{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:19Z","timestamp":1793272759714,"version":"4.5.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hemophilic arthropathy, a condition manifested as joint destruction due to spontaneous joint bleeding, is one complication of hemophiliac patients. Early detection and intervention may improve the outcome, in which ultrasonography can be an ideal modality with the introduction of HEAD-US (Hemophilia Early Arthropathy Detection with Ultrasound) protocol. Studies have shown US benefit in hemophiliac patients, including its potential as an alternative for the Hemophiliac Joint Health Score (HJHS) system. However, many of the studies were conducted in countries with better management of hemophilia using prophylaxis treatment. It is unclear whether HEAD-US has a correlation with HJHS in countries using episodic treatment only, like in Indonesia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>This study aimed to explore the correlation between HEAD-US and HJHS in hemophiliac patients with joint problems in Indonesia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>A cross-sectional correlation study between HEAD-US and HJHS was performed with primary data collected from 120 hemophilic patients. US examination was performed on elbow, knee and ankle joints using the HEAD-US scoring method by a musculoskeletal radiologist. HJHS examination was conducted by a trained physiotherapist and a medical rehabilitation specialist. All examiner is member of multidisciplinary Hemophiliac Management Team in Cipto Mangunkusumo General Hospital in Jakarta, Indonesia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age of the participant was 9.3 (5\u201314) years old. The median score of HEAD-US was 8 (1\u201328) with most of the joint abnormalities found on the ankles. The median score of HJHS was 3 (0\u201335), with most joint abnormalities found on the knees. There was a moderate correlation between HEAD-US and HJHS score (p &lt; 0.05, r = 0.65).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>HEAD-US shows a moderate correlation to HJHS in hemophiliac patients who received episodic treatment. HEAD-US can provide additional value in the anatomical evaluation of the joint and could be complementary to HJHS in assessing the joint status in hemophilic patient<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0248952","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T17:29:33Z","timestamp":1617816573000},"page":"e0248952","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Correlation between Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score and Hemophilia Joint Health Score (HJHS) in patients with hemophilic arthropathy"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-3871","authenticated-orcid":true,"given":"Marcel","family":"Prasetyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Moniqa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tulaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joedo","family":"Prihartono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanus Imanuel","family":"Setiawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"issue":"Suppl.4","key":"pone.0248952.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2516.2007.01552.x","article-title":"Optimizing outcomes for patients with severe haemophilia A","volume":"13","author":"SW Pipe","year":"2007","journal-title":"Haemophilia"},{"issue":"Suppl 3","key":"pone.0248952.ref002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2516.2006.01268.x","article-title":"Pathogenesis of haemophilic arthropathy","volume":"12","author":"G Roosendaal","year":"2006","journal-title":"Haemophilia"},{"issue":"9371","key":"pone.0248952.ref003","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","volume":"361","author":"PHB Bolton-Maggs","year":"2003","journal-title":"Haemophilias A and B. The Lancet"},{"issue":"5","key":"pone.0248952.ref004","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2141.2008.07386.x","article-title":"Understanding haemophilic arthropathy: an exploration of current open issues","volume":"143","author":"NWD Jansen","year":"2008","journal-title":"British Journal of Haematology"},{"issue":"1","key":"pone.0248952.ref005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11420-009-9140-9","article-title":"Musculoskeletal complications of hemophilia","volume":"6","author":"EC Rodriguez-Merchan","year":"2010","journal-title":"HSSJ"},{"issue":"3","key":"pone.0248952.ref006","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1365-2516.2001.00509.x","article-title":"Correlation between clinical, radiological and ultrasonograohical image of knee joints in children with haemophilia","volume":"7","author":"A Klukowska","year":"2001","journal-title":"Haemophilia"},{"issue":"12","key":"pone.0248952.ref007","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1111\/j.1538-7836.2008.03160.x","article-title":"Power Doppler sonography in the diagnosis of hemophilic synovitis\u2013a promising tool","volume":"6","author":"SS