{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:33:52Z","timestamp":1789104832020,"version":"build-2803163510"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800042"],"award-info":[{"award-number":["81800042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701586"],"award-info":[{"award-number":["81701586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Obstructive sleep apnea (OSA) are increasingly recognized as important features in diffuse parenchymal lung diseases (DPLDs) with differed prevalence and impact reported. The aim of this study is to systematically review the prevalence of comorbid OSA and characterize its impact on clinical and outcome measurements in adults with DPLDs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Publications addressing the prevalence of OSA in DPLDs and its impacts on DPLDs were selected from electronic databases. A random-effect model was used to estimate the pooled prevalence of OSA. Odds ratios (ORs) or mean differences (MDs) were used to assess the associations of OSA with clinical and outcome measurements. Heterogeneity was quantified by I<jats:sup>2<\/jats:sup> with 95% confidence interval (95% CI).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>4 studies comprising 643 participants were included. Overall, the pooled prevalence of OSA among DPLDs was 72% (95% CI: 65\u201379%; I<jats:sup>2<\/jats:sup> = 75.4%). Moderate-severe OSA was observed in 40% patients (95% CI: 28\u201352%; I<jats:sup>2<\/jats:sup> = 90.8%). The prevalence was higher as 76% in idiopathic pulmonary fibrosis (IPF) patients than in connective tissue associated-ILD or sarcoidosis (60%). Although oxygen desaturation during sleep was greater in OSA group compared with non-OSA patients, there was no difference in lung function or systematic comorbidities between the two groups. The associations between OSA and the mortality or disease progression of DPLDs were also systematically reviewed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In conclusion, OSA is a common comorbidity in DPLD patients, affecting approximately three in four patients, which may exacerbate the nocturnal desaturation and have negative influence on the outcomes. Larger studies with more homogeneous samples are warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0246878","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T23:45:29Z","timestamp":1613087129000},"page":"e0246878","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and impact of comorbid obstructive sleep apnoea in diffuse parenchymal lung diseases"],"prefix":"10.1371","volume":"16","author":[{"given":"Diandian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-6366","authenticated-orcid":true,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"issue":"2","key":"pone.0246878.ref001","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1164\/ajrccm.165.2.ats01","article-title":"American Thoracic Society\/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001","volume":"165","author":"American Thoracic S, European Respiratory S","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"pone.0246878.ref002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"WD Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"pone.0246878.ref003","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Clinical course and prediction of survival in idiopathic pulmonary fibrosis","volume":"183","author":"B Ley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"pone.0246878.ref004","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.chest.2017.07.019","article-title":"Sleep as a New Target for Improving Outcomes in Idiopathic Pulmonary Fibrosis","volume":"152","author":"C Mermigkis","year":"2017","journal-title":"Chest"},{"issue":"4","key":"pone.0246878.ref005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S2213-2600(19)30271-1","article-title":"Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial","volume":"8","author":"M S\u00e1nchez-de-la-Torre","year":"2020","journal-title":"The Lancet Respiratory Medicine"},{"issue":"4","key":"pone.0246878.ref006","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"R Heinzer","year":"2015","journal-title":"The Lancet Respiratory Medicine"},{"issue":"6","key":"pone.0246878.ref007","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"G Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"pone.0246878.ref008","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1152\/jappl.1991.70.1.430","article-title":"Upper airway muscle activity and the thoracic volume dependence of upper airway resistance","volume":"70","author":"RM Aronson","year":"1991","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"pone.0246878.ref009","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1164\/rccm.200404-552OC","article-title":"Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea","volume":"172","author":"RC Heinzer","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"pone.0246878.ref010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5664\/jcsm.2758","article-title":"Sleep oxygen desaturation predicts survival in idiopathic pulmonary fibrosis","volume":"9","author":"L Kolilekas","year":"2013","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"pone.0246878.ref011","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11325-014-1033-6","article-title":"Obstructive sleep apnea should be treated in patients with idiopathic pulmonary fibrosis","volume":"19","author":"C Mermigkis","year":"2015","journal-title":"Sleep Breath"},{"issue":"6","key":"pone.0246878.ref012","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01934-2016","article-title":"Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis","volume":"49","author":"T Gille","year":"2017","journal-title":"Eur Respir J"},{"issue":"3","key":"pone.0246878.ref013","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1378\/chest.08-2776","article-title":"Obstructive sleep apnea is common in idiopathic pulmonary fibrosis","volume":"136","author":"LH Lancaster","year":"2009","journal-title":"Chest"},{"issue":"4","key":"pone.0246878.ref014","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/qjmed\/hcu175","article-title":"Disordered breathing during sleep and exercise in idiopathic pulmonary fibrosis and the role of biomarkers","volume":"108","author":"RN Lee","year":"2015","journal-title":"QJM"},{"key":"pone.0246878.ref015","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"A Liberati","year":"2009","journal-title":"BMJ"},{"issue":"4","key":"pone.0246878.ref016","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jaci.2019.12.906","article-title":"Prevalence and impact of comorbid laryngeal dysfunction in asthma: A systematic review and