{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:17:09Z","timestamp":1770297429790,"version":"3.49.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>There is limited data on the markers of coagulation and hemostatic activation (MOCHA) profile in Coronavirus disease 2019 (COVID-19) and its ability to identify COVID-19 patients at risk for thrombotic events and other complications.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Hospitalized patients with confirmed SARS-COV-2 from four Atlanta hospitals were included in this observational cohort study and underwent admission testing of MOCHA parameters (plasma d-dimer, prothrombin fragment 1.2, thrombin-antithrombin complex, fibrin monomer). Clinical outcomes included deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke, access line thrombosis, ICU admission, intubation and mortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Main results<\/jats:title>\n<jats:p>Of 276 patients (mean age 59 \u00b1 6.4 years, 47% female, 62% African American), 45 (16%) had a thrombotic endpoint. Each MOCHA parameter was independently associated with a thrombotic event (p&lt;0.05) and \u2265 2 abnormalities was associated with thrombotic endpoints (OR 3.3, 95% CI 1.2\u20138.8) as were admission D-dimer \u2265 2000 ng\/mL (OR 3.1, 95% CI 1.5\u20136.6) and \u2265 3000 ng\/mL (OR 3.6, 95% CI 1.6\u20137.9). However, only \u2265 2 MOCHA abnormalities were associated with ICU admission (OR 3.0, 95% CI 1.7\u20135.2) and intubation (OR 3.2, 95% CI 1.6\u20136.4). MOCHA and D-dimer cutoffs were not associated with mortality. MOCHA with &lt;2 abnormalities (26% of the cohort) had 89% sensitivity and 93% negative predictive value for a thrombotic endpoint.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>An admission MOCHA profile is useful to risk-stratify COVID-19 patients for thrombotic complications and more effective than isolated d-dimer for predicting risk of ICU admission and intubation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0248230","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T22:05:14Z","timestamp":1616191514000},"page":"e0248230","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validation of an admission coagulation panel for risk stratification of COVID-19 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