{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:22:55Z","timestamp":1789611775010,"version":"build-2803163510"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012902","name":"Saint Paul's Hospital Millennium Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aims to assess the magnitude and associated factors of poor medication adherence among diabetic and hypertensive patients visiting public health facilities in Addis Ababa, Ethiopia during the COVID-19 pandemic.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A multi-site cross-sectional design was conducted from 1<jats:sup>st<\/jats:sup> through 30<jats:sup>th<\/jats:sup> of August 2020 at public health facilities of the study area. Adult outpatients with T2DM and hypertension visiting hospitals and health centers were included in the study. A proportion to size allocation method was used to determine the required sample size per facility. Data was collected using the 8-item Morisky medication adherence scale. Descriptive statistics and binary logistic regression were used to analyze data. A 95% confidence interval and p\u22640.05 statistical significance was considered to determine factors associated with poor medication adherence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 409 patients were included in the present study. About 57% of the patients reported that the COVID-19 pandemic has posed negative impacts on either of their follow-up visits, availability of medications, or affordability of prices. And, 21% have reported that they have been affected in all aspects. The overall magnitude of poor medication adherence was 72%. Patients with extreme poverty were more likely to have good medication adherence (AOR: 0.59; 95%C.I: 0.36\u20130.97), whereas attendance to a health center (AOR: 1.71; 95%C.I: 1.02\u20132.85), presence of comorbidity (AOR: 2.05; 95%C.I: 1.13\u20133.71), and current substance use history (AOR: 11.57; 95%C.I: 1.52\u201388.05) predicted high odds of poor adherence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Over a three-fourth of the patients, in the study setting, have poor adherence to their anti-diabetic and antihypertensive medications. Health facility type, income level, comorbidity, and current substance use history showed a statistically significant association with poor adherence to medication. Stakeholders should set alternative strategies as perceived impacts of the COVID-19 pandemic on medication adherence are high in the study area.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0249222","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T17:32:28Z","timestamp":1617730348000},"page":"e0249222","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Magnitude and associated factors of poor medication adherence among diabetic and hypertensive patients visiting public health facilities in Ethiopia during the COVID-19 pandemic"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-7597","authenticated-orcid":true,"given":"Tariku","family":"Shimels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodas","family":"Asrat 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to long-term therapies: policy for action: meeting report, 4\u20135 June 2001","author":"World Health Organization","year":"2001"},{"issue":"4","key":"pone.0249222.ref002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF00846477","article-title":"Determinants of adherence to medical regimens by hypertensive patients","volume":"10","author":"AL Stanton","year":"1987","journal-title":"Journal of Behavioral Medicine"},{"key":"pone.0249222.ref003","doi-asserted-by":"crossref","first-page":"68D","DOI":"10.1016\/0002-9149(93)90014-4","article-title":"Measuring adherence with therapy for chronic diseases: implications for the treatment of heterozygous familial hypercholesterolemia","volume":"72","author":"CS Rand","year":"1993","journal-title":"American Journal of Cardiology"},{"key":"pone.0249222.ref004","first-page":"17","volume-title":"What is adherence","author":"World Health Organization (WHO)","year":"2003"},{"issue":"22","key":"pone.0249222.ref005","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1001\/jama.288.22.2880","article-title":"Helping Patients Follow Prescribed Treatment: Clinical Applications","volume":"288","author":"RB Haynes","year":"2002","journal-title":"JAMA"},{"key":"pone.0249222.ref006","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/bmj.39553.670231.25","article-title":"Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories","volume":"336","author":"B