{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:31:48Z","timestamp":1789763508550,"version":"4.0.1"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"None"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Introduction<\/jats:title><jats:p>Consideration of confounding factors about the association between Lower Respiratory Tract Infections (LRTI) in childhood and the development of subsequent wheezing has been incompletely described. We determined the association between viral LRTI at \u2264 5 years of age and the development of wheezing in adolescence or adulthood by a meta-analysis and a sensitivity analysis including comparable studies for major confounding factors.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>We performed searches through Pubmed and Global Index Medicus databases. We selected cohort studies comparing the frequency of subsequent wheezing in children with and without LRTI in childhood regardless of the associated virus. We extracted the publication data, clinical and socio-demographic characteristics of the children, and confounding factors. We analyzed data using random effect model.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The meta-analysis included 18 publications (22 studies) that met the inclusion criteria. These studies showed that viral LRTI in children \u2264 3 years was associated with an increased risk of subsequent development of wheezing (OR = 3.1, 95% CI = 2.4\u20133.9). The risk of developing subsequent wheezing was conserved when considering studies with comparable groups for socio-demographic and clinical confounders.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>When considering studies with comparable groups for most confounding factors, our results provided strong evidence for the association between neonatal viral LRTI and the subsequent wheezing development. Further studies, particularly from lower-middle income countries, are needed to investigate the role of non-bronchiolitis and non-HRSV LRTI in the association between viral LRTI in childhood and the wheezing development later. In addition, more studies are needed to investigate the causal effect between childhood viral LRTI and the wheezing development later.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Trial registration<\/jats:title><jats:p>Review registration: PROSPERO, CRD42018116955;<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42018116955\" xlink:type=\"simple\">https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42018116955<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0249831","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T17:59:16Z","timestamp":1618509556000},"page":"e0249831","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between early viral LRTI and subsequent wheezing development, a meta-analysis and sensitivity analyses for studies comparable for confounding factors"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-080X","authenticated-orcid":true,"given":"Sebastien","family":"Kenmoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnol","family":"Bowo-Ngandji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyprien","family":"Kengne-Nde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-889X","authenticated-orcid":true,"given":"Jean Thierry","family":"Ebogo-Belobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-0445","authenticated-orcid":true,"given":"Donatien Serge","family":"Mbaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadji","family":"Mahamat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Paola","family":"Demeni Emoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-6370","authenticated-orcid":true,"given":"Richard","family":"Njouom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"pone.0249831.ref001","article-title":"Incidence and characteristics of early childhood wheezing, Dhaka, Bangladesh, 2004\u20132010","author":"FS Dawood","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"pone.0249831.ref002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1385\/CRIAI:24:1:7","article-title":"Recurrent wheezing in infants and young children and bronchial hyperresponsiveness: a perspective","volume":"24","author":"RJ Hopp","year":"2003","journal-title":"Clin Rev Allergy Immunol"},{"key":"pone.0249831.ref003","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1651-2227.2007.00558.x","article-title":"Wheezy babies\u2014wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing","volume":"97","author":"E Piippo-Savolainen","year":"2008","journal-title":"Acta Paediatr"},{"key":"pone.0249831.ref004","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1164\/ajrccm.162.supplement_1.maic-11","article-title":"Protective and harmful effects of viral infections in childhood on wheezing disorders and asthma","volume":"162","author":"PJ Openshaw","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0249831.ref005","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0022-3476(71)80385-2","article-title":"The relationship between proved viral bronchiolitis and subsequent wheezing","volume":"79","author":"JC Rooney","year":"1971","journal-title":"The Journal of Pediatrics"},{"key":"pone.0249831.ref006","article-title":"Vaccines against human respiratory syncytial virus in clinical trials, where are we now?","author":"I Rossey","year":"2019","journal-title":"Expert Rev Vaccines"},{"key":"pone.0249831.ref007","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S2213-2600(20)30109-0","article-title":"Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis","volume":"8","author":"SM Brunwasser","year":"2020","journal-title":"Lancet Respir Med"},{"key":"pone.0249831.ref008","article-title":"Association Between Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection in Early Life and Recurrent Wheeze and Asthma in Later Childhood","author":"T Shi","year":"2019","journal-title":"J Infect Dis"},{"key":"pone.0249831.ref009","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1651-2227.2000.tb00359.x","article-title":"Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review","volume":"89","author":"MCJ Kneyber","year":"2000","journal-title":"Acta Paediatrica"},{"key":"pone.0249831.ref010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40121-017-0151-4","article-title":"The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood","volume":"6","author":"B Fauroux","year":"2017","journal-title":"Infect Dis Ther"},{"key":"pone.0249831.ref011","doi-asserted-by":"crossref","first-page":"e0242302","DOI":"10.1371\/journal.pone.0242302","article-title":"Systematic review and meta-analysis of the prevalence of common respiratory viruses in children < 2 years with bronchiolitis in the pre-COVID-19 pandemic era","volume":"15","author":"S Kenmoe","year":"2020","journal-title":"PLOS ONE"},{"key":"pone.0249831.ref012","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/jmv.23850","article-title":"Predicting the severity of acute bronchiolitis in infants: Should we use a clinical score or a biomarker?: Is a Biomarker Useful in Acute Bronchiolitis","volume":"86","author":"F Amat","year":"2014","journal-title":"Journal of Medical Virology"},{"key":"pone.0249831.ref013","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/jmv.23272","article-title":"Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system","volume":"84","author":"A Huguenin","year":"2012","journal-title":"J Med Virol"},{"key":"pone.0249831.ref014","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/ppul.20649","article-title":"Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis","volume":"42","author":"PS McNamara","year":"2007","journal-title":"Pediatric pulmonology"},{"key":"pone.0249831.ref015","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/INF.0b013e3182932f4f","article-title":"Analysis of Human Metapneumovirus and Human Bocavirus Viral Load","volume":"32","author":"S Ricart","year":"2013","journal-title":"The Pediatric Infectious Disease Journal"},{"key":"pone.0249831.ref016","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5578\/mb.7575","article-title":"Determination of the frequency of human bocavirus and other respiratory viruses among 0\u20132 years age group children diagnosed as acute bronchiolitis","volume":"48","author":"M Uyar","year":"2014","journal-title":"Mikrobiyoloji"},{"key":"pone.0249831.ref017","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"RF Lemanske","year":"2005","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"pone.0249831.ref018","doi-asserted-by":"crossref","first-page":"e013034","DOI":"10.1136\/bmjopen-2016-013034","article-title":"Association between rhinovirus wheezing illness and the development of childhood asthma: a meta-analysis","volume":"7","author":"L Liu","year":"2017","journal-title":"BMJ Open"},{"key":"pone.0249831.ref019","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/S0140-6736(12)61901-1","article-title":"Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis","volume":"381","author":"H Nair","year":"2013","journal-title":"Lancet"},{"key":"pone.0249831.ref020","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3325\/cmj.2013.54.122","article-title":"Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age\u2014a systematic review and meta-analysis","volume":"54","author":"I Luk\u0161i\u0107","year":"2013","journal-title":"Croat Med J"},{"key":"pone.0249831.ref021","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1164\/rccm.201405-0901PP","article-title":"Toward Primary Prevention of Asthma. 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A role for intervention studies","volume":"151","author":"CE Long","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0249831.ref023","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1513\/pats.200808-092RM","article-title":"The Origins of Asthma and Chronic Obstructive Pulmonary Disease in Early Life","volume":"6","author":"FD Martinez","year":"2009","journal-title":"Proc Am Thorac Soc"},{"issue":"Suppl 1","key":"pone.0249831.ref024","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1526-0542(09)70013-2","article-title":"term airway morbidity following viral LRTI in early infancy: recurrent wheezing or asthma?","volume":"10","author":"RT Stein","year":"2009","journal-title":"Paediatr Respir Rev"},{"key":"pone.0249831.ref025","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/jmv.25037","article-title":"RSV-hRV co-infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis","volume":"90","author":"F Amat","year":"2018","journal-title":"J Med Virol"},{"key":"pone.0249831.ref026","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0022-3476(81)80758-5","article-title":"Increased incidence of bronchial reactivity in children with a history of bronchiolitis","volume":"98","author":"D Gurwitz","year":"1981","journal-title":"J Pediatr"},{"key":"pone.0249831.ref027","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/adc.58.9.713","article-title":"Respiratory problems 2 years after acute bronchiolitis in infancy","volume":"58","author":"RL Henry","year":"1983","journal-title":"Arch Dis Child"},{"key":"pone.0249831.ref028","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.59.5.683","article-title":"Pulmonary function abnormalities in symptom-free children after bronchiolitis","volume":"59","author":"M Kattan","year":"1977","journal-title":"Pediatrics"},{"key":"pone.0249831.ref029","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1651-2227.1994.tb13131.x","article-title":"Bronchial asthma after early childhood wheezing: a follow-up until 4.5\u20136 years of age","volume":"83","author":"L Kuikka","year":"1994","journal-title":"Acta Paediatr"},{"key":"pone.0249831.ref030","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/bmj.284.6322.1070","article-title":"Atopy predisposing to acute bronchiolitis during an epidemic of respiratory syncytial virus","volume":"284","author":"I Laing","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"key":"pone.0249831.ref031","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates","volume":"332","author":"FD Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"pone.0249831.ref032","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/adc.59.4.299","article-title":"Symptoms, atopy, and