{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:59:30Z","timestamp":1792119570951,"version":"4.4.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"crossref","award":["26-18"],"award-info":[{"award-number":["26-18"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Allergic rhino-conjunctivitis with pollen allergy has been prevalent worldwide and Pollen-food allergy syndrome (PFAS) refers to individuals with pollen allergy who develop oral allergy syndrome (OAS) on consuming fruits and vegetables. The prevalence of PFAS varies by region and that in Japanese adolescents remains to be elucidated. In this cross-sectional study, we examined the epidemiological characteristics of PFAS in a general population of Japanese adolescents according to pollen allergy, OAS, and IgE component sensitization. Participants comprised adolescents, at age 13 years, from a prospective birth cohort study in Japan. We administered questionnaires to collect information from parents regarding pollen allergy, PFAS and OAS at each child\u2019s age 13 years. ImmunoCAP ISAC was used to assess IgE component sensitization. Among 506 participants with a complete questionnaire and ISAC measurement results, 56.5% had a history of hay fever, 16.0% had a history of OAS, 51.0% had pollen allergy, and 11.7% had a history of PFAS; additionally, 72.7% were sensitized to one or more tree, grass, and\/or weed allergens. The most common sensitization (95.7%) among adolescents with pollen allergy was to Japanese cedar (Cry j 1). The most common causal foods were kiwi and pineapple (both 39.0%). Knowledge levels about PFAS were poor among affected adolescents. We found a high prevalence of PFAS among adolescents in Japan. Although it affects approximately 1\/10 adolescents in the general population, public awareness regarding PFAS is poor. Interventional strategies are needed to increase knowledge and to prevent PFAS in the general population.<\/jats:p>","DOI":"10.1371\/journal.pone.0249649","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T22:49:00Z","timestamp":1618440540000},"page":"e0249649","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study"],"prefix":"10.1371","volume":"16","author":[{"given":"Tomoyuki","family":"Kiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":true,"given":"Kiwako","family":"Yamamoto-Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayako","family":"Saito-Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Irahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsune","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Inuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Toyokuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Miyaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Fukuie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-679X","authenticated-orcid":true,"given":"Masami","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"issue":"1","key":"pone.0249649.ref001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2222.1987.tb02317.x","article-title":"Oral allergy syndrome (OAS): symptoms of IgE\u2010mediated hypersensitivity to foods","volume":"17","author":"P Amlot","year":"1987","journal-title":"Clin Allergy"},{"issue":"1","key":"pone.0249649.ref002","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0091-6749(96)70252-X","article-title":"Pollen-food allergy syndrome","volume":"98","author":"MH Lessof","year":"1996","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"pone.0249649.ref003","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.anai.2019.07.022","article-title":"Pollen food allergy syndrome (PFAS): A review of current available literature","volume":"123","author":"G Carlson","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"pone.0249649.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pai.12563","article-title":"EAACI Molecular Allergology User\u2019s Guide","volume":"27","author":"PM Matricardi","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"pone.0249649.ref005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management","volume":"141","author":"S Sicherer","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"pone.0249649.ref006","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaip.2019.11.027","article-title":"Global trends in anaphylaxis epidemiology and clinical implications","volume":"8","author":"P Turner","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"8","key":"pone.0249649.ref007","first-page":"715","article-title":"Food and food additives hypersensitivity in adult asthmatics. II. Oral allergy syndrome in adult asthmatic with or without Japanese cedar hay fever","volume":"47","author":"Y Arai","year":"1998","journal-title":"Arerug\u012b = [Allergy]"},{"issue":"3","key":"pone.0249649.ref008","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.anai.2009.11.049","article-title":"Correlation of oral allergy syndrome due to plant-derived foods with pollen sensitization in Japan","volume":"104","author":"N Maeda","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"pone.0249649.ref009","first-page":"73","article-title":"Investigation of patients suffering from Japanese cedar pollinosis conducted through a questionnaire","volume":"50","author":"H Namba","year":"2004","journal-title":"Japanese Journal of Palynology"},{"issue":"4","key":"pone.0249649.ref010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.alit.2020.03.011","article-title":"The prevalence of oral symptoms caused by Rosaceae fruits and soybean consumption in children; a Japanese population-based survey","volume":"69","author":"M Sasaki","year":"2020","journal-title":"Allergol Int"},{"issue":"9111","key":"pone.0249649.ref011","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","article-title":"Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC","volume":"351","author":"of The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee","year":"1998","journal-title":"Lancet"},{"issue":"2","key":"pone.0249649.ref012","doi-asserted-by":"crossref","first-page":"100105","DOI":"10.1016\/j.waojou.2020.100105","article-title":"IgE responses to multiple allergen components among school-aged children in a general population birth