Acharya","year":"2008","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"1","key":"pone.0248952.ref008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-2516.2010.02380.x","article-title":"Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score","volume":"17","author":"D Melchiorre","year":"2011","journal-title":"Haemophilia"},{"issue":"Suppl 5","key":"pone.0248952.ref009","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2516.2010.02307.x","article-title":"State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future","volume":"16","author":"AS Doria","year":"2010","journal-title":"Haemophilia"},{"key":"pone.0248952.ref010","article-title":"Ultrasonography of joints and correlation with function in haemophilic arthropathy\u2013interim results of a clinical pilot trial (HamarthroSonoPilot)","author":"M Sigl-Kraetzig","year":"2015","journal-title":"Presented at ECR 2015. European Congress of Radiology"},{"issue":"Suppl. 78","key":"pone.0248952.ref011","first-page":"1","article-title":"Imaging techniques for the evaluation of haemophilic arthropathy: a focus on ultrasound","volume":"95","author":"MND Di Minno","year":"2015","journal-title":"European Journal of Haematology"},{"issue":"6","key":"pone.0248952.ref012","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1160\/TH12-11-0874","article-title":"Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)","volume":"109","author":"C Martinoli","year":"2013","journal-title":"Thrombosis and Haemostasis"},{"issue":"1","key":"pone.0248952.ref013","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/hae.12769","article-title":"Value of routine ultrasound in detecting early joint changes in children with haemopilia using the \u201cHaemophilia Early Arthropathy Detection with Ultrasound\u201d protocol","volume":"22","author":"W Foppen","year":"2016","journal-title":"Haemophilia"},{"key":"pone.0248952.ref014","doi-asserted-by":"crossref","first-page":"47","DOI":"10.13181\/mji.v26i1.1494","article-title":"Clinical and ultrasound joint outcomes in severe hemophilia A children receiving episodic treatment in Indonesian National Hemophilia Treatment Center","volume":"26","author":"TT Sari","year":"2017","journal-title":"Med J Indones"},{"key":"pone.0248952.ref015","first-page":"1","article-title":"Comparison of the efficacy and safety of 12\u2010month low\u2010dose factor VIII tertiary prophylaxis vs on\u2010demand treatment in severe haemophilia A children","volume":"00","author":"NA Chozie","year":"2019","journal-title":"Haemophilia"},{"issue":"3","key":"pone.0248952.ref016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User\u2019s guide to correlation coefficients","volume":"18","author":"H Akoglu","year":"2018","journal-title":"Turk J Emerg Med"},{"issue":"13","key":"pone.0248952.ref017","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1182\/blood-2015-01-528414","article-title":"Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens","volume":"125","author":"J Oldenburg","year":"2015","journal-title":"Blood"},{"issue":"2","key":"pone.0248952.ref018","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/hae.12792","article-title":"Early prophylaxis in children with severe haemophilia A: clinical and ultrasound imaging outcomes","volume":"22","author":"C Altisent","year":"2016","journal-title":"Haemophilia"},{"issue":"1","key":"pone.0248952.ref019","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1111\/hae.12268","article-title":"Comparison of ultrasound and magnetic resonance imaging for diagnosis and follow-up of joint lesions in patients with haemophilia","volume":"20","author":"CS Aisa","year":"2014","journal-title":"Haemophilia"},{"key":"pone.0248952.ref020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.15256\/joc.2011.1.2","article-title":"Haemophilia and joint disease: pathophysiology, evaluation, and management","volume":"1","author":"K Knobe","year":"2011","journal-title":"J Comorb"},{"issue":"2","key":"pone.0248952.ref021","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1111\/hae.13147","article-title":"Comparing findings of routine Haemophilia Joint Health Score and Haemophlia Early Arthropathy Detection with UltraSound assessments in adults with haemophilia","volume":"23","author":"MA Timmer","year":"2017","journal-title":"Haemophilia"},{"issue":"2","key":"pone.0248952.ref022","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/hae.12290","article-title":"Haemophilia Joint Health Score in healthy adults playing sports","volume":"209","author":"D Sluiter","year":"2014","journal-title":"Haemophilia"},{"issue":"6","key":"pone.0248952.ref023","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MBC.0000000000000934","article-title":"HJHS 2.1 and HEAD-US assessment in the hemophilic joints: How do their findings compare?","volume":"31","author":"H De la Corte-Rodriguez","year":"2020","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T17:29:52Z","timestamp":1617816592000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0248952"}},"subtitle":[],"editor":[{"given":"Elizabeth S.","family":"Mayne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0248952","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]}}}