{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:41:40Z","timestamp":1783982500393,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Independent Research Fund Denmark","award":["CFC\/Grant no. 0134-00407B"],"award-info":[{"award-number":["CFC\/Grant no. 0134-00407B"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and objectives<\/jats:title>\n<jats:p>Only few smaller studies have examined if impaired kidney function increases the risk of acute kidney injury in patients with acute pyelonephritis. Therefore, we estimated 30-day risk of acute kidney injury by preadmission kidney function in patients with acute pyelonephritis. Furthermore, we examined if impaired kidney function was a risk factor for development of acute kidney injury in pyelonephritis patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This cohort study included patients with a first-time hospitalization with pyelonephritis from 2000 to 2017. Preadmission kidney function (estimated glomerular filtration rate (eGFR) &lt;30, 30\u201344, 45\u201359, 60\u201389, and \u226590 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>) and acute kidney injury within 30 days after admission were assessed using laboratory data on serum creatinine. The absolute 30-days risk of acute kidney injury was assessed treating death as a competing risk. The impact of eGFR on the odds of acute kidney injury was compared by odds ratios (ORs) with 95% confidence intervals estimated using logistic regression adjusted for potential confounding factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among 8,760 patients with available data on preadmission kidney function, 25.8% had a preadmission eGFR &lt;60. The 30-day risk of acute kidney injury was 16% among patients with preadmission eGFR \u226590 and increased to 22%, 33%, 42%, and 47% for patients with preadmission eGFR of 60\u201389, 45\u201359, 30\u201344, and &lt;30 respectively. Compared with eGFR\u226590, the adjusted ORs for the subgroups with eGFR 60\u201389, 45\u201359, 30\u201345, and &lt;30 were 0.95, 1.32, 1.78, and 2.19 respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Acute kidney injury is a common complication in patients hospitalized with acute pyelonephritis. Preadmission impaired kidney function is a strong risk factor for development of acute kidney injury in pyelonephritis patients and more attention should be raised in prevention of pyelonephritis in patients with a low kidney function.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0247687","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T21:05:52Z","timestamp":1614805552000},"page":"e0247687","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preadmission kidney function and risk of acute kidney injury in patients hospitalized with acute pyelonephritis: A Danish population-based cohort study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-8690","authenticated-orcid":true,"given":"Henriette Vendelbo","family":"Graversen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"N\u00f8rgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-953X","authenticated-orcid":true,"given":"Christian Fynbo","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"12","key":"pone.0247687.ref001","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrurol.2010.190","article-title":"The epidemiology of urinary tract infection","volume":"7","author":"B Foxman","year":"2010","journal-title":"Nat Rev Urol"},{"issue":"3","key":"pone.0247687.ref002","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/519268","article-title":"Population-based epidemiologic analysis of acute pyelonephritis","volume":"45","author":"CA Czaja","year":"2007","journal-title":"Clin Infect Dis"},{"key":"pone.0247687.ref003","doi-asserted-by":"crossref","unstructured":"Kidney Disease Improving Global Outcomes. 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Immigrants and their descendants Statistics Denmark: Statistics Denmark; 2020 [Available from: https:\/\/www.dst.dk\/en\/Statistik\/emner\/befolkning-og-valg\/indvandrere-og-efterkommere\/indvandrere-og-efterkommere."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0247687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T21:06:51Z","timestamp":1614805611000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0247687"}},"subtitle":[],"editor":[{"given":"Bhagwan","family":"Dass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0247687","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]}}}