{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:22Z","timestamp":1787022082158,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>As US Hispanic populations are at higher risk than non-Hispanics for cardiovascular disease and Type 2 diabetes targeted interventions are clearly needed. This paper presents the four years results of the Vida Sana Program (VSP), which was developed and is implemented by a small clinic serving mostly Spanish-speaking, limited literacy population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The eight-week course of interactive two-hour sessions taught by\n                      <jats:italic>Navegantes<\/jats:italic>\n                      , bilingual\/cultural community health workers, was delivered to participants with hypertension, or high lipids, BMI, waist circumference, glucose or hemoglobin A1C (A1C). Measures, collected by\n                      <jats:italic>Navegantes<\/jats:italic>\n                      and clinic nurses, included blood chemistries, blood pressure, anthropometry, and an assessment of healthy food knowledge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most participants (67%) were female, Hispanic (95%), and all were 18 to 70 years of age. At baseline, close to half of participants were obese (48%), had high waist circumference (53%), or elevated A1C (52%), or fasting blood glucose (57%). About one third had high blood pressure (29%) or serum cholesterol (35%), and 22% scored low on the knowledge assessment. After the intervention, participants decreased in weight (-1.0 lb), BMI (-0.2 kg\/m2), WC (-0.4 inches), and cholesterol (-3.5 mg\/dl, all p&lt;0.001). Systolic blood pressure decreased (-1.7 mm Hg, p&lt;0.001), and the knowledge score increased (6.8 percent, p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>VSP shows promising improvements in metabolic outcomes, similar to other programs with longer duration or higher intensity interventions. VSP demonstrates an important model for successful community-connected interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0248473","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T14:26:04Z","timestamp":1617287164000},"page":"e0248473","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical outcomes of a community clinic-based lifestyle change program for prevention and management of metabolic syndrome: Results of the \u2018Vida Sana\/Healthy Life\u2019 program"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-1931","authenticated-orcid":true,"given":"Patricia Markham","family":"Risica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan 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D. X. 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Diabetes.","volume":"4","author":"J Reyes","year":"2017","journal-title":"Global qualitative nursing research"},{"key":"pone.0248473.ref022","article-title":"The 24-month metabolic benefits of the healthy living partnerships to prevent diabetes: A community-based translational study","author":"CF Pedley","year":"2017","journal-title":"Diabetes Metab Syndr"},{"issue":"4","key":"pone.0248473.ref023","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2337\/dc10-1981","article-title":"Randomized trial of a literacy-sensitive, culturally tailored diabetes self-management intervention for low-income latinos: latinos en control","volume":"34","author":"MC Rosal","year":"2011","journal-title":"Diabetes Care"},{"issue":"6","key":"pone.0248473.ref024","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/cts.12114","article-title":"The design and conduct of a community-based registry and biorepository: a focus on cardiometabolic health in Latinos.","volume":"6","author":"GQ Shaibi","year":"2013","journal-title":"Clinical and translational science"},{"issue":"3","key":"pone.0248473.ref025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.18865\/ed.26.3.339","article-title":"Hypertension Prevalence in New York City Adults: Unmasking Undetected Racial\/Ethnic Variation, NYC HANES 2004","volume":"26","author":"AE Giambrone","year":"2016","journal-title":"Ethn Dis"},{"issue":"6","key":"pone.0248473.ref026","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"WC Knowler","year":"2002","journal-title":"The New England journal of medicine"},{"issue":"2","key":"pone.0248473.ref027","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2105\/AJPH.2011.300357","article-title":"Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project","volume":"102","author":"IS Ockene","year":"2012","journal-title":"Am J Public Health"},{"issue":"4","key":"pone.0248473.ref028","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jand.2014.10.020","article-title":"The effectiveness of two community-based weight loss strategies among obese, low-income US Latinos.","volume":"115","author":"LG Rosas","year":"2015","journal-title":"J Acad Nutr Diet"},{"key":"pone.0248473.ref029","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cct.2016.03.003","article-title":"Evaluation of a culturally-adapted lifestyle intervention to treat elevated cardiometabolic risk of Latino adults in primary care (Vida Sana): A randomized controlled trial","volume":"48","author":"LG Rosas","year":"2016","journal-title":"Contemporary clinical trials"},{"issue":"4","key":"pone.0248473.ref030","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1089\/jwh.2013.4570","article-title":"Community-based cardiovascular disease 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One"},{"issue":"1","key":"pone.0248473.ref033","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11906-020-01121-6","article-title":"Implementing Hypertension Management Interventions in Immigrant Communities in the U.S.: a Narrative Review of Recent Developments and Suggestions for Programmatic Efforts.","volume":"23","author":"SH Ali","year":"2021","journal-title":"Current hypertension reports"},{"issue":"8","key":"pone.0248473.ref034","doi-asserted-by":"crossref","first-page":"611","DOI":"10.7326\/0003-4819-142-8-200504190-00009","article-title":"The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial","volume":"142","author":"TJ Orchard","year":"2005","journal-title":"Annals of internal medicine"},{"issue":"4","key":"pone.0248473.ref035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4037\/ajcc2007.16.4.336","article-title":"Comparison of point-of-care and laboratory glucose 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