{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:44:14Z","timestamp":1791251054806,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka"},{"name":"United States Public Health Service, National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["U19AI115658"],"award-info":[{"award-number":["U19AI115658"]}]},{"name":"United States Public Health Service, National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["U19AI115658"],"award-info":[{"award-number":["U19AI115658"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    In tropical countries such as Sri Lanka, where leptospirosis\u2014a deadly disease with a high mortality rate\u2014is endemic, prediction is required for public health planning and resource allocation. Routinely collected meteorological data may offer an effective means of making such predictions. This study included monthly leptospirosis and meteorological data from January 2007 to April 2019 from Sri Lanka. Factor analysis was first used with rainfall data to classify districts into meteorological zones. We used a seasonal autoregressive integrated moving average (SARIMA) model for univariate predictions and an autoregressive distributed lag (ARDL) model for multivariable analysis of leptospirosis with monthly average rainfall, temperature, relative humidity (RH), solar radiation (SR), and the number of rainy days\/month (RD). Districts were classified into wet (WZ) and dry (DZ) zones, and highlands (HL) based on the factor analysis of rainfall data. The WZ had the highest leptospirosis incidence; there was no difference in the incidence between the DZ and HL. Leptospirosis was fluctuated positively with rainfall, RH and RD, whereas temperature and SR were fluctuated negatively. The best-fitted SARIMA models in the three zones were different from each other. Despite its known association, rainfall was positively significant in the WZ only at lag 5 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03) but was negatively associated at lag 2 and 3 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.04). RD was positively associated for all three zones. Temperature was positively associated at lag 0 for the WZ and HL (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.009) and was negatively associated at lag 1 for the WZ (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01). There was no association with RH in contrast to previous studies. Based on altitude and rainfall data, meteorological variables could effectively predict the incidence of leptospirosis with different models for different climatic zones. These predictive models could be effectively used in public health planning purposes.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0248032","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T13:45:17Z","timestamp":1620999917000},"page":"e0248032","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Time series models for prediction of leptospirosis in different climate zones in Sri Lanka"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-6851","authenticated-orcid":true,"given":"Janith","family":"Warnasekara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneth","family":"Agampodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupika","family":"Abeynayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"pone.0248032.ref001","doi-asserted-by":"crossref","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0248032.ref002","doi-asserted-by":"crossref","first-page":"e0004122","DOI":"10.1371\/journal.pntd.0004122","article-title":"Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years","volume":"9","author":"PR Torgerson","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0248032.ref003","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1017\/S0950268813001465","article-title":"Outbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka?","volume":"142","author":"SB Agampodi","year":"2014","journal-title":"Epidemiol Infect"},{"key":"pone.0248032.ref004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12992-014-0061-0","article-title":"Globalization of leptospirosis through travel and migration","volume":"10","author":"M Bandara","year":"2014","journal-title":"Global Health"},{"key":"pone.0248032.ref005","article-title":"Leptospira and leptospirosis","author":"S Faine","year":"1994","journal-title":"Leptospira and leptospirosis"},{"key":"pone.0248032.ref006","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1089\/vbz.2010.0153","article-title":"Prevalence and carrier status of leptospirosis in smallholder dairy cattle and peridomestic rodents in Kandy, Sri Lanka","volume":"11","author":"CD