{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:21Z","timestamp":1787022081616,"version":"build-2736575974"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Background<\/jats:title>\n \n Bone and joint infections (BJIs) due to\n Streptococcus agalactiae<\/jats:italic>\n are rare but has been described to increase in the past few years. The objective of this study was to describe clinical features and outcomes of cases of\n S<\/jats:italic>\n . BJIs.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective analysis of adult cases of\n S<\/jats:italic>\n .\n agalactiae<\/jats:italic>\n BJIs that occurred between January 2009 and June 2015 in a French university hospital. The treatment success was assessed until 24 months after the end of antibiotic treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among the 26 patients included, 20 (77%) were male, mean age was 62 years \u00b1 13 and mean Charlson comorbidity index score was 4.9 \u00b1 3.2. Diabetes mellitus was the most common comorbidity (n = 14, 54%). Six had PJI (Prosthetic Joint Infections), five osteosynthesis-associated infections, 11 osteomyelitis and four native septic arthritis.<\/jats:p>\n \n Eleven patients had a delayed or late infection: six with a prosthetic joint infection and five with an internal fixation device infection. Sixteen patients (62%) had a polymicrobial BJI, most commonly with Gram-positive cocci (75%) notably\n Staphylococcus aureus<\/jats:italic>\n (44%). Polymicrobial infections were more frequently found in foot infections (90% vs 44%,\n p<\/jats:italic>\n = 0.0184). During the two-year follow-up, three patients died (3\/25, 12%) and seven (7\/25, 28%) had treatment failure.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Diabetes mellitus was the most common comorbidity. We observed an heterogenous management and a high rate of relapse.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0248231","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T13:31:55Z","timestamp":1615555915000},"page":"e0248231","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and outcome of Streptococcus agalactiae bone and joint infections over a 6-year period in a French university 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