{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:20:44Z","timestamp":1784161244760,"version":"3.55.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cervical cancer is considered to be particularly amenable to prevention and highly treatable in its early stages. The real-time optoelectronic method of cervix examination seemed to be very promising in the detection of cervical squamous intraepithelial lesions and demonstrated relatively good efficacy. Although this method was introduced into clinics almost 10 years ago, it has not found its place in diagnostic schemes. At the moment, cytological smears and HPV detection with genotyping are still essential. TruScreen seems to be a slightly forgotten test. The aim of the study was to evaluate the efficacy and accuracy of TruScreen in detecting cervical pathology: CIN and cervical cancer confirmed with a histopathological diagnosis in comparison with other methods\u2013cytology and colposcopy over four years of observations. The study was conducted on 130 women with abnormal Pap smear results. We can conclude that a real-time optoelectronic method like TruScreen can be useful as an effective initial cervical cancer screening in developing countries, possibly in combination with other methods. The combination of cytology and TruScreen examination may help clinicians to take decision about the next diagnostics steps (e.g. colposcopy) and contribute to better primary screening for cervical cancer.<\/jats:p>","DOI":"10.1371\/journal.pone.0247702","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T18:34:58Z","timestamp":1614364498000},"page":"e0247702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of a real-time optoelectronic method in the diagnostics of CIN over four years of observations"],"prefix":"10.1371","volume":"16","author":[{"given":"Barbara","family":"Sucho\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-7122","authenticated-orcid":true,"given":"Wanda","family":"Gajzlerska-Majewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Wielgo\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"pone.0247702.ref001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5858\/2004-128-17-COPOCA","article-title":"Comparison of performance of conventional and ThinPrep gynecologic preparations in the College of American Pathologists Gynecologic Cytology Program","volume":"128","author":"A Renshaw","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"pone.0247702.ref002","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2478\/s11772-011-0040-4","article-title":"Optoelectronic method for detection of cervical intraepithelial neoplasia and cervical cancer","volume":"19","author":"D Pruski","year":"2011","journal-title":"Opto-electron Rev"},{"key":"pone.0247702.ref003","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1525-1438.1994.04020079.x","article-title":"An electronic approach to the detection of pre-cancer and cancer of the uterine cervix; a preliminary evaluation of Polarprobe","volume":"4","author":"M Coppleson","year":"1994","journal-title":"Int J Gynecol Cancer"},{"key":"pone.0247702.ref004","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/ijgc-00009577-200311000-00011","article-title":"A real time optoelectronic device as an adjunct to the Pap smear for cervical screening: a multicentre evaluation","volume":"13","author":"A Singer","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"pone.0247702.ref005","doi-asserted-by":"crossref","first-page":"e11439","DOI":"10.1097\/MD.0000000000011439","article-title":"The diagnostic accuracy of a real-time optoelectronic device in cervical cancer screening A PRISMA-compliant systematic review and meta-analysis","volume":"97","author":"H Yang","year":"2018","journal-title":"Medicine"},{"key":"pone.0247702.ref006","unstructured":"Pruski D, Przybylski M, K\u0119dzia W, K\u0119dzia H, Jagielska-Pruska J, Spaczy\u0144ski M. 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