{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:45:40Z","timestamp":1753440340093,"version":"3.40.5"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Data on illicit drug use by Korean people infected with HIV are lacking. Here, we examined the prevalence and patterns of illicit drug use among people infected with HIV in Korea.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Material and methods<\/jats:title>\n<jats:p>In this cross-sectional study, we included all patients infected with HIV who visited a tertiary care hospital in Korea from January 1990 to May 2020. Sociodemographic data of patients, including drug use, were collected at the first visit and during follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among 1,267 patients, 5.13% reported the use of an illicit drug in their lifetime, and 2.61% were users of injection drugs. The most commonly used drugs were cannabis\/marijuana and methamphetamine, followed by nitrite inhalants, cocaine, dextromethorphan, carisoprodol, and 3,4-methylenedioxymethamphetamine. The illicit drug users tended to be younger than non-users, homosexuals\/bisexuals, and infected with hepatitis C virus (HCV); they had a higher CD4<jats:sup>+<\/jats:sup> cell count than non-users. Among 65 users of illicit drugs, only 24.6% revealed their drug use at the first visit interview, and 24.6% reported using two or more drugs in their lifetime. Individuals who used injection drugs were more likely to be arrested for drug-related charges than the users of non-injection drugs. Moreover, they tended to be heavy users of illicit drugs, to report using two or more drugs in their lifetime, and to be HCV seropositive. In contrast, the users of non-injection drugs were more likely to be experimental users and to start using drugs overseas for the first time, but less likely to report their drug use at the first interview.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The prevalence of illicit drug use in people with HIV infection in Korea may have been underestimated. Further research based on more accurate measurements are warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0249361","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T18:21:20Z","timestamp":1617301280000},"page":"e0249361","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and patterns of illicit drug use in people with human immunodeficiency virus infection in Korea"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-2135","authenticated-orcid":true,"given":"Soon Ok","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-3628","authenticated-orcid":true,"given":"Sun Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-5453","authenticated-orcid":true,"given":"Jin Suk","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"9651","key":"pone.0249361.ref001","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0140-6736(08)61311-2","article-title":"Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review","volume":"372","author":"BM Mathers","year":"2008","journal-title":"Lancet"},{"key":"pone.0249361.ref002","unstructured":"Korea SPsoRo. Drug Crime White Paper 2011. http:\/\/www.spo.go.kr\/site\/spo\/ex\/board\/View.do."},{"issue":"11","key":"pone.0249361.ref003","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1177\/0306624X14530671","article-title":"Illicit Drug Use Among South Korean Offenders: Assessing the Generality of Social Learning Theory","volume":"59","author":"M Yun","year":"2015","journal-title":"Int J Offender Ther Comp Criminol"},{"key":"pone.0249361.ref004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12889-016-2731-8","article-title":"Prevalence, correlates, and associated psychological problems of substance use in Korean adolescents","volume":"16","author":"S Park","year":"2016","journal-title":"BMC Public Health"},{"issue":"1","key":"pone.0249361.ref005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13011-016-0078-x","article-title":"Comparison of illegal drug use pattern in Taiwan and Korea from 2006 to 2014","volume":"11","author":"LY Feng","year":"2016","journal-title":"Subst Abuse Treat Prev Policy"},{"key":"pone.0249361.ref006","unstructured":"prevention KCfDCa. 2017 HIV\/AIDS annual report 2018. https:\/\/www.cdc.go.kr\/board\/board.es?mid=a20301070302&bid=0051."},{"key":"pone.0249361.ref007","doi-asserted-by":"crossref","first-page":"e2019037","DOI":"10.4178\/epih.e2019037","article-title":"Epidemiological characteristics of HIV infected Korean: Korea HIV\/AIDS Cohort Study","volume":"41","author":"Y Choi","year":"2019","journal-title":"Epidemiol Health"},{"issue":"4","key":"pone.0249361.ref008","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jmv.23523","article-title":"Prevalence and associated clinical characteristics of hepatitis B, C, and HIV infections among injecting drug users in Korea","volume":"85","author":"JA Min","year":"2013","journal-title":"J Med Virol"},{"issue":"4","key":"pone.0249361.ref009","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3904\/kjim.2015.353","article-title":"Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus (HIV) patients in a large HIV clinic in South Korea","volume":"31","author":"S Lee","year":"2016","journal-title":"Korean J Intern Med"},{"key":"pone.0249361.ref010","unstructured":"Act on the Control of Narcotics 2020. https:\/\/elaw.klri.re.kr\/eng_mobile\/viewer.do?hseq=50166&type=sogan&key=31."