{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:48:19Z","timestamp":1763664499578,"version":"3.40.5"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>This study aimed to assess the risk factors and impact of rhabdomyolysis on treatments, outcomes, and resource utilization in hospitalized patients for salicylate intoxication in the United States.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>The National Inpatient Sample was utilized to identify hospitalized patients with a primary diagnosis of salicylate intoxication from 2003\u20132014. Rhabdomyolysis was identified using hospital diagnosis code. We compared the clinical characteristics, in-hospital treatment, outcomes, and resource utilization between patients with and without rhabdomyolysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 13,805 hospital admissions for salicylate intoxication were studied. Of these, rhabdomyolysis developed in 258 (1.9%) admissions. The risk factors for rhabdomyolysis were age&gt;20 years, male sex, volume depletion, hypokalemia, sepsis, and seizure. After adjustment for baseline clinical characteristics, salicylate intoxication patients with rhabdomyolysis required more invasive mechanical ventilation, and renal replacement therapy. Rhabdomyolysis was significantly associated with higher risk of failure of any organ systems, and in-hospital mortality. Length of hospital stay and hospitalization cost were higher when rhabdomyolysis occurred during hospital stay.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Rhabdomyolysis was not common in hospitalized patients for salicylate intoxication but it was associated with increased morbidity, mortality, and resource utilization.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0248242","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T18:26:40Z","timestamp":1615228000000},"page":"e0248242","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rhabdomyolysis among hospitalized patients for salicylate intoxication in the United States: Nationwide inpatient sample 2003\u20132014"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-7235","authenticated-orcid":true,"given":"Wisit","family":"Kaewput","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charat","family":"Thongprayoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tananchai","family":"Petnak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisit","family":"Cheungpasitporn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boonphiphop","family":"Boonpheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saraschandra","family":"Vallabhajosyula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Bathini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail Abdul","family":"Salim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"issue":"4","key":"pone.0248242.ref001","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3810\/pgm.2009.07.2041","article-title":"Salicylate intoxication: a clinical review","volume":"121","author":"BL Pearlman","year":"2009","journal-title":"Postgrad Med"},{"issue":"12","key":"pone.0248242.ref002","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/15563650.2019.1677022","article-title":"2018 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 36th Annual Report","volume":"57","author":"DD Gummin","year":"2019","journal-title":"Clin Toxicol (Phila)"},{"issue":"26","key":"pone.0248242.ref003","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMra2010852","article-title":"Salicylate Toxicity","volume":"382","author":"BF Palmer","year":"2020","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"pone.0248242.ref004","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0735-6757(89)90049-1","article-title":"Salicylate-induced rhabdomyolysis","volume":"7","author":"LJ Leventhal","year":"1989","journal-title":"Am J Emerg Med"},{"issue":"5","key":"pone.0248242.ref005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0735-6757(94)90271-2","article-title":"Salicylate intoxication causing a severe systemic inflammatory response and rhabdomyolysis","volume":"12","author":"H Montgomery","year":"1994","journal-title":"Am J Emerg Med"},{"issue":"4","key":"pone.0248242.ref006","doi-asserted-by":"crossref","first-page":"303","DOI":"10.32098\/mltj.04.2013.11","article-title":"Rhabdomyolysis. The role of diagnostic and prognostic factors","volume":"3","author":"E Keltz","year":"2013","journal-title":"Muscles Ligaments Tendons J."},{"issue":"6","key":"pone.0248242.ref007","article-title":"Circulatory Failure among Hospitalizations for Heatstroke in the United States","volume":"7","author":"T Bathini","year":"2020","journal-title":"Medicines (Basel)"},{"key":"pone.0248242.ref008","first-page":"e13745","article-title":"Acute kidney injury among salicylate intoxication hospitalisations in the United States","volume":"2020","author":"C Thongprayoon","journal-title":"Int J Clin Pract"},{"issue":"16","key":"pone.0248242.ref009","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"GS Martin","year":"2003","journal-title":"N Engl J Med"},{"issue":"1","key":"pone.0248242.ref010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2165\/00002512-199202010-00004","article-title":"Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it","volume":"2","author":"C Durnas","year":"1992","journal-title":"Drugs Aging."},{"issue":"9","key":"pone.0248242.ref011","doi-asserted-by":"crossref","first-page":"e7182","DOI":"10.1371\/journal.pone.0007182","article-title":"Rhabdomyolysis in community acquired bacterial sepsis\u2014a retrospective cohort study","volume":"4","author":"AA Kumar","year":"2009","journal-title":"PLoS One"},{"issue":"5","key":"pone.0248242.ref012","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s001340050882","article-title":"Bacterial sepsis-induced rhabdomyolysis","volume":"25","author":"A Betrosian","year":"1999","journal-title":"Intensive Care Med"},{"key":"pone.0248242.ref013","article-title":"Impact of Rhabdomyolysis on outcomes of hospitalizations for heat stroke in the United States","author":"C Thongprayoon","year":"2020","journal-title":"Hosp Pract (1995)"},{"issue":"1","key":"pone.0248242.ref014","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13054-016-1314-5","article-title":"Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice","volume":"20","author":"LO Chavez","year":"2016","journal-title":"Crit Care"},{"issue":"2","key":"pone.0248242.ref015","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/jnnp.51.2.301","article-title":"Race-gender differences in serum creatine kinase activity: a study among South Africans","volume":"51","author":"RF Gledhill","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"pone.0248242.ref016","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ajcp\/79.5.582","article-title":"Heterogeneity of serum creatine kinase activity among racial and gender groups of the population","volume":"79","author":"ET Wong","year":"1983","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"pone.0248242.ref017","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra0801327","article-title":"Rhabdomyolysis and acute kidney injury","volume":"361","author":"X Bosch","year":"2009","journal-title":"N Engl J Med"},{"issue":"10","key":"pone.0248242.ref018","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3748\/wjg.v26.i10.1020","article-title":"Abnormal liver function tests associated with severe rhabdomyolysis","volume":"26","author":"AK Lim","year":"2020","journal-title":"World J Gastroenterol"},{"issue":"12","key":"pone.0248242.ref019","first-page":"1385","article-title":"Clinical implications of salicylate-induced liver damage","volume":"129","author":"G Levy","year":"1975","journal-title":"Am J Dis Child"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T18:27:07Z","timestamp":1615228027000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248242"}},"subtitle":[],"editor":[{"given":"Laura","family":"Pasin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0248242","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2021,3,8]]}}}