{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:16Z","timestamp":1791304276184,"version":"4.3.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The purpose of this retrospective study was to evaluate the risk factors for short-term postoperative complications in the 8 weeks after unilateral tibial plateau leveling osteotomy (TPLO) for cranial cruciate ligament rupture in small dogs weighing less than 15 kg. Medical records were retrospectively reviewed for 90 dogs weighing &lt;15 kg that underwent medial parapatellar arthrotomy with inspection of the meniscus and TPLO performed by the same surgeon between January 2012 and December 2017. The overall complication rate was 4.44% (4\/90 dogs). There were four cases of partial incisional dehiscence, none of which required surgical revision. Complications were significantly more likely in dogs that had undergone placement of a 2.4-mm TPLO plate. Overall, the complication rate was less than that in previous studies of dogs weighing &gt; 15kg. In this study, patients in which 2.4-mm TPLO plates were used were more likely to develop postoperative complications. Dogs weighing &lt;15 kg that underwent TPLO had good short-term outcomes with minimal complications. In our study, the overall complication rate after TPLO in dogs weighing &lt;15 kg is less than that historically reported in heavier dogs. Our data suggests that TPLO is a safe treatment option in small dogs with cranial cruciate ligament rupture.<\/jats:p>","DOI":"10.1371\/journal.pone.0247555","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T18:42:52Z","timestamp":1614278572000},"page":"e0247555","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk factors for short-term postoperative complications in the 8 weeks after tibial plateau leveling osteotomy in dogs weighing less than 15 kilograms: A retrospective study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-2243","authenticated-orcid":true,"given":"Karen","family":"Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos 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naturally occurring cranial cruciate ligament rupture surgically treated with tibial plateau leveling osteotomy: longitudinal clinical study of 412 cases","volume":"36","author":"AS Jandi","year":"2007","journal-title":"Vet Surg"},{"key":"pone.0247555.ref013","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1532-950X.2010.00663.x","article-title":"Predictive variables for complications after TPLO with stifle inspection by arthrotomy in 1000 consecutive dogs","volume":"39","author":"N Fitzpatrick","year":"2010","journal-title":"Vet Surg"},{"key":"pone.0247555.ref014","first-page":"249","article-title":"Complications associated with tibial plateau leveling osteotomy: a retrospective of 1519 procedures","volume":"55","author":"TJ Coletti","year":"2014","journal-title":"Can Vet J"},{"key":"pone.0247555.ref015","first-page":"375","article-title":"Effects of incision closure method on infection prevalence following tibial plateau leveling osteotomy in dogs","volume":"56","author":"C Atwood","year":"2015","journal-title":"Can Vet J"},{"key":"pone.0247555.ref016","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1111\/vsu.12958","article-title":"A prospective, randomized, double\u2010blinded, placebo\u2010controlled clinical study on postoperative antibiotherapy in 150 arthroscopy\u2010assisted tibial plateau leveling osteotomies in dogs","volume":"47","author":"DD Spencer","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0247555.ref017","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3415\/VCOT-16-07-0106","article-title":"Comparison of complications following tibial tuberosity advancement and tibial plateau levelling osteotomy in very large and giant dogs 50 kg or more in body weight","volume":"30","author":"EC Hans","year":"2017","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref018","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1532-950X.2014.12212.x","article-title":"Locking plate and screw fixation after tibial plateau leveling osteotomy reduces postoperative infection rate in dogs over 50 kg","volume":"44","author":"MA Solano","year":"2015","journal-title":"Vet Surg"},{"key":"pone.0247555.ref019","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1532-950X.2007.00348.x","article-title":"Comparison of surgical treatment options for cranial cruciate ligament disease in large\u2010breed dogs with excessive tibial plateau angle","volume":"37","author":"FM Duerr","year":"2008","journal-title":"Vet Surg"},{"key":"pone.0247555.ref020","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3415\/VCOT-11-09-0122","article-title":"Complications of tibial plateau levelling osteotomy in dogs","volume":"25","author":"MS Bergh","year":"2012","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref021","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/vsu.13337","article-title":"Influence of administration of antimicrobial medications after tibial plateau leveling osteotomy on surgical site infections: A retrospective study of 308 dogs","volume":"49","author":"A Clarke","year":"2020","journal-title":"Vet