Gamage","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"key":"pone.0248032.ref007","doi-asserted-by":"crossref","first-page":"e027850","DOI":"10.1136\/bmjopen-2018-027850","article-title":"Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study","volume":"9","author":"S Agampodi","year":"2019","journal-title":"BMJ Open"},{"key":"pone.0248032.ref008","volume-title":"Climate change: socioeconomic effects","author":"J Blanco","year":"2011"},{"key":"pone.0248032.ref009","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1590\/s1678-9946201860039","article-title":"Temporal analysis of the relationship between leptospirosis, rainfall levels and seasonality, Santa Catarina, Brazil, 2005\u20132015","volume":"60","author":"J Ghizzo Filho","year":"2018","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"pone.0248032.ref010","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12879-017-2506-6","article-title":"The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study","volume":"17","author":"YP Joshi","year":"2017","journal-title":"BMC Infect Dis"},{"key":"pone.0248032.ref011","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1017\/S095026881600203X","article-title":"Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines","volume":"145","author":"A Sumi","year":"2017","journal-title":"Epidemiol Infect"},{"key":"pone.0248032.ref012","doi-asserted-by":"crossref","first-page":"e20377","DOI":"10.1371\/journal.pone.0020377","article-title":"Seasonality of Human Leptospirosis in Reunion Island (Indian Ocean) and Its Association with Meteorological Data","volume":"6","author":"A Desvars","year":"2011","journal-title":"PLoS One"},{"key":"pone.0248032.ref013","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1995-7645(12)60095-9","article-title":"Modeling seasonal leptospirosis transmission and its association with rainfall and temperature in Thailand using time-series and ARIMAX analyses","volume":"5","author":"S Chadsuthi","year":"2012","journal-title":"Asian Pac J Trop Med"},{"key":"pone.0248032.ref014","article-title":"Leptospira and Rodents in Cambodia: Environmental Determinants of Infection","volume":"86","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0248032.ref015","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1890\/0012-9658(2002)083[3449:IACDOP]2.0.CO;2","article-title":"Intrisic and climatic determinants of population demography: The winter dynamics of Tundra Voles","volume":"83","author":"J Aars","year":"2002","journal-title":"Ecology"},{"key":"pone.0248032.ref016","article-title":"Seasonal Rainfall Variability, the Incidence of Hemorrhagic Fever With Renal Syndrome, and Prediction of the Disease in Low-Lying Areas of China","volume":"148","year":"1998","journal-title":"Am J Epidemiol"},{"key":"pone.0248032.ref017","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4269\/ajtmh.2011.11-0276","article-title":"Leptospirosis outbreak in Sri Lanka in 2008: lessons for assessing the global burden of disease","volume":"85","author":"SB Agampodi","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0248032.ref018","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4038\/sljid.v7i2.8155","article-title":"Leptospirosis in Sri Lanka","volume":"7","author":"JN Warnasekara","year":"2017","journal-title":"Sri Lankan J Infect Dis"},{"key":"pone.0248032.ref019","doi-asserted-by":"crossref","first-page":"1553283","DOI":"10.1080\/16549716.2018.1553283","article-title":"The correlation between local weather and leptospirosis incidence in Kandy district, Sri Lanka from 2006 to 2015","volume":"12","author":"NDB Ehelepola","year":"2019","journal-title":"Glob Health Action"},{"key":"pone.0248032.ref020","first-page":"27","article-title":"Outbreaks of Leptospirosis in selected districts of Sri Lanka","volume":"3","author":"SR Gnanapragasam","year":"2018","journal-title":"Int J Acad Res Dev"},{"key":"pone.0248032.ref021","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4038\/ouslj.v12i1.7354","article-title":"An Empirical Study on Human Leptospirosis Cases in the Western Province of Sri Lanka","volume":"12","author":"SR Gnanapragasam","year":"2017","journal-title":"OUSL J"},{"key":"pone.0248032.ref022","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1017\/S0950268811001014","article-title":"Spatial epidemiology of suspected clinical leptospirosis in Sri Lanka","volume":"140","author":"C Robertson","year":"2012","journal-title":"Epidemiol Infect"},{"key":"pone.0248032.ref023","doi-asserted-by":"crossref","first-page":"e0245366","DOI":"10.1371\/journal.pone.0245366","article-title":"The interrelationship between meteorological parameters and leptospirosis incidence in Hambantota district, Sri Lanka 2008\u20132017 and practical implications","volume":"16","author":"NDB Ehelepola","year":"2021","journal-title":"PLoS One"},{"key":"pone.0248032.ref024","author":"CCF Plouffe","year":"2016","journal-title":"Space-time modelling of emerging infectious diseases: Assessing leptospirosis risk in Sri Lanka"},{"key":"pone.0248032.ref025","unstructured":"Epidemiology Unit, Sri Lanka. http:\/\/www.epid.gov.lk\/web\/index.php?lang=en. Accessed 12 Oct 2019."