{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:37:29Z","timestamp":1753439849285,"version":"3.40.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The utility of intravoxel incoherent motion (IVIM) related parameters in differentiation of hypovascular liver lesions is still unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>The purpose of this study was to evaluate the value of IVIM related parameters in comparison to apparent diffusion coefficient (ADC) for differentiation among intrahepatic mass-forming cholangiocarcinoma (IMC), and hypovascular liver metastases (HLM).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Seventy-four prospectively enrolled patients (21 IMC, and 53 HLM) underwent 1.5T magnetic resonance examination with IVIM diffusion-weighted imaging using seven <jats:italic>b<\/jats:italic> values (0\u2013800 s\/mm<jats:sup>2<\/jats:sup>). Two independent readers performed quantitative analysis of IVIM-related parameters and ADC. Interobserver reliability was tested using a intraclass correlation coefficient. ADC, true diffusion coefficient (<jats:italic>D<\/jats:italic>), perfusion-related diffusion coefficient (<jats:italic>D<\/jats:italic>*), and perfusion fraction (\u0192) were compared among the lesions using Kruskal-Wallis H test. The diagnostic accuracy of each parameter was assessed by receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>The interobserver agreement was good for ADC (0.802), and excellent for <jats:italic>D<\/jats:italic>, <jats:italic>D<\/jats:italic>*, and \u0192 (0.911, 0.927, and 0.942, respectively). ADC, and <jats:italic>D<\/jats:italic> values were significantly different among IMC and HLM (both <jats:italic>p<\/jats:italic> &lt; 0.05), while there was no significant difference among these lesions for \u0192 and <jats:italic>D<\/jats:italic>* (<jats:italic>p<\/jats:italic> = 0.101, and <jats:italic>p<\/jats:italic> = 0.612, respectively). ROC analysis showed higher diagnostic performance of <jats:italic>D<\/jats:italic> in comparison to ADC (AUC = 0.879 vs 0.821).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>IVIM-derived parameters in particular <jats:italic>D<\/jats:italic>, in addition to ADC, could help in differentiation between most common hypovascular malignant liver lesions, intrahepatic mass\u2014forming cholangiocarcinoma and hypovascular liver metastases.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0247301","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T02:50:29Z","timestamp":1613789429000},"page":"e0247301","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of quantitative diffusion-weighted imaging in characterization of hypovascular liver lesions: A prospective comparison of intravoxel incoherent motion derived 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