{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:13:11Z","timestamp":1790266391836,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2016YFC1000500"],"award-info":[{"award-number":["2016YFC1000500"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Several recent studies demonstrated that lung ultrasound could achieve desired diagnostic accuracy for transient tachypnea of the neonate (TTN). However, the diagnostic performance of lung ultrasound for TTN has not been systematically studied to date. This meta-analysis aimed to investigate the performance of lung ultrasound in diagnosing TTN. The relevant literature was searched in PubMed, Medline, the Cochrane Library, and Embase databases without any restriction in terms of language and time until January 31, 2021. Studies that assessed the diagnostic performance of lung ultrasound for TTN were included. Seven studies with 1514 participants were summarized. The lung ultrasound provided more accurate performance for diagnosing TTN with pooled sensitivity and specificity of 0.67 [95% confidence interval (CI) = 0.63\u20130.71] and 0.97 (95% CI = 0.95\u20130.98), respectively. A higher summarized area under the summary receiver operating characteristic curve was observed as 0.9906. Lower sensitivity and area under the curve (AUC) of B-lines for TTN were observed as 0.330 (95% CI = 0.27\u20130.38) and 0.5000, respectively. Lung ultrasound provided highly accurate AUC, sensitivity, and specificity in detecting TTN. Large-scale studies are warranted in the future to confirm these results.<\/jats:p>","DOI":"10.1371\/journal.pone.0248827","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T17:25:47Z","timestamp":1617038747000},"page":"e0248827","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Diagnostic performance of lung ultrasound for transient tachypnea of the newborn: A meta-analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Lili","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-2158","authenticated-orcid":true,"given":"Qiong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"pone.0248827.ref001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1001\/archpedi.1966.02090070078010","article-title":"Transient tachypnea of newborn. Possible delayed resorption of fluid at birth","volume":"111","author":"ME Avery","year":"1966","journal-title":"Am J Dis Child"},{"key":"pone.0248827.ref002","doi-asserted-by":"crossref","first-page":"e106051","DOI":"10.1371\/journal.pone.0106051","article-title":"Accuracy of the interpretation of chest radiographs for the diagnosis of paediatric pneumonia","volume":"9","author":"MA Elemraid","year":"2014","journal-title":"PLoS One"},{"key":"pone.0248827.ref003","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/157339612802139389","article-title":"Lung Ultrasound in the Critically Ill Neonate","volume":"8","author":"DA Lichtenstein","year":"2012","journal-title":"Curr Pediatr Rev"},{"key":"pone.0248827.ref004","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/bmb\/ldy041","article-title":"Chest ultrasound for the diagnosis of paediatric pulmonary diseases: a systematic review and meta-analysis of diagnostic test accuracy","volume":"129","author":"CC Heuvelings","year":"2019","journal-title":"Br Med Bull"},{"key":"pone.0248827.ref005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3233\/NPM-181796","article-title":"Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress","volume":"11","author":"M Ibrahim","year":"2018","journal-title":"J Neonatal Perinatal Med"},{"key":"pone.0248827.ref006","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1891\/0730-0832.37.4.224","article-title":"Lung Ultrasound as a New Technique for Diagnosis of Neonatal Respiratory Diseases","volume":"37","author":"YN Elsayed","year":"2018","journal-title":"Neonatal Netw"},{"key":"pone.0248827.ref007","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/14767058.2017.1376317","article-title":"Role of chest ultrasound in neonatal lung disease: a review of current evidences","volume":"32","author":"D Sharma","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"pone.0248827.ref008","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000358227","article-title":"Lung ultrasound accuracy in respiratory distress syndrome and transient tachypnea of the newborn","volume":"106","author":"M Vergine","year":"2014","journal-title":"Neonatology"},{"key":"pone.0248827.ref009","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"pone.0248827.ref010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2288-6-9","article-title":"Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies","volume":"6","author":"PF Whiting","year":"2006","journal-title":"BMC Med Res Methodol"},{"key":"pone.0248827.ref011","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"Bmj"},{"key":"pone.0248827.ref012","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"CB Begg","year":"1994","journal-title":"Biometrics"},{"key":"pone.0248827.ref013","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"Bmj"},{"key":"pone.0248827.ref014","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000097454","article-title":"The \u2019double lung point\u2019: an ultrasound sign diagnostic of transient tachypnea of the newborn","volume":"91","author":"R Copetti","year":"2007","journal-title":"Neonatology"},{"key":"pone.0248827.ref015","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1097\/MD.0000000000000197","article-title":"Diagnosis of neonatal transient tachypnea and its differentiation from respiratory distress syndrome using lung ultrasound","volume":"93","author":"J Liu","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"pone.0248827.ref016","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.chest.2015.12.024","article-title":"Lung Ultrasonography to Diagnose Transient Tachypnea of the Newborn","volume":"149","author":"J Liu","year":"2016","journal-title":"Chest"},{"key":"pone.0248827.ref017","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12098-016-2288-7","article-title":"Diagnostic Performance of Point of Care Ultrasonography in Identifying the Etiology of Respiratory Distress in Neonates","volume":"84","author":"H Rachuri","year":"2017","journal-title":"Indian J Pediatr"},{"key":"pone.0248827.ref018","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.arcped.2019.09.009","article-title":"Thoracic ultrasound accuracy for the investigation of initial neonatal respiratory distress","volume":"26","author":"C Grimaldi","year":"2019","journal-title":"Arch Pediatr"},{"issue":"8","key":"pone.0248827.ref019","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.arcped.2019.09.009","article-title":"Thoracic ultrasound accuracy for the investigation of initial neonatal respiratory distress","volume":"26","author":"C Grimaldi","year":"2019","journal-title":"Arch Pediatr"},{"key":"pone.0248827.ref020","doi-asserted-by":"crossref","first-page":"e4635","DOI":"10.1371\/journal.pone.0004635","article-title":"Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants","volume":"4","author":"P Latzin","year":"2009","journal-title":"PLoS One"},{"key":"pone.0248827.ref021","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpeds.2019.06.061","article-title":"Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants","volume":"214","author":"MT Caserta","year":"2019","journal-title":"J Pediatr"},{"key":"pone.0248827.ref022","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00134-012-2513-4","article-title":"International evidence-based recommendations for point-of-care lung ultrasound","volume":"38","author":"G Volpicelli","year":"2012","journal-title":"Intensive Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T17:26:15Z","timestamp":1617038775000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248827"}},"subtitle":[],"editor":[{"given":"Ahmed","family":"Negida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0248827","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]}}}