{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:44:01Z","timestamp":1788810241117,"version":"build-2803163510"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009846","name":"Nova Southeastern University","doi-asserted-by":"publisher","award":["335317"],"award-info":[{"award-number":["335317"]}],"id":[{"id":"10.13039\/100009846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005792","name":"Louisiana Sea Grant, Louisiana State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Metaplasia is a well documented and deleterious effect of crude oil components on oysters. This reversible transformation of one cell type to another is a common response to petroleum-product exposure in molluscs. It has been shown experimentally in previous work that eastern oysters (\n                    <jats:italic>Crassostrea virginica<\/jats:italic>\n                    ) exposed to petroleum products will exhibit metaplasia of digestive tissues. Here we document for the first time that wild adult oysters inhabiting coastal waters in the northern Gulf of Mexico during and in the aftermath of the Deepwater Horizon oil spill (2010) exhibited metaplasia in both ctenidial (respiratory and suspension feeding) and digestive tract tissues at significantly higher frequencies than geographic controls of\n                    <jats:italic>C. virginica<\/jats:italic>\n                    from Chesapeake Bay. Metaplasia included the loss of epithelial cilia, transformations of columnar epithelia, hyperplasia and reduction of ctenidial branches, and vacuolization of digestive tissues. Evidence for a reduction of metaplasia following the oil spill (2010-2013) is suggestive but equivocal.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0247739","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T13:59:16Z","timestamp":1631023156000},"page":"e0247739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metaplasia of respiratory and digestive tissues in the eastern oyster Crassostrea virginica associated with the Deepwater Horizon oil spill"],"prefix":"10.1371","volume":"16","author":[{"given":"Deanne S.","family":"Roopnarine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-1176","authenticated-orcid":true,"given":"Peter D.","family":"Roopnarine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie 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