{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:24:16Z","timestamp":1789683856751,"version":"4.0.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The duration of percutaneous transhepatic biliary drainage (PTBD) is a critical factor that determines the duration of treatment. This study aimed to evaluate factors affecting the PTBD duration in patients who underwent percutaneous treatment of common bile duct (CBD) stones. This study analyzed data of 169 patients who underwent percutaneous treatment of CBD stones from June 2009 to June 2019. Demographic data, characteristics of stone, procedure-related factors, and laboratory findings before the insertion of PTBD tubes were retrospectively evaluated. To assess the effect of confounding factors on the PTBD duration, multivariate linear regression analysis was applied, incorporating significant predictive factors identified in the univariate regression analysis. In the univariate regression analysis, the predictive factor that showed high correlation with the PTBD duration was the initial total bilirubin level (coefficient = 0.68, <jats:italic>P<\/jats:italic> &lt; .001) followed by the short diameter of the largest stone (coefficient = 0.19, <jats:italic>P<\/jats:italic> = .056), and previous endoscopic sphincterotomy (coefficient = -2.50, <jats:italic>P<\/jats:italic> = .086). The multivariate linear regression analysis showed that the initial total bilirubin level (coefficient = 0.50, <jats:italic>P<\/jats:italic> &lt; .001) and short diameter of the largest stone (coefficient = 0.16, <jats:italic>P<\/jats:italic> = .025) were significantly related to the PTBD duration. The total bilirubin level before PTBD tube insertion and the short diameter of the largest CBD stone were predictive factors for the PTBD duration in patients who underwent percutaneous CBD stone removal. Careful assessment of these factors might help in predicting the treatment period, thereby improving the quality of patient care.<\/jats:p>","DOI":"10.1371\/journal.pone.0248003","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T18:48:19Z","timestamp":1614710899000},"page":"e0248003","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictive factors affecting percutaneous drainage duration in the percutaneous treatment of common bile duct stones"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-5724","authenticated-orcid":true,"given":"Min Uk","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-2007","authenticated-orcid":true,"given":"Yoontaek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Buem","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"pone.0248003.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2214\/ajr.157.1.2048504","article-title":"Oriental cholangiohepatitis: pathologic, clinical, and radiologic features","volume":"157","author":"JH Lim","year":"1991","journal-title":"AJR Am J Roentgenol"},{"key":"pone.0248003.ref002","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3348\/jkrs.2008.58.3.229","article-title":"Percutaneous lithotripsy for removing difficult bile duct stones using endoscopy","volume":"58","author":"SH Kim","year":"2008","journal-title":"J Korean Radiol Soc"},{"key":"pone.0248003.ref003","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0016-5107(74)73914-1","article-title":"Endoscopic sphincterotomy of the ampulla of Vater","volume":"20","author":"K Kawai","year":"1974","journal-title":"Gastrointest Endosc"},{"key":"pone.0248003.ref004","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(89)90602-8","article-title":"Endoscopic sphincterotomy in 1000 consecutive patients","volume":"334","author":"D Vaira","year":"1989","journal-title":"Lancet"},{"key":"pone.0248003.ref005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1148\/radiology.160.2.3726136","article-title":"Bile duct stones: percutaneous transhepatic removal","volume":"160","author":"ME Clouse","year":"1986","journal-title":"Radiology"},{"key":"pone.0248003.ref006","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1155\/1999\/847954","article-title":"Intrahepatic stones: the percutaneous approach","volume":"13","author":"H Neuhaus","year":"1999","journal-title":"Can J Gastroenterol"},{"key":"pone.0248003.ref007","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3348\/kjr.2005.6.4.235","article-title":"Percutaneous treatment of extrahepatic bile duct stones assisted by balloon sphincteroplasty and occlusion balloon","volume":"6","author":"YS Park","year":"2005","journal-title":"Korean J Radiol"},{"key":"pone.0248003.ref008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3904\/kjm.2012.83.1.65","article-title":"PTPBD for managing extrahepatic bile duct stones in patients with failed