Vrijens","year":"2008","journal-title":"BMJ"},{"issue":"1","key":"pone.0249222.ref007","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.mcna.2016.08.005","article-title":"Adherence to Antihypertensive Therapy","volume":"101","author":"E Peacock","year":"2017","journal-title":"Med Clin North Am"},{"issue":"1","key":"pone.0249222.ref008","first-page":"33","article-title":"Monitoring one-year compliance to antihypertension medication in the Seychelles","volume":"80","author":"P Bovet","year":"2002","journal-title":"Bull World Health Organ"},{"key":"pone.0249222.ref009","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/sj.jhh.1001050","article-title":"Blood pressure patterns and cardiovascular risk factors in rural and urban Gambian communities","volume":"14","author":"MA Van der Sande","year":"2000","journal-title":"Journal of Human Hypertension"},{"issue":"4","key":"pone.0249222.ref010","doi-asserted-by":"crossref","first-page":"e62775","DOI":"10.1371\/journal.pone.0062775","article-title":"Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky Medication Adherence Scale","volume":"8","author":"GK Lee","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"pone.0249222.ref011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13104-018-3139-6","article-title":"Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia","author":"SW Asgedom","year":"2018","journal-title":"BMC Res Notes"},{"key":"pone.0249222.ref012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2048004019892758","article-title":"Determinants of adherence to antihypertensive medications among adult hypertensive patients on follow-up in Hawassa Referral Hospital: A case-control study","volume":"8","author":"A Getenet","year":"2019","journal-title":"JRSM Cardiovascular Disease"},{"issue":"4","key":"pone.0249222.ref013","first-page":"47","article-title":"Adherence to prescribed antihypertensive medications and associated factors for hypertensive patients attending chronic follow-up units of selected public hospitals in Addis Ababa, Ethiopia","volume":"11","author":"A Tibebu","year":"2017","journal-title":"Int J Health Sci (Qassim)"},{"key":"pone.0249222.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IBPC.S128914","article-title":"Medication adherence and its associated factors among hypertensive patients attending the Debre Tabor General Hospital, northwest Ethiopia","volume":"10","author":"DF Teshome","year":"2017","journal-title":"Integr Blood Press Control"},{"key":"pone.0249222.ref015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4172\/2161-1165.1000322","article-title":"Medication Adherence among Type 2 Diabetes Ambulatory Patients in Zewditu Memorial Hospital, Addis Ababa, Ethiopia","volume":"7","author":"Y Mesfin","year":"2017","journal-title":"Epidemiology (Sunnyvale)"},{"key":"pone.0249222.ref016","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1186\/s13104-017-3025-7","article-title":"Medication adherence and its associated factors among diabetic patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia","volume":"10","author":"M Ali","year":"2017","journal-title":"BMC Res Notes"},{"issue":"10","key":"pone.0249222.ref017","doi-asserted-by":"crossref","first-page":"e0222985","DOI":"10.1371\/journal.pone.0222985","article-title":"Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia","volume":"14","author":"GT Demoz","year":"2019","journal-title":"PLoS ONE"},{"issue":"11","key":"pone.0249222.ref018","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/0003-4819-157-11-201212040-00538","article-title":"Interventions to Improve Adherence to Self-administered Medications for Chronic Diseases in the United States: A Systematic Review","volume":"157","author":"M Viswanathan","year":"2012","journal-title":"Ann Intern Med"},{"issue":"1","key":"pone.0249222.ref019","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.sapharm.2020.04.007","article-title":"Medication management 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Addis Ababa, Ethiopia: Enhancing Urban Resilience. Washington DC. 2015. Pages 25\u201330. Available at http:\/\/documents1.worldbank.org\/curated\/en\/559781468196153638\/pdf\/Addis-Ababa-Enhancing-Urban-Resilience-city-strength-resilient-cities-program.pdf. Accessed on 17 March 2021."