Surg"},{"key":"pone.0247555.ref022","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1532-950X.2014.12267.x","article-title":"Prospective surgical site infection surveillance in dogs","volume":"44","author":"R Turk","year":"2015","journal-title":"Vet Surg"},{"key":"pone.0247555.ref023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1532-950X.1988.tb00278.x","article-title":"Surgical wound infection rates in dogs and cats data from a teaching hospital","volume":"17","author":"PB Vasseur","year":"1988","journal-title":"Vet Surg"},{"key":"pone.0247555.ref024","unstructured":"Petazzoni M. TPLO in the small dog: 18 cases. Proceedings of the 12th European Society of Veterinary Orthopaedics and Traumatology Congress, Munich, Germany, September 10\u201312, 2004. p.258. (abstract)"},{"key":"pone.0247555.ref025","unstructured":"Vezzoni A, Taravella E: Proceedings, 3rd World Veterinary Orthopaedic Congress, ESVOT-VOS, 15th ESVOT Congress, Bologna, Italy, 15\u201318 September, 2010 p.306 (abstract)"},{"key":"pone.0247555.ref026","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1748-5827.2002.tb00009.x","article-title":"Caudal proximal tibial deformity and cranial cruciate ligament rupture in small\u2010breed dogs","volume":"43","author":"C Macias","year":"2002","journal-title":"J Small Anim Pract"},{"key":"pone.0247555.ref027","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3415\/VCOT-12-02-0018","article-title":"Comparative anatomy of the proximal tibia in healthy Labrador Retrievers and Yorkshire Terriers","volume":"26","author":"B Vedrine","year":"2013","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref028","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/vr.104491","article-title":"Long-term complications following tibial plateau levelling osteotomy in small dogs with tibial plateau angles > 30\u00b0","volume":"182","author":"R Knight","year":"2018","journal-title":"Vet Rec"},{"key":"pone.0247555.ref029","doi-asserted-by":"crossref","first-page":"396","DOI":"10.5326\/JAAHA-MS-6074","article-title":"Short-term complications associated with TPLO in dogs using 2.0 and 2.7 mm plates","volume":"50","author":"SD Garnett","year":"2014","journal-title":"J Am Anim Hospital Assoc"},{"key":"pone.0247555.ref030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3415\/VCOT-14-09-0135","article-title":"Tibial plateau levelling osteotomy in 69 small breed dogs using conically coupled 1.9\/2.5 mm locking plates","volume":"28","author":"G Cosenza","year":"2015","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref031","first-page":"373","article-title":"Long-term outcome after surgical treatment of cranial cruciate ligament rupture in small breed dogs. Comparison of tibial plateau leveling osteotomy and extra-articular stifle stabilization","volume":"43","author":"B Berger","year":"2015","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"issue":"3","key":"pone.0247555.ref032","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-0039-1700990","article-title":"Force plate gait analysis and clinical results after tibial plateau levelling osteotomy for cranial cruciate ligament rupture in small breed dogs","volume":"33","author":"A Hirokazu","year":"2020","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref033","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/jsap.12486","article-title":"Short-term outcome and complications of TPLO using anatomically contoured locking compression plates in small\/medium-breed dogs with \u201cexcessive\u201d tibial plateau angle","volume":"57","author":"DC Barnes","year":"2016","journal-title":"J Small Anim Pract"},{"key":"pone.0247555.ref034","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1532-950X.2014.12202.x","article-title":"Tibial plateau leveling osteotomy in small breed dogs with high tibial plateau angles using a 4\u2010hole 1.9\/2.5 mm locking T\u2010plate","volume":"43","author":"PG Witte","year":"2014","journal-title":"Vet Surg"},{"key":"pone.0247555.ref035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1748-5827.2009.00854.x","article-title":"Management of concurrent patellar luxation and cranial cruciate ligament rupture using modified tibial plateau levelling","volume":"51","author":"A Langenbach","year":"2010","journal-title":"J Small Anim Pract"},{"key":"pone.0247555.ref036","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3415\/VCOT-10-01-0015","article-title":"Tibial tuberosity transposition-advancement for treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in the dog","volume":"24","author":"R Yeadon","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0247555.ref037","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2460\/javma.236.8.887","article-title":"Severity of patellar luxation and frequency of concomitant cranial cruciate ligament rupture in dogs: 162 cases (2004\u20132007)","volume":"236","author":"CA Campbell","year":"2010","journal-title":"J Am Vet Med Assoc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0247555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T23:51:01Z","timestamp":1697932261000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0247555"}},"subtitle":[],"editor":[{"given":"L. 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