{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:24:57Z","timestamp":1769599497928,"version":"3.49.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The measurement of the electrically evoked compound action potential (ECAP) in cochlear implant (CI) patients is widely used to provide evidence of a functioning electrode-nerve interface, to confirm proper location of the electrode array and to program the sound processor. In patients with an auditory brainstem implant (ABI), a likewise versatile measurement would be desirable. The ECAP measurement paradigm \u201cAlternating Polarity\u201d was utilized to record responses via the implanted ABI electrode array placed on the cochlear nucleus. Emphasizing on the different location of stimulation and recording, these responses are called local evoked potentials (LEP). LEP measurements were conducted during the clinical routine in 16 ABI patients (12 children and 4 adults), corresponding to 191 electrode contacts. A retrospective analysis of these data revealed, that LEP responses were observed in 64.9% of all measured electrode contacts. LEP responses predicted auditory perception with a sensitivity of 90.5%. False-positive rate was 33.7%. Objective LEP thresholds were highly significantly (p &lt; 0.001) correlated both to behavioral thresholds (Pearson\u2019s r = 0.697) and behavioral most comfortable levels (r = 0.840). Therefore, LEP measurements have the potential to support fitting in ABI patients.<\/jats:p>","DOI":"10.1371\/journal.pone.0249535","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T18:21:37Z","timestamp":1617301297000},"page":"e0249535","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Measurements of the local evoked potential from the cochlear nucleus in patients with an auditory brainstem implant and its implication to auditory perception and audio processor programming"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-9487","authenticated-orcid":true,"given":"Lutz","family":"G\u00e4rtner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-3985","authenticated-orcid":true,"given":"Andreas","family":"B\u00fcchner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"1","key":"pone.0249535.ref001","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/019459988409200111","article-title":"Cochlear Nucleus Implant","volume":"92","author":"WE Hitselberger","year":"1984","journal-title":"Otolaryngol Neck Surg"},{"issue":"JAN","key":"pone.0249535.ref002","first-page":"1","article-title":"Auditory brainstem implants: Recent progress and future perspectives","volume":"13","author":"K Wong","year":"2019","journal-title":"Front Neurosci"},{"issue":"4","key":"pone.0249535.ref003","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/MAO.0b013e31828bb75e","article-title":"Speech Comprehension in Children and Adolescents After Sequential Bilateral Cochlear Implantation With Long Interimplant Interval","volume":"34","author":"A Illg","year":"2013","journal-title":"Otol Neurotol"},{"issue":"3","key":"pone.0249535.ref004","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/AUD.0000000000000495","article-title":"Use of Electrically Evoked Compound Action Potentials for Cochlear Implant Fitting: A Systematic Review.","volume":"39","author":"JJ de Vos","year":"2018","journal-title":"Ear Hear"},{"issue":"06","key":"pone.0249535.ref005","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1055\/s-0034-1372590","article-title":"Unerwartet stark abnehmendes Sprachverstehen bei einem Patienten mit Cochlea-Implantat","volume":"93","author":"L G\u00e4rtner","year":"2014","journal-title":"Laryngo-Rhino-Otologie"},{"key":"pone.0249535.ref006","volume-title":"Central Auditory Implants","author":"J Kuchta","year":"2010"},{"issue":"4","key":"pone.0249535.ref007","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3766\/jaaa.16.4.3","article-title":"Neural response telemetry and auditory\/nonauditory sensations in 15 recipients of auditory brainstem implants","volume":"16","author":"SR Otto","year":"2005","journal-title":"J Am Acad Audiol"},{"issue":"6","key":"pone.0249535.ref008","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.anorl.2017.10.005","article-title":"Novel method of fitting of children with auditory brainstem implants","volume":"135","author":"M Polak","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"6","key":"pone.0249535.ref009","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1177\/0194599814551151","article-title":"Improved Outcomes in Auditory Brainstem Implantation with the Use of Near-Field Electrical Compound Action Potentials","volume":"151","author":"M Mandal\u00e0","year":"2014","journal-title":"Otolaryngol Neck Surg"},{"issue":"JUN","key":"pone.0249535.ref010","first-page":"1","article-title":"The Electrically Evoked Compound Action Potential: From Laboratory to Clinic","volume":"11","author":"S He","year":"2017","journal-title":"Front Neurosci"},{"key":"pone.0249535.ref011","unstructured":"Azadpour M, Shapiro W, Svirsky M. 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