},{"key":"pone.0249222.ref021","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1186\/1471-2458-12-1007","article-title":"Patterns of mortality in public and private hospitals of Addis Ababa, Ethiopia","volume":"12","author":"A Misganaw","year":"2012","journal-title":"BMC Public Health"},{"key":"pone.0249222.ref022","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/1472-6963-14-431","article-title":"Knowledge and experience sharing practices among health professionals in hospitals under the Addis Ababa health bureau, Ethiopia","volume":"14","author":"MA Asemahagn","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"pone.0249222.ref023","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2147\/DMSO.S237995","article-title":"Prevalence of Diabetes Mellitus and Associated Factors in Addis Ababa Public Health Facilities, Addis Ababa, Ethiopia, 2016","volume":"13","author":"AT Sahile","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"pone.0249222.ref024","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13104-019-4127-1","article-title":"Prevalence of hypertension among adult outpatient clients in hospitals and its associated factors In Addis Ababa, Ethiopia: a hospital-based cross-sectional study","volume":"12","author":"S Abebe","year":"2019","journal-title":"BMC Res Notes"},{"issue":"6","key":"pone.0249222.ref025","doi-asserted-by":"crossref","first-page":"280","DOI":"10.15406\/mojph.2018.07.00252","article-title":"Magnitude and associated factors of hypertension in Addis Ababa public health facilities, Ethiopia","volume":"7","author":"GE Bekele","year":"2018","journal-title":"MOJ Public Health"},{"key":"pone.0249222.ref026","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1751-7176.2008.07572.x","article-title":"Predictive validity of medication adherence measure in an outpatient setting","volume":"10","author":"DE Morisky","year":"2008","journal-title":"J Clin Hypertens"},{"key":"pone.0249222.ref027","doi-asserted-by":"crossref","unstructured":"Casta\u00f1eda A, Doan D, Newhouse D, Nguyen MC, Uematsu H, Azevedo JP. Who Are the Poor in the Developing World? Poverty and Shared Prosperity Report 2016: Taking on Inequality. Policy Research Working Paper 7844. World Bank Group. 2016. Available at: http:\/\/econ.worldbank.org. Accessed on 10 October 2020.","DOI":"10.1596\/1813-9450-7844"},{"key":"pone.0249222.ref028","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12875-020-01326-3","article-title":"The impact of COVID-19 on chronic care according to providers: a qualitative study among primary care practices in Belgium","volume":"21","author":"K Danhieux","year":"2020","journal-title":"BMC Fam Pract"},{"issue":"5","key":"pone.0249222.ref029","first-page":"965","article-title":"Impact of COVID-19 on routine care for chronic diseases: A global survey of views from healthcare professionals, Diabetes & Metabolic Syndrome","volume":"14","author":"YV Chudasama","year":"2020","journal-title":"Clinical Research & Reviews"},{"key":"pone.0249222.ref030","unstructured":"World Health Organization (WHO). COVID-19 significantly impacts health services for non-communicable diseases. Geneva.2020. Available at: https:\/\/www.who.int\/news\/item\/01-06-2020-covid-19-significantly-impacts-health-services-for-noncommunicable-diseases accessed on October 25, 2020."},{"issue":"2","key":"pone.0249222.ref031","first-page":"94","article-title":"Implications of COVID-19 for the management of chronic non-communicable diseases in sub-Saharan Africa: application of the chronic care model","volume":"35","author":"H Amu","year":"2020","journal-title":"Pan African Medical Journal"},{"issue":"2","key":"pone.0249222.ref032","first-page":"66","article-title":"COVID-19 in Ethiopia: current situation, missed opportunities, and the risk of health system disruptions","volume":"35","author":"S Biadgilign","year":"2020","journal-title":"Pan African Medical Journal"},{"issue":"4","key":"pone.0249222.ref033","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4065\/mcp.2010.0575","article-title":"Medication adherence: WHO cares?","volume":"86","author":"MT Brown","year":"2011","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"pone.0249222.ref034","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1547-5069.2003.tb00001.x","article-title":"Adherence to long-term therapies: evidence for action","volume":"35","author":"PV Burkhart","year":"2003","journal-title":"J Nurs Scholarsh"},{"key":"pone.0249222.ref035","doi-asserted-by":"crossref","unstructured":"Mid\u00e3o L, Giardini A, Menditto