{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:08:35Z","timestamp":1787166515930,"version":"build-2736575974"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We previously reported that macular pigment optical density (MPOD) levels decreased during a long follow-up period after clear intraocular lens (IOL) implant surgery presumably due to excessive light exposure. We examined changes in MPOD levels in the eyes that received yellow-tinted IOL implant surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>This was a prospective, observational study. Fifty-five eyes of 35 patients were studied. MPOD levels were measured with a dual-wavelength autofluorescence technique on day 4; months 1, 3, and 6; and years 1 and 2 postoperatively. The average optical densities at 0\u00b0- 2\u00b0 eccentricities (local MPODs) and total volumes of MPOD (MPOVs) in the area within 1.5\u00b0 and 9\u00b0 eccentricities were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean local MPOD at baseline (on day 4) was 0.79 at 0\u00b0, 0.71 at 0.5\u00b0, 0.68 at 0.9\u00b0, and 0.32 at 2\u00b0. The mean MPOV within 1.5\u00b0 and 9\u00b0 at baseline was 2950 and 18,897, respectively. Local MPOD at 0.9\u00b0 and 2\u00b0 and MPOVs were slightly decreased at month 1 and increased after that. The increase reached statistical significance in local MPOD at 0.5\u00b0 and 2\u00b0 and MPOVs (Tukey\u2013Kramer test). The changes in MPOV within 9\u00b0 at year 2 [(MPOV on year 2 \u2212 MPOV on day 4) \/ MPOV on day 4] were from \u22120.21 to 1.18 (mean and standard deviation: 1.14 \u00b1 0.28). The MPOV of 15 eyes increased more than 10% from the initial value, was maintained within 10% in 21 eyes, and deteriorated more than 10% in only 3 eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Local MPOD and MPOV tended to slightly decrease month 1 postoperatively and gradually increased after that, but the rates of increases in MPOD levels were small. Yellow-tinted IOLs that have a lower transmittance of blue light might be preferable for preserving MPOD levels after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0248506","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T16:15:50Z","timestamp":1616688950000},"page":"e0248506","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Macular pigment changes after cataract surgery with yellow-tinted intraocular lens 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