meta-analysis","volume":"145","author":"J-H Lee","year":"2020","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"6","key":"pone.0246878.ref017","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/sim.650","article-title":"A comparison of statistical methods for meta-analysis","volume":"20","author":"SE Brockwell","year":"2001","journal-title":"Stat Med"},{"issue":"2","key":"pone.0246878.ref018","doi-asserted-by":"crossref","first-page":"e0211455","DOI":"10.1371\/journal.pone.0211455","article-title":"Impact of moderate to severe obstructive sleep apnea on the cognition in idiopathic pulmonary fibrosis","volume":"14","author":"V Tudorache","year":"2019","journal-title":"Plos One"},{"issue":"5","key":"pone.0246878.ref019","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00408-017-0031-4","article-title":"OSA and Prolonged Oxygen Desaturation During Sleep are Strong Predictors of Poor Outcome in IPF","volume":"195","author":"M Bosi","year":"2017","journal-title":"Lung"},{"issue":"2","key":"pone.0246878.ref020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.29390\/cjrt-2018-005","article-title":"Obstructive sleep apnoea in patients with fibrotic diffuse parenchymal lung disease-characterization and treatment compliance assessment","volume":"54","author":"AV Cardoso","year":"2018","journal-title":"Can J Respir Ther"},{"issue":"2","key":"pone.0246878.ref021","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11325-017-1579-1","article-title":"Sleep disorders and health-related quality of life in patients with interstitial lung disease","volume":"22","author":"M Mavroudi","year":"2018","journal-title":"Sleep Breath"},{"issue":"3","key":"pone.0246878.ref022","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00408-007-9004-3","article-title":"Sleep-related breathing disorders in patients with idiopathic pulmonary fibrosis","volume":"185","author":"C Mermigkis","year":"2007","journal-title":"Lung"},{"issue":"4","key":"pone.0246878.ref023","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11325-010-0336-5","article-title":"How common is sleep-disordered breathing in patients with idiopathic pulmonary fibrosis?","volume":"14","author":"C Mermigkis","year":"2010","journal-title":"Sleep Breath"},{"issue":"10","key":"pone.0246878.ref024","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/resp.13549","article-title":"Nocturnal hypoxaemia is associated with adverse outcomes in interstitial lung disease","volume":"24","author":"LK Troy","year":"2019","journal-title":"Respirology"},{"key":"pone.0246878.ref025","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.12659\/MSM.914905","article-title":"Relation of Warrick Score and Polysomnographic Parameters in Patients with Interstitial Lung Disease","volume":"25","author":"S Sarac","year":"2019","journal-title":"Med Sci Monit"},{"issue":"4","key":"pone.0246878.ref026","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s11325-013-0834-3","article-title":"Obstructive sleep apnea is common in patients with interstitial lung disease","volume":"17","author":"A Pihtili","year":"2013","journal-title":"Sleep Breath"},{"issue":"12","key":"pone.0246878.ref027","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.5664\/jcsm.8090","article-title":"Obstructive Sleep Apnea in Patients With Fibrotic Interstitial Lung Disease and COPD","volume":"15","author":"XL Zhang","year":"2019","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"pone.0246878.ref028","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1001\/archinte.162.8.893","article-title":"Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study","volume":"162","author":"T Young","year":"2002","journal-title":"Arch Intern Med"},{"issue":"8","key":"pone.0246878.ref029","doi-asserted-by":"crossref","first-page":"941","DOI":"10.5664\/jcsm.6690","article-title":"Change in End-Expiratory Lung Volume During Sleep in Patients at Risk for Obstructive Sleep Apnea","volume":"13","author":"P Koo","year":"2017","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"pone.0246878.ref030","doi-asserted-by":"crossref","first-page":"e0171344","DOI":"10.1371\/journal.pone.0171344","article-title":"Sputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7","volume":"12","author":"J Guiot","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"pone.0246878.ref031","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11325-018-1760-1","article-title":"Measurement of fractional exhaled nitric oxide and nasal nitric oxide in male patients with obstructive sleep apnea","volume":"23","author":"D Zhang","year":"2019","journal-title":"Sleep Breath"},{"issue":"1","key":"pone.0246878.ref032","first-page":"41","article-title":"Elevated nocturnal desaturation index predicts mortality in interstitial lung disease","volume":"29","author":"TJ Corte","year":"2012","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"2","key":"pone.0246878.ref033","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11325-012-0716-0","article-title":"Should we routinely screen patients with idiopathic pulmonary fibrosis for nocturnal hypoxemia?","volume":"17","author":"G Pitsiou","year":"2013","journal-title":"Sleep Breath"},{"issue":"4","key":"pone.0246878.ref034","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s11325-013-0813-8","article-title":"CPAP therapy in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea: does it offer a better quality of life and sleep?","volume":"17","author":"C Mermigkis","year":"2013","journal-title":"Sleep Breath"},{"issue":"10","key":"pone.0246878.ref035","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/jama.1990.03440100097014","article-title":"The existence of publication bias and risk factors for its occurrence","volume":"263","author":"K Dickersin","year":"1990","journal-title":"JAMA"},{"issue":"11","key":"pone.0246878.ref036","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0895-4356(00)00242-0","article-title":"Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature","volume":"53","author":"JA Sterne","year":"2000","journal-title":"J Clin Epidemiol"},{"issue":"7249","key":"pone.0246878.ref037","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1136\/bmj.320.7249.1574","article-title":"Empirical assessment of effect of publication bias on meta-analyses","volume":"320","author":"AJ Sutton","year":"2000","journal-title":"BMJ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0246878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T23:45:48Z","timestamp":1613087148000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0246878"}},"subtitle":[],"editor":[{"given":"Paola","family":"Faverio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0246878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]}}}