cohort","volume":"13","author":"K Yamamoto-Hanada","year":"2020","journal-title":"Tokyo. World Allergy Organ J"},{"issue":"1","key":"pone.0249649.ref013","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.anai.2017.05.013","article-title":"Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5","volume":"119","author":"K Yamamoto-Hanada","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"pone.0249649.ref014","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/pai.12917","article-title":"Phenotypes of childhood wheeze in Japanese children: a group-based trajectory analysis","volume":"29","author":"L Yang","year":"2018","journal-title":"Pediatr Allergy Immunol"},{"issue":"9","key":"pone.0249649.ref015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s10038-019-0628-y","article-title":"Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study","volume":"64","author":"R Koseki","year":"2019","journal-title":"J Hum Genet"},{"issue":"6","key":"pone.0249649.ref016","doi-asserted-by":"crossref","first-page":"e0234161","DOI":"10.1371\/journal.pone.0234161","article-title":"Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: a prospective birth cohort study in Tokyo","volume":"15","author":"M Irahara","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"pone.0249649.ref017","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of asthma and allergies in childhood (ISAAC): rationale and methods","volume":"8","author":"M Asher","year":"1995","journal-title":"Eur Respir J"},{"issue":"3","key":"pone.0249649.ref018","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1183\/09031936.04.00090303","article-title":"Phase II of the international study of asthma and allergies in childhood (ISAAC II): rationale and methods","volume":"24","author":"S Weiland","year":"2004","journal-title":"Eur Respir J"},{"issue":"1","key":"pone.0249649.ref019","first-page":"10","article-title":"The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods","volume":"9","author":"ISAAC Steering Committee","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"issue":"8","key":"pone.0249649.ref020","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.jaip.2020.07.021","article-title":"Advances in IgE testing for diagnosis of allergic disease","volume":"8","author":"R Hamilton","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"pone.0249649.ref021","doi-asserted-by":"crossref","first-page":"e88394","DOI":"10.1371\/journal.pone.0088394","article-title":"Is the determination of specific IgE against components using ISAC 112 a reproducible technique?","volume":"9","author":"R Martinez-Aranguren","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"pone.0249649.ref022","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s40629-015-0087-8","article-title":"Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine","volume":"24","author":"T Jakob","year":"2015","journal-title":"Allergo J Int"},{"issue":"3","key":"pone.0249649.ref023","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1081-1206(10)63532-6","article-title":"Epidemiology of Japanese cedar pollinosis throughout Japan","volume":"91","author":"M Okuda","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"pone.0249649.ref024","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/all.13758","article-title":"Birch pollen allergy in Europe","volume":"74","author":"T Biedermann","year":"2019","journal-title":"Allergy"},{"issue":"4","key":"pone.0249649.ref025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2222.1994.tb00248.x","article-title":"IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy","volume":"24","author":"A Bircher","year":"1994","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"pone.0249649.ref026","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4168\/aair.2018.10.6.648","article-title":"Pollen-food allergy syndrome in Korean pollinosis patients: a nationwide survey","volume":"10","author":"M Kim","year":"2018","journal-title":"Allergy Asthma Immunol Res"},{"issue":"10","key":"pone.0249649.ref027","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/jpc.12658","article-title":"The prevalence of the oral allergy syndrome and pollen-food syndrome in an atopic paediatric population in south-west Sydney","volume":"50","author":"C Brown","year":"2014","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"pone.0249649.ref028","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.anl.2016.10.004","article-title":"Clinical benefit of component-resolved diagnosis in Japanese birch-allergic patients with a convincing history of apple or peach allergy","volume":"44","author":"H Shirasaki","year":"2017","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"pone.0249649.ref029","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mai.2000.106929","article-title":"Molecular and biochemical classification of plant-derived food allergens","volume":"106","author":"H Breiteneder","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"pone.0249649.ref030","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.alit.2019.09.008","article-title":"Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions","volume":"69","author":"Y Osawa","year":"2020","journal-title":"Allergol Int"},{"issue":"4","key":"pone.0249649.ref031","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1046\/j.0954-7894.2002.01337.x","article-title":"Assessment of cross-reactivity between Japanese cedar (Cryptomeria japonica) pollen and tomato fruit extracts by RAST inhibition and immunoblot inhibition","volume":"32","author":"Y Kondo","year":"2002","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"pone.0249649.ref032","first-page":"50","article-title":"Immunocytochemical localization of the allergenic proteins of Japanese cedar pollen and their origin","volume":"42","author":"S Nakamura","year":"2007","journal-title":"Kenbiky\u014d = Microscopy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T03:27:11Z","timestamp":1698895631000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249649"}},"subtitle":[],"editor":[{"given":"Linglin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0249649","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]}}}