{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:45:23Z","timestamp":1788259523113,"version":"build-2803163510"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Neurodegenerative diseases are sporadic hereditary conditions characterized by progressive dysfunction of the nervous system. Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic paraplegia is a heterogeneous group of hereditary degenerative diseases involving the disorder of a single gene and is characterized by the progressive retrograde degeneration of fibers in the spinal cord.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine the benefits of vestibular rehabilitation involving virtual reality by comparing pre intervention and post intervention assessments in individuals with hereditary spastic paraplegia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this randomized controlled clinical trial from the Rebec platform RBR-3jmx67 in which allocation concealment was performed and the evaluators be blinded will be included. The participants will include 40 patients diagnosed with hereditary spastic paraplegia. The interventions will include vestibular rehabilitation with virtual reality using the Wii<jats:sup>\u00ae<\/jats:sup> console, Wii-Remote and Wii Balance Board (Nintendo), and the studies will include pre- and post intervention assessments. Group I will include twenty volunteers who performed balance games. Group II will include twenty volunteers who performed balance games and muscle strength games. The games lasted from 30 minutes to an hour, and the sessions were performed twice a week for 10 weeks (total: 20 sessions).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>This study provides a definitive assessment of the effectiveness of a virtual reality vestibular rehabilitation program in halting the progression of hereditary spastic paraplegia, and this treatment can be personalized and affordable.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The study will determine whether a vestibular rehabilitation program with the Nintendo Wii<jats:sup>\u00ae<\/jats:sup> involving virtual reality can reduce the progressive effect of hereditary spastic paraplegia and serve as an alternative treatment option that is accessible and inexpensive.<\/jats:p>\n<jats:p>Rebec platform trial: RBR-3JMX67.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0249095","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T17:57:16Z","timestamp":1617299836000},"page":"e0249095","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-2683","authenticated-orcid":true,"given":"Bianca Simone","family":"Zeigelboim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-1838","authenticated-orcid":true,"given":"Maria Renata","family":"Jos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geslaine Janaina Bueno dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Izabel Rodrigues","family":"Severiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Afonso Ghizoni","family":"Teive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Stechman-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane Sampaio","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Miranda","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-1914","authenticated-orcid":true,"given":"Bianca Lopes","family":"Cavalcante-Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"5","key":"pone.0249095.ref001","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1590\/S0004-282X2011000600007","article-title":"Electronystagmography findings in spinocerebellar ataxia type 3 (SCA3) and type 2 (SCA2)","volume":"69","author":"BS Zeigelboim","year":"2011","journal-title":"Arq Neuropsiquiatr"},{"issue":"supl.1","key":"pone.0249095.ref002","first-page":"113","article-title":"Virtual reality in vestibular syndromes","volume":"67","author":"A Zanoni","year":"2010","journal-title":"Rev. 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Quality of Life Assesment","volume":"28","author":"THE WHOQOL GROUP","year":"1998","journal-title":"PsycholMed"},{"issue":"3 Suppl","key":"pone.0249095.ref023","doi-asserted-by":"crossref","DOI":"10.1590\/S0101-81082009000400007","article-title":"WHOQOL-bref, an instrument for quality of life assessment: a systematic review","volume":"31","author":"AC Kluthcovsky","year":"2009","journal-title":"Rev. Psiquiatr. Rio Gd. Sul"},{"issue":"9","key":"pone.0249095.ref024","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1590\/S0100-879X2004000900017","article-title":"Brazilian version of the Berg balance scale","volume":"37","author":"ST Miyamoto","year":"2004","journal-title":"Braz. 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Otorhinolaryngol"},{"issue":"3","key":"pone.0249095.ref033","first-page":"189","article-title":"Mini Mental State. A practical method for rading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatric Res"},{"issue":"1","key":"pone.0249095.ref034","first-page":"1","article-title":"The Mini-Mental State Examination in an outpatient population: influence of literacy","volume":"52","author":"PHF Bertolucci","year":"1994","journal-title":"Arq. Neuro-psiquiatr"},{"issue":"3 B","key":"pone.0249095.ref035","first-page":"777","article-title":"Suggestions for utilization of the mini-mental state examination in Brazil","volume":"61","author":"SMD Brucki","year":"2003","journal-title":"Arq Neuropsiquiatr"},{"issue":"4","key":"pone.0249095.ref036","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3233\/JAD-131403","article-title":"The new Qualitative Scoring MMSE Pentagon Test (QSPT) as a valid screening tool between autopsy-confirmed dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"39","author":"M Mitolo","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"pone.0249095.ref037","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1212\/WNL.36.2.262","article-title":"A correlational analysis of the Blessed Information-Memory-Concentration Test and the Mini-Mental State Exam","volume":"36","author":"LJ Thal","year":"1986","journal-title":"Neurology"},{"issue":"4","key":"pone.0249095.ref038","first-page":"143","article-title":"Timed up and go test: a comparison between values obtained outdoors and indoors","volume":"20","author":"FL Paula","year":"2007","journal-title":"Fisioter. mov"},{"issue":"2","key":"pone.0249095.ref039","first-page":"68","article-title":"Comparison of the propensity of falls between elderly people who practice physical activity and elderly sedentary","volume":"12","author":"LHCT Guimar\u00e3es","year":"2004","journal-title":"Rev. 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