{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:31:46Z","timestamp":1787740306872,"version":"build-2784847793"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008968","name":"National Research Council Sri Lanka","doi-asserted-by":"publisher","award":["TO 14-05"],"award-info":[{"award-number":["TO 14-05"]}],"id":[{"id":"10.13039\/100008968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with \u2018traditional\u2019 chronic kidney disease (CKD). However, chronic kidney disease of uncertain aetiology (CKDu), a tubular interstitial nephropathy is typically minimally proteinuric without high rates of associated hypertension or vascular disease and it is unknown if the rates of CVD are similar. This study aimed to identify the prevalence and the risk of CVD in patients with CKDu. This cross-sectional study included patients with confirmed CKDu who were attending two renal clinics in CKDu endemic-area. A detailed medical history, blood pressure, electrocardiogram (resting and six minutes vigorous walking), echocardiograms, appropriate laboratory parameters and medical record reviews were used to collect data at baseline. The WHO\/Pan American Health Organization, cardiovascular risk calculator was employed to determine the future risk of CVD. The clinics had recorded 132 number of patients with CKDu, of these 119 consented to participation in the study. The mean age was 52 (\u00b1 9.5) years and mean eGFR was 51.1 (\u00b1 27.61); a majority (81.5% (n = 97)) were males. Thirty-four patients (28.6%) had evidence of ischaemic heart disease (IHD). Troponin-I (p = 0.02), Age &gt;50 years (p = 0.01) and hyperuricemia (p = 0.01) were significantly associated with IHD in CKDu. Left ventricular hypertrophy was reported in 20.2% (n = 24). According to the risk calculator, 97% of the enrolled patients were at low risk (&lt;10%) for experiencing a cardiovascular event within the next 10 years. Patients with CKDu have low prevalence and risk for CVD, implying that a majority are likely to survive to reach end-stage kidney disease. Our findings highlight the need for developing strategies to minimize the progression of CKDu to end-stage renal disease.<\/jats:p>","DOI":"10.1371\/journal.pone.0249539","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T21:40:57Z","timestamp":1618436457000},"page":"e0249539","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence, risk factors and predicted risk of cardiac events in chronic kidney disease of uncertain aetiology in Sri Lanka: A tubular interstitial nephropathy"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-2237","authenticated-orcid":true,"given":"Thilini W.","family":"Hettiarachchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-8649","authenticated-orcid":true,"given":"Buddhi N. T. 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Geneva: World Health Organization; 2007. http:\/\/www.who.int\/cardiovascular_diseases\/publications\/Prevention_of_Cardiovascular_Disease\/en\/ Accessed on 10 January 2020"},{"issue":"2","key":"pone.0249539.ref033","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1525-139X.2003.16025.x","article-title":"The clinical epidemiology of cardiovascular diseases in chronic kidney disease: Clinical Epidemiology of Cardiovascular Disease in Chronic Kidney Disease Prior to Dialysis","volume":"16","author":"A Levin","year":"2008","journal-title":"Seminars in Dialysis"},{"key":"pone.0249539.ref034","first-page":"55","article-title":", Clinical guidelines: The Endocrine Society of Sri Lanka; Management of obesity","volume":"4","author":"N Somasundaram","year":"2014","journal-title":"Sri Lanka J Diabetes"},{"key":"pone.0249539.ref035","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jama.300.8.924","article-title":"Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial","volume":"300","author":"DI Feig","year":"2008","journal-title":"JAMA"},{"key":"pone.0249539.ref036","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2008.05.022","article-title":"Uric acid: A marker of increased cardiovascular risk","volume":"202","author":"A Gagliardi","year":"2009","journal-title":"Atherosclerosis"},{"key":"pone.0249539.ref037","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12872-016-0379-z","article-title":"Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies","volume":"16","author":"T Zuo","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"pone.0249539.ref038","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/j.ajkd.2016.06.012","article-title":"Characterization of Mesoamerican nephropathy in a kidney failure hotspot in Nicaragua","volume":"68","author":"J. 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Aviles","year":"2002","journal-title":"N Engl J Med"},{"key":"pone.0249539.ref041","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1161\/01.CIR.0000041254.30637.34","article-title":"Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease","volume":"106","author":"F. S. 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