E, Kardas P and Costa E. Adherence to Medication in Older Adults as a Way to Improve Health Outcomes and Reduce Healthcare System Spending. In: D\u2019Onofrio G, editor. Gerontology. July 4th 2018. DOI: 10.5772\/intechopen.72070. Available from: https:\/\/www.intechopen.com\/books\/gerontology\/adherence-to-medication-in-older-adults-as-a-way-to-improve-health-outcomes-and-reduce-healthcare-sy accessed on 26 October 2020.","DOI":"10.5772\/intechopen.72070"},{"key":"pone.0249222.ref036","article-title":"The Current Mental Health Crisis of COVID-19 Pandemic Among Communities Living in Gedeo Zone Dilla, SNNP, Ethiopia","author":"C Kassaw","year":"2020","journal-title":"J. Psychosoc. Rehabil. Ment. Health"},{"key":"pone.0249222.ref037","volume-title":"Evaluating patient compliance: Effect of appointment reminder systems on attendance","author":"J Phillips","year":"2008"},{"key":"pone.0249222.ref038","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13098-020-00567-7","article-title":"Predictors of poor adherence to antidiabetic therapy in patients with type 2 diabetes: a cross-sectional study insight from Ethiopia","volume":"12","author":"GT Demoz","year":"2020","journal-title":"Diabetol Metab Syndr"},{"key":"pone.0249222.ref039","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2147\/DMSO.S36368","article-title":"Importance of family\/social support and impact on adherence to diabetic therapy","volume":"6","author":"TA Miller","year":"2013","journal-title":"Diabetes Metab Syndr Obes: Targets and Therapy"},{"key":"pone.0249222.ref040","volume-title":"ABC Project Final Report","author":"P Kardas","year":"2012"},{"issue":"3","key":"pone.0249222.ref041","first-page":"189","article-title":"The challenge of patient adherence","volume":"1","author":"LR Martin","year":"2005","journal-title":"Ther Clin Risk Manag"},{"issue":"4","key":"pone.0249222.ref042","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4065\/mcp.2010.0575","article-title":"Medication adherence: WHO cares?","volume":"86","author":"MT Brown","year":"2011","journal-title":"Mayo Clinic Proceedings"},{"key":"pone.0249222.ref043","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1056\/NEJMra050100","article-title":"Adherence to medication","volume":"353","author":"L Osterberg","year":"2005","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"pone.0249222.ref044","first-page":"203","article-title":"Guidance to manage inappropriate polypharmacy in older people: Systematic review and future developments","volume":"16","author":"D Stewart","year":"2017","journal-title":"Expert Opin Drug Saf"},{"issue":"4","key":"pone.0249222.ref045","article-title":"Comparison of medication adherence between type 2 diabetes mellitus patients who pay for their medications and those who receive it free: a rural Asian experience","volume":"38","author":"D Rathish","year":"2019","journal-title":"J Health Popul Nutr"},{"issue":"2","key":"pone.0249222.ref046","article-title":"The Influence of Income on Health: Views of an Epidemiologist","volume":"21","author":"M Marmot","year":"2002","journal-title":"Health Aff(Millwood)"},{"issue":"3","key":"pone.0249222.ref047","doi-asserted-by":"crossref","first-page":"e0120560","DOI":"10.1371\/journal.pone.0120560","article-title":"Factors associated with medication adherence among patients with schizophrenia in Mekelle, Northern Ethiopia","volume":"10","author":"T Eticha","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"pone.0249222.ref048","doi-asserted-by":"crossref","first-page":"e0197482","DOI":"10.1371\/journal.pone.0197482","article-title":"Factors affecting patients\u2019 knowledge about dispensed medicines: A Qualitative study of healthcare professionals and patients in Pakistan","volume":"13","author":"A Saqib","year":"2018","journal-title":"PLoS ONE"},{"issue":"3","key":"pone.0249222.ref049","doi-asserted-by":"crossref","first-page":"e0193995","DOI":"10.1371\/journal.pone.0193995","article-title":"Factors influencing long-term medication non-adherence among diabetes and hypertensive patients in Ghana: A qualitative investigation","volume":"13","author":"RA Atinga","year":"2018","journal-title":"PLoS ONE"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T17:33:20Z","timestamp":1617730400000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249222"}},"subtitle":[],"editor":[{"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0249222","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]}}}