{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T14:30:41Z","timestamp":1770561041999,"version":"3.49.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970497"],"award-info":[{"award-number":["81970497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background &amp; aims<\/jats:title><jats:p><jats:italic>Helicobacter pylori (H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>) infection remains high in China though the incidence of inflammatory bowel disease (IBD) has increased. Our aim was to investigate the relationship between the prevalence of<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>and inflammatory bowel disease.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Hospitalized IBD patients including Crohn\u2019s disease (CD) and ulcerative colitis (UC) who had tested<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>antibody were enrolled. Controls were chose from age- and sex- matched healthy physical examination people who had<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>antibody test in a 1:2 fashion (IBD patients:controls). IBD medical history was recorded. All patients were typed by the Montreal classification. Mayo Clinic score and the Harvey-Bradshaw Severity Index were used to evaluate their disease activity. Patients and controls that had<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>eradication therapy before were excluded.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Two hundred and sixty IBD patients including 213 CD patients and 47 UC patients, and 520 controls were involved in this study. The prevalence of<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection in IBD patients (9.6%, 25\/260) and IBD newly diagnosed patients (12.1%, 8\/66), as well as CD patients (8.9%, 19\/213) including CD newly diagnosed patients (10.6%, 5\/47) and UC patients (12.8%, 6\/47) was significantly lower than controls (29.8%, 155\/520) (<jats:italic>p<\/jats:italic>= 2.796*10<jats:sup>\u221210<\/jats:sup>, 0.007, 5.723*10<jats:sup>\u22129<\/jats:sup>, 0.016, 0.014), while there was no statistically difference between UC newly diagnosed patients and the controls, and IBD patients with different disease type, disease activity and treatment history.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection had a negative association with IBD, especially CD.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0248427","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T18:24:31Z","timestamp":1615573471000},"page":"e0248427","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control 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