{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:55:27Z","timestamp":1781175327913,"version":"3.54.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303355\/2018-2"],"award-info":[{"award-number":["303355\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308383\/2018-4"],"award-info":[{"award-number":["308383\/2018-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["88881.166839\/2018-01"],"award-info":[{"award-number":["88881.166839\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>We aimed at evaluating the anti-asthmatic effect of <jats:italic>cis<\/jats:italic>-[Ru(bpy)<jats:sub>2<\/jats:sub>(2-MIM)(NO)](PF<jats:sub>6<\/jats:sub>)<jats:sub>3<\/jats:sub> (FOR811A), a nitrosyl-ruthenium compound, in a murine model of allergic asthma. The anti-asthmatic effects were analyzed by measuring the mechanical lung and morphometrical parameters in female Swiss mice allocated in the following groups: untreated control (Ctl+Sal) and control treated with FOR811A (Ctl+FOR), along asthmatic groups untreated (Ast+Sal) and treated with FOR811A (Ast+FOR). The drug-protein interaction was evaluated by <jats:italic>in-silico<\/jats:italic> assay using molecular docking. The results showed that the use of FOR811A in experimental asthma (Ast+FOR) decreased the pressure-volume curve, hysteresis, tissue elastance, tissue resistance, and airway resistance, similar to the control groups (Ctl+Sal; Ctl+FOR). However, it differed from the untreated asthmatic group (Ast+Sal, <jats:italic>p<\/jats:italic>&lt;0.05), indicating that FOR811A corrected the lung parenchyma and relaxed the smooth muscles of the bronchi. Similar to control groups (Ctl+Sal; Ctl+FOR), FOR811A increased the inspiratory capacity and static compliance in asthmatic animals (Ast+Sal, <jats:italic>p<\/jats:italic>&lt;0.05), showing that this metallodrug improved the capacity of inspiration during asthma. The morphometric parameters showed that FOR811A decreased the alveolar collapse and kept the bronchoconstriction during asthma. Beyond that, the molecular docking using FOR811A showed a strong interaction in the distal portion of the heme group of the soluble guanylate cyclase, particularly with cysteine residue (Cys141). In summary, FOR811A relaxed bronchial smooth muscles and improved respiratory mechanics during asthma, providing a protective effect and promising use for the development of an anti-asthmatic drug.<\/jats:p>","DOI":"10.1371\/journal.pone.0248394","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T18:35:32Z","timestamp":1615574132000},"page":"e0248394","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice"],"prefix":"10.1371","volume":"16","author":[{"given":"Paula Priscila Correia","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6719-1794","authenticated-orcid":true,"given":"Stefanie Bressan","family":"Waller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvan Ribeiro","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fladimir de Lima","family":"Gondim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Silveira","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Sales \u00c1vila","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor\u00eancio Sousa","family":"Gouveia J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-7194","authenticated-orcid":true,"given":"Valdir Ferreira","family":"de Paula J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-8452","authenticated-orcid":true,"given":"Eduardo Henrique Silva","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gonzaga de Fran\u00e7a","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-0013","authenticated-orcid":true,"given":"Wesley Lyeverton Correia","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Serra Azul","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"pone.0248394.ref001","first-page":"nuaa005","article-title":"The role of nutrition in asthma prevention and treatment.","author":"J Alwarith","year":"2020","journal-title":"Nutr Rev"},{"key":"pone.0248394.ref002","doi-asserted-by":"crossref","first-page":"180111","DOI":"10.1183\/16000617.0111-2018","article-title":"Dismantling the pathophysiology of asthma using imaging.","volume":"28","author":"GG King","year":"2019","journal-title":"Eur Respir Rev"},{"issue":"2","key":"pone.0248394.ref003","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"125","author":"KD Stone","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"pone.0248394.ref004","first-page":"1","article-title":"National surveillance of asthma: United States, 2001\u20132010.","volume":"35","author":"JE Moorman","year":"2012","journal-title":"Vital Health Stat"},{"key":"pone.0248394.ref005","first-page":"1","article-title":"Trends in asthma prevalence, health care use, and mortality in the United States, 2001\u20132010.","volume":"94","author":"LJ Akinbami","year":"2012","journal-title":"NCHS Data Brief"},{"key":"pone.0248394.ref006","unstructured":"Global Initiative for Asthma. 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