{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:35:07Z","timestamp":1783539307901,"version":"3.55.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Blood transfusion saves many people every year that would otherwise have died. The present study aimed to provide an update and insightful information regarding prevalence of the common Transfusion-Transmitted Infections (TTIs) and associated factors among blood donors in Tanzania.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>This was a cross-sectional study involving retrospectively collected data of blood donors from the Tanzania Northern Zone Blood Transfusion Center between 2017 and 2019. Descriptive statistics were performed to describe characteristics of the blood donors. Univariable and multivariable logistic regression analyses were performed to determine association between prevalence of TTIs and socio-demographic factors. P-value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>A total of 101, 616 blood donors were included in the present study of which 85,053(83.7%) were males while 16,563 (16.3%) were females. Of all participants, the majority 45,400 (44.7%) were aged between 18 and 25 years; 79,582 (78.3%) were voluntary non-remunerated donors while 22,034 (21.7%) were replacement donors. The vast majority of them 99,626 (98%) were first time blood donors while 1990 (2%) were multiple donors. The overall prevalence of TTIs was 10.1% (10,226 out of 101,616) of which the leading was HBV accounting for 5.1% (5,264 out of 101,616). Being a replacement donor was associated with all the four types of TTIs: HIV (AOR = 1.22, 95% CI = 1.10\u20131.35), HBV (AOR = 1.35, 95% CI = 1.27\u20131.44), HCV (AOR = 1.28, 95% CI = 1.12\u20131.46), and syphilis (AOR = 1.33, 95% CI = 1.20\u20131.48).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>Our study has demonstrated that Tanzania has relatively high prevalence of TTIs compared to some countries in Sub-Saharan Africa. HBV infection seems to be the most common infection among blood donors and replacement blood donors are at a higher risk of harboring the commonest TTIs among blood donors.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0249061","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T17:37:38Z","timestamp":1616607458000},"page":"e0249061","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Transfusion-Transmitted Infections and associated risk factors at the Northern Zone Blood Transfusion Center in Tanzania: A study of blood donors between 2017 and 2019"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-0168","authenticated-orcid":true,"given":"Alex","family":"Mremi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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factors of transfusion transmissible infections among blood donors at Regional Blood Transfusion Center Nakuru and Tenwek Mission Hospital, Kenya","volume":"34","author":"G Bartonjo","year":"2019","journal-title":"Pan Afr Med J"},{"key":"pone.0249061.ref010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2458-6-21","article-title":"Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis infections among blood donors at the Muhimbili National Hospital in Dar es Salaam, Tanzania","volume":"6","author":"MI Matee","year":"2006","journal-title":"BMC Public Health"},{"issue":"3","key":"pone.0249061.ref011","doi-asserted-by":"crossref","first-page":"e0151038","DOI":"10.1371\/journal.pone.0151038","article-title":"Risk Factors and Screening for Trypanosoma cruzi Infection of Dutch Blood Donors.","volume":"11","author":"E Slot","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"pone.0249061.ref012","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12288-014-0460-7","article-title":"Risk Factors for Transfusion Transmissible Infections Elicited on Post Donation Counselling in Blood Donors: Need to Strengthen Pre-donation Counselling.","volume":"31","author":"S Sachdev","year":"2015","journal-title":"Indian J Hematol Blood Transfus"},{"key":"pone.0249061.ref013"},{"issue":"10","key":"pone.0249061.ref014","doi-asserted-by":"crossref","first-page":"e0206487","DOI":"10.1371\/journal.pone.0206487","article-title":"Prevalence and causes of blood donor deferrals among clients presenting for blood donation in northern Tanzania","volume":"13","author":"DM Valerian","year":"2018","journal-title":"PLoS 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Bygbjerg","year":"2012","journal-title":"Science"},{"issue":"4","key":"pone.0249061.ref024","first-page":"293","article-title":"Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria","volume":"7","author":"FI Buseri","year":"2009","journal-title":"Blood Transfus"},{"issue":"1","key":"pone.0249061.ref025","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/s12879-018-3376-2","article-title":"Seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania","volume":"18","author":"ER Shao","year":"2018","journal-title":"BMC Infect Dis"},{"issue":"1","key":"pone.0249061.ref026","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12889-020-8294-8","article-title":"High prevalence of human immunodeficiency virus, hepatitis B and C viral infections among people who inject drugs: a potential stumbling block in the control of HIV and viral hepatitis in 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