or contraindicated ERCP","volume":"83","author":"HG Seon","year":"2012","journal-title":"Korean J Med"},{"key":"pone.0248003.ref009","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00270-011-0190-2","article-title":"Percutaneous transhepatic removal of bile duct stones: results of 261 patients","volume":"35","author":"N Ozcan","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"key":"pone.0248003.ref010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jhbp.515","article-title":"Tokyo Guidelines 2018 diagnostic criteria and severity grading of acute cholecystitis","volume":"25","author":"M Yokoe","year":"2018","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"pone.0248003.ref011","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/oxfordjournals.aje.a116813","article-title":"Simulation study of confounder-selection strategies","volume":"138","author":"G Maldonado","year":"1993","journal-title":"Am J Epidemiol"},{"key":"pone.0248003.ref012","first-page":"278","article-title":"Technic of blood extraction of calculi in residual lithasis of the choledochus","volume":"46","author":"AF Mondet","year":"1962","journal-title":"Bol Trab Soc Cir B Aires"},{"key":"pone.0248003.ref013","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2214\/ajr.134.5.889","article-title":"Garland lecture. Percutaneous extraction of retained biliary tract stones: 661 patients","volume":"134","author":"HJ Burhenne","year":"1980","journal-title":"AJR Am J Roentgenol"},{"key":"pone.0248003.ref014","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2214\/ajr.117.2.388","article-title":"Nonoperative retained biliary tract stone extraction: a new roentgenologic technique","volume":"117","author":"HJ Burhenne","year":"1973","journal-title":"AJR Am J Roentgenol"},{"key":"pone.0248003.ref015","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2214\/ajr.174.5.1741455","article-title":"Effectiveness and safety of balloon dilation of the papilla and the use of an occlusion balloon for clearance of bile duct calculi","volume":"174","author":"S Gil","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"pone.0248003.ref016","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0016-5107(00)70441-X","article-title":"Percutaneous treatment of bile duct stones in patients treated unsuccessfully with endoscopic retrograde procedures","volume":"51","author":"JJ van der Velden","year":"2000","journal-title":"Gastrointest Endosc"},{"key":"pone.0248003.ref017","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/gut.51.2.245","article-title":"A randomised controlled trial of endoscopic sphincterotomy in acute cholangitis without common bile duct stones","volume":"51","author":"CK Hui","year":"2002","journal-title":"Gut"},{"key":"pone.0248003.ref018","first-page":"1407","article-title":"Endoscopic mechanical lithotripsy of difficult common bile duct stones","volume":"84","author":"L Cipolletta","year":"1997","journal-title":"Br J Surg"},{"key":"pone.0248003.ref019","first-page":"730","article-title":"Results of a multicenter trial using a mechanical lithotripter for the treatment of large bile duct stones","volume":"88","author":"MJ Shaw","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"pone.0248003.ref020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0016-5107(04)00295-0","article-title":"Predictors of unsuccessful mechanical lithotripsy and endoscopic clearance of large bile duct stones.","volume":"59","author":"PK Garg","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"pone.0248003.ref021","doi-asserted-by":"crossref","first-page":"279607","DOI":"10.5402\/2011\/279607","article-title":"The predictivity of serum biochemical markers in acute biliary pancreatitis","volume":"2011","author":"B G\u00fcng\u00f6r","year":"2011","journal-title":"ISRN Gastroenterol"},{"key":"pone.0248003.ref022","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/000313480807401020","article-title":"Total bilirubin is a useful predictor of persisting common bile duct stone in gallstone pancreatitis.","volume":"74","author":"T Chan","year":"2008","journal-title":"Am Surg"},{"key":"pone.0248003.ref023","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.kjms.2017.12.016","article-title":"Simplified scoring system for prediction of mortality in acute suppurative cholangitis","volume":"34","author":"BD Y\u0131ld\u0131z","year":"2018","journal-title":"Kaohsiung J Med Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T18:48:44Z","timestamp":1614710924000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248003"}},"subtitle":[],"editor":[{"given":"Yutaka","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0248003","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,2]]}}}