},{"issue":"1","key":"pone.0249361.ref011","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/002204268601600103","article-title":"Why do the nation\u2019s students use drugs and alcohol? Self-reported reasons from nine national surveys","volume":"16","author":"LD Johnston","year":"1986","journal-title":"Journal of Drug Issues"},{"issue":"4","key":"pone.0249361.ref012","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jsat.2008.08.005","article-title":"Stress-related factors in cannabis use and misuse: implications for prevention and treatment","volume":"36","author":"SM Hyman","year":"2009","journal-title":"J Subst Abuse Treat"},{"issue":"1","key":"pone.0249361.ref013","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13010030","article-title":"Characterizing the HIV\/AIDS Epidemic in the United States and China","volume":"13","author":"MB Huang","year":"2015","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"pone.0249361.ref014","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11481-016-9665-x","article-title":"Drug Abuse, HIV, and HCV in Asian Countries","volume":"11","author":"YI Hser","year":"2016","journal-title":"J Neuroimmune Pharmacol"},{"issue":"3","key":"pone.0249361.ref015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/QAD.0b013e3282f3cc21","article-title":"Illicit drug use and HIV treatment outcomes in a US cohort","volume":"22","author":"J Cofrancesco","year":"2008","journal-title":"AIDS"},{"key":"pone.0249361.ref016","first-page":"690","article-title":"Recreational drug use among individuals living with HIV in Europe: review of the prevalence, comparison with the general population and HIV guidelines recommendations","volume":"6","author":"N Garin","year":"2015","journal-title":"Front Microbiol"},{"issue":"1","key":"pone.0249361.ref017","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1038\/s41598-018-26413-5","article-title":"Prevalence and Associations of Illicit Drug and Polydrug Use in People Living with HIV in Vienna","volume":"8","author":"I Grabovac","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"pone.0249361.ref018","doi-asserted-by":"crossref","first-page":"e0211252","DOI":"10.1371\/journal.pone.0211252","article-title":"Prevalence and patterns of illicit drug use in people living with HIV in Spain: A cross-sectional study","volume":"14","author":"MJ Fuster-RuizdeApodaca","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"pone.0249361.ref019","doi-asserted-by":"crossref","first-page":"e72310","DOI":"10.1371\/journal.pone.0072310","article-title":"Illicit drug use is a significant risk factor for loss to follow up in patients with HIV-1 infection at a large urban HIV clinic in Tokyo","volume":"8","author":"T Nishijima","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl 2","key":"pone.0249361.ref020","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1097\/01.aids.0000172879.20628.e1","article-title":"Review of sampling hard-to-reach and hidden populations for HIV surveillance","volume":"19","author":"R Magnani","year":"2005","journal-title":"Aids"},{"key":"pone.0249361.ref021","unstructured":"T MKM. Self-reported drug use: how prevalent is under-reporting?. Trends & issues in crime and criminal justice no. 260. Canberra: Australian Institute of Criminology. 2003. https:\/\/aic.gov.au\/publications\/tandi\/tandi260."},{"key":"pone.0249361.ref022","unstructured":"BI C. Drug Control Policy in Korea. International Centre for Criminal Law Reform and Criminal Justice Policy Vancouver2004."},{"issue":"4","key":"pone.0249361.ref023","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s10461-017-2008-y","article-title":"A Study of the Longitudinal Patterns of Stimulant and Amyl Nitrite Use and Sexual Behavior Pre- and Post-HIV Seroconversion Among MSM","volume":"22","author":"JA Swartz","year":"2018","journal-title":"AIDS Behav"},{"issue":"1","key":"pone.0249361.ref024","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1186\/s12889-017-4696-7","article-title":"Knowledge, attitude, and status of nitrite inhalant use among men who have sex with men in Tianjin, China","volume":"17","author":"Z Zhang","year":"2017","journal-title":"BMC Public Health"},{"key":"pone.0249361.ref025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.forsciint.2016.10.024","article-title":"Patterns of drugs & poisons in southern area of South Korea in 2014","volume":"269","author":"E Kim","year":"2016","journal-title":"Forensic Sci Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T18:21:45Z","timestamp":1617301305000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249361"}},"subtitle":[],"editor":[{"given":"Jason T.","family":"Blackard","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0249361","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}