"pone.0246461.ref006","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1097\/JOM.0000000000001272","article-title":"National Prevalence and Effects of Multiple Chemical Sensitivities","volume":"60","author":"A Steinemann","year":"2018","journal-title":"J Occup Environ Med"},{"key":"pone.0246461.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb05810.x","article-title":"The compelling anomaly of chemical intolerance","volume":"933","author":"CS Miller","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"pone.0246461.ref008","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0091-6749(94)70041-9","article-title":"Multiple chemical sensitivity or multi-organ dysesthesia","volume":"93","author":"JR Cohn","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"pone.0246461.ref009","unstructured":"NICNAS, OCSEH. Multiple Chemical Sensitivity: Identifying Key Research Needs; National Industrial Chemicals Notification and Assessment Scheme, Australia; Office of Chemical Safety and Environmental Health, Australia. 2010 2010. Report No.: 1."},{"issue":"4","key":"pone.0246461.ref010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/096032719701600414","article-title":"Report of Multiple Chemical Sensitivities (MCS) Workshop, Berlin, Germany, 21\u201323 February 1996. 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Research design II: cohort, cross sectional, and case-control studies","volume":"20","author":"CJ Mann","year":"2003","journal-title":"Emerg Med J"},{"key":"pone.0246461.ref032","volume-title":"Epidemiology for the uninitiated","author":"DD Coggon","year":"2003","edition":"5"},{"issue":"6","key":"pone.0246461.ref033","first-page":"413","article-title":"Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity","volume":"64","author":"H Hu","year":"2018","journal-title":"Can Fam Physician"},{"issue":"4","key":"pone.0246461.ref034","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/MOO.0b013e328259c360","article-title":"Multiple chemical sensitivities: review","volume":"15","author":"J Das-Munshi","year":"2007","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"pone.0246461.ref035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/CLEP.S129335","article-title":"Cohort description: The Danish study of Functional Disorders","volume":"Volume 9","author":"TM Dantoft","year":"2017","journal-title":"Clinical Epidemiology"},{"issue":"1","key":"pone.0246461.ref036","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1038\/s41598-020-60318-6","article-title":"Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD","volume":"10","author":"MW Petersen","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0246461.ref037","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/00039899909602251","article-title":"Multiple chemical sensitivity: a 1999 consensus","volume":"54","year":"1999","journal-title":"Arch Environ Health"},{"issue":"4","key":"pone.0246461.ref038","first-page":"880","article-title":"Testing an instrument to screen for fibromyalgia syndrome in general population studies: the London Fibromyalgia Epidemiology Study Screening Questionnaire","volume":"26","author":"KP White","year":"1999","journal-title":"J Rheumatol"},{"issue":"1","key":"pone.0246461.ref039","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychores.2009.10.007","article-title":"Measuring fatigue in clinical and community settings","volume":"69","author":"M Cella","year":"2010","journal-title":"J Psychosom Res"},{"issue":"2","key":"pone.0246461.ref040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0022-3999(93)90081-P","article-title":"Development of a fatigue scale","volume":"37","author":"T Chalder","year":"1993","journal-title":"J Psychosom Res"},{"issue":"5","key":"pone.0246461.ref041","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/00365529609006767","article-title":"Redefining abdominal syndromes. Results of a population-based study","volume":"31","author":"L Kay","year":"1996","journal-title":"Scand J Gastroenterol"},{"issue":"11","key":"pone.0246461.ref042","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1468-1331.2008.02301.x","article-title":"Clinical assessment of prognostic factors for long-term pain and handicap after whiplash injury: a 1-year prospective study","volume":"15","author":"H Kasch","year":"2008","journal-title":"Eur J Neurol"},{"issue":"6","key":"pone.0246461.ref043","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0277-9536(02)00131-4","article-title":"Subjective social status: its determinants and its association with measures of ill-health in the Whitehall II study","volume":"56","author":"A Singh-Manoux","year":"2003","journal-title":"Soc Sci Med"},{"issue":"2","key":"pone.0246461.ref044","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj.ejcn.1602503","article-title":"The Dietary Quality Score: validation and association with cardiovascular risk factors: the Inter99 study","volume":"61","author":"U Toft","year":"2007","journal-title":"Eur J Clin Nutr"},{"issue":"6","key":"pone.0246461.ref045","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/01.CIR.38.6.1104","article-title":"Physiological analysis of middle-aged and old former athletes. Comparison with still active athletes of the same ages","volume":"38","author":"B Saltin","year":"1968","journal-title":"Circulation"},{"issue":"4\u20135","key":"pone.0246461.ref046","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ijheh.2013.08.005","article-title":"Overlap in prevalence between various types of environmental intolerance","volume":"217","author":"E Palmquist","year":"2014","journal-title":"Int J Hyg Environ Health"},{"issue":"4","key":"pone.0246461.ref047","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/00039896.1996.9936026","article-title":"Prevalence and nature of allergy and chemical sensitivity in a general population","volume":"51","author":"WJ Meggs","year":"1996","journal-title":"Arch Environ Health"},{"issue":"7","key":"pone.0246461.ref048","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00420-005-0616-8","article-title":"Prevalence and risk factors for self-reported odour intolerance: the Skovde population-based study","volume":"78","author":"A Johansson","year":"2005","journal-title":"Int Arch Occup Environ Health"},{"key":"pone.0246461.ref049","volume":"2003","author":"M Eyeson-Annan","year":"2003","journal-title":"The New South Wales Adult Health Survey 2002"},{"issue":"3","key":"pone.0246461.ref050","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijheh.2018.02.009","article-title":"Physical and chemical trigger factors in environmental intolerance","volume":"221","author":"AS Claeson","year":"2018","journal-title":"Int J Hyg Environ Health"},{"issue":"7","key":"pone.0246461.ref051","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/JOM.0b013e3181a7f021","article-title":"The idiopathic environmental intolerance symptom inventory: development, evaluation, and application","volume":"51","author":"MJ Andersson","year":"2009","journal-title":"J Occup Environ Med"},{"issue":"8","key":"pone.0246461.ref052","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/07399332.2011.585727","article-title":"The experience of living with sensory hyperreactivity-accessibility, financial security, and social relationships","volume":"32","author":"A Soderholm","year":"2011","journal-title":"Health Care Women Int"},{"key":"pone.0246461.ref053","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.envres.2017.11.014","article-title":"Prevalence of various environmental intolerances in a Swedish and Finnish general population","volume":"161","author":"K Karvala","year":"2018","journal-title":"Environ Res"},{"issue":"6","key":"pone.0246461.ref054","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/occmed\/kqh083","article-title":"Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures","volume":"54","author":"CJ Baines","year":"2004","journal-title":"Occup Med (Lond)"},{"key":"pone.0246461.ref055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.psyneuen.2013.11.012","article-title":"An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity","volume":"40","author":"TM Dantoft","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"pone.0246461.ref056","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3200\/AEOH.58.6.300-305","article-title":"A national population study of the prevalence of multiple chemical sensitivity","volume":"59","author":"SM Caress","year":"2004","journal-title":"Arch Environ Health"},{"issue":"5","key":"pone.0246461.ref057","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/ije\/dyh251","article-title":"Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR","volume":"33","author":"G McKeown-Eyssen","year":"2004","journal-title":"Int J Epidemiol"},{"issue":"3","key":"pone.0246461.ref058","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/PSY.0000000000000405","article-title":"Long-Term Outcome of Bodily Distress Syndrome in Primary Care: A Follow-Up Study on Health Care Costs, Work Disability, and Self-Rated Health","volume":"79","author":"MT Rask","year":"2017","journal-title":"Psychosom Med"},{"issue":"5","key":"pone.0246461.ref059","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00006842-200009000-00009","article-title":"Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms","volume":"62","author":"LA Jason","year":"2000","journal-title":"Psychosom Med"},{"issue":"6","key":"pone.0246461.ref060","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/074823379901500606","article-title":"Development of a brief questionnaire for screening for multiple chemical sensitivity 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