},{"key":"pone.0248032.ref026","unstructured":"Meteorology department, Sri Lanka. http:\/\/www.meteo.gov.lk\/index.php?lang=en. Accessed 12 Oct 2019."},{"key":"pone.0248032.ref027","unstructured":"Lanka S. Surveillance Case Definitions for Notifiable Diseases. 2005. http:\/\/medicine.kln.ac.lk\/depts\/publichealth\/Fixed_Learning\/Surveillance\/Definition\/Final-Book.pdf. Accessed 29 Jun 2017."},{"key":"pone.0248032.ref028","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12879-018-3655-y","article-title":"Estimating the burden of leptospirosis in Sri Lanka; a systematic review","volume":"19","author":"J Warnasekara","year":"2019","journal-title":"BMC Infect Dis"},{"key":"pone.0248032.ref029","doi-asserted-by":"crossref","first-page":"e2626","DOI":"10.1371\/journal.pntd.0002626","article-title":"Regional differences of leptospirosis in Sri Lanka: observations from a flood-associated outbreak in 2011","volume":"8","author":"SB Agampodi","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0248032.ref030","first-page":"63","article-title":"Autoregressive Distributed Lag (ARDL) cointegration technique: application and interpretation","volume":"5","author":"E Nkoro","year":"2016","journal-title":"J Stat Econom Methods"},{"key":"pone.0248032.ref031","doi-asserted-by":"crossref","first-page":"105249","DOI":"10.1016\/j.aap.2019.07.025","article-title":"Bayesian spatial-temporal model for the main and interaction effects of roadway and weather characteristics on freeway crash incidence","volume":"132","author":"H Wen","year":"2019","journal-title":"Accid Anal Prev"},{"key":"pone.0248032.ref032","first-page":"15","article-title":"An empirical investigation of the factors contributing to local-vehicle and non-local-vehicle crashes on freeway","volume":"1","author":"Q Zeng","year":"2020","journal-title":"J Transp Saf Secur"},{"key":"pone.0248032.ref033","doi-asserted-by":"crossref","first-page":"e0009272","DOI":"10.1371\/journal.pntd.0009272","article-title":"12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka","volume":"15","author":"D Jayasundara","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0248032.ref034","first-page":"1","article-title":"Leptospira interrogans Retains Direct Virulence After Long Starvation in Water","author":"E Bierque","year":"2020","journal-title":"Curr Microbiol"},{"key":"pone.0248032.ref035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/ije\/31.1.189","article-title":"Climatic, reservoir and occupational variables and the transmission of haemorrhagic fever with renal syndrome in China","volume":"31","year":"2002","journal-title":"Int J Epidemiol"},{"key":"pone.0248032.ref036","article-title":"Outbreak of Hantavirus Infection in the Four Corners Region of the United States in the Wake of the 1997\u20131998 El Nino-southern Oscillation","volume":"181","year":"2000","journal-title":"J Infect Dis"},{"key":"pone.0248032.ref037","article-title":"Spatiotemporal Trends and Climatic Factors of Hemorrhagic Fever With Renal Syndrome Epidemic in Shandong Province, China","volume":"4","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0248032.ref038","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3346\/jkms.2013.28.10.1552","article-title":"Epidemiology of Hemorrhagic Fever with Renal Syndrome in Korea, 2001\u20132010","volume":"28","author":"S-H Lee","year":"2013","journal-title":"J Korean Med Sci"},{"key":"pone.0248032.ref039","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/tbed.12014","article-title":"Carrier status of leptospirosis among cattle in Sri Lanka: a zoonotic threat to public health","volume":"61","author":"CD Gamage","year":"2014","journal-title":"Transbound Emerg Dis"},{"key":"pone.0248032.ref040","article-title":"Comparison of the effects of UV-A radiation on Leptospira interrogan serovar Bataviae, Canicola and Pomona | African Journal of Biotechnology","volume":"9","author":"S Chadsuthi","year":"2010","journal-title":"African J Biotechnol"},{"key":"pone.0248032.ref041","article-title":"Leptospirosis research: Response of pathogenic spirochete to ultaviolet-A irradiation","author":"G Doungchawee","year":"2010","journal-title":"African J"},{"key":"pone.0248032.ref042","article-title":"Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka","author":"I Senevirathna","year":"2020","journal-title":"J Genomics"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0318175","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000}}],"container-title":["PLOS 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