bronchial reactivity after lower respiratory infection in infancy","volume":"59","author":"JY Mok","year":"1984","journal-title":"Arch Dis Child"},{"issue":"Suppl","key":"pone.0249831.ref033","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/BF02718159","article-title":"Acute and long-term effects of viral bronchiolitis in infancy","volume":"168","author":"JF Price","year":"1990","journal-title":"Lung"},{"key":"pone.0249831.ref034","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1651-2227.1988.tb10735.x","article-title":"Risk factors for occasional and recurrent wheezing after RSV infection in infancy","volume":"77","author":"E Rylander","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"pone.0249831.ref035","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM198810273191702","article-title":"Diminished lung function as a predisposing factor for wheezing respiratory illness in infants","volume":"319","author":"FD Martinez","year":"1988","journal-title":"N Engl J Med"},{"key":"pone.0249831.ref036","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ppul.1950030308","article-title":"Acute bronchiolitis: predisposing factors and characterization of infants at risk","volume":"3","author":"KH Carlsen","year":"1987","journal-title":"Pediatric pulmonology"},{"key":"pone.0249831.ref037","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0021-8707(59)90054-1","article-title":"The relationship between bronchiolitis and childhood asthma; a follow-up study of 100 cases of bronchiolitis","volume":"30","author":"HJ Wittig","year":"1959","journal-title":"J Allergy"},{"key":"pone.0249831.ref038","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1084\/jem.20021572","article-title":"Interactions between RSV Infection, Asthma, and Atopy","volume":"196","author":"PG Holt","year":"2002","journal-title":"J Exp Med"},{"key":"pone.0249831.ref039","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2007.02.032","article-title":"Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing","volume":"151","author":"EAF Simoes","year":"2007","journal-title":"J Pediatr"},{"key":"pone.0249831.ref040","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1542\/peds.2013-0982","article-title":"Effect of palivizumab prophylaxis on subsequent recurrent wheezing in preterm infants","volume":"132","author":"S Yoshihara","year":"2013","journal-title":"Pediatrics"},{"key":"pone.0249831.ref041","volume-title":"CRD\u2019s guidance for undertaking reviews in 301 healthcare: centers for reviews and dissemination","author":"Centers for Reviews and Dissemination","year":"2009"},{"key":"pone.0249831.ref042","first-page":"6","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"pone.0249831.ref043","first-page":"5","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","author":"M Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"pone.0249831.ref044","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jclinepi.2011.11.014","article-title":"Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement","volume":"65","author":"D Hoy","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"pone.0249831.ref045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"R DerSimonian","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"pone.0249831.ref046","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1467-985X.2008.00552.x","article-title":"A re-evaluation of random-effects meta-analysis","volume":"172","author":"JPT Higgins","year":"2009","journal-title":"J R Stat Soc Ser A Stat Soc"},{"key":"pone.0249831.ref047","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JPT Higgins","year":"2002","journal-title":"Stat Med"},{"key":"pone.0249831.ref048","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2307\/3001666","article-title":"The Combination of Estimates from Different Experiments","volume":"10","author":"WG Cochran","year":"1954","journal-title":"Biometrics"},{"key":"pone.0249831.ref049","first-page":"14","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","author":"X Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"pone.0249831.ref050","first-page":"40","article-title":"meta: An R package for meta-analysis","volume":"7","author":"G Schwarzer","year":"2007","journal-title":"R News"},{"key":"pone.0249831.ref051","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"S Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"pone.0249831.ref052","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cyto.2015.07.017","article-title":"Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing","volume":"76","author":"P Bertrand","year":"2015","journal-title":"Cytokine"},{"key":"pone.0249831.ref053","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2431-5-31","article-title":"Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway","volume":"5","author":"H-O Fj\u00e6rli","year":"2005","journal-title":"BMC Pediatr"},{"key":"pone.0249831.ref054","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ppul.20597","article-title":"Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5","volume":"42","author":"ML Garc\u00eda-Garc\u00eda","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"pone.0249831.ref055","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-3038.2005.00298.x","article-title":"Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study","volume":"16","author":"J Henderson","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"pone.0249831.ref056","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1398-9995.2003.00233.x","article-title":"Association of an early respiratory syncytial virus infection and atopic allergy","volume":"58","author":"H Juntti","year":"2003","journal-title":"Allergy"},{"key":"pone.0249831.ref057","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.rmed.2005.08.013","article-title":"-EPX levels and wheezing in infants and young children with and without RSV bronchiolitis","volume":"100","author":"S Kristj\u00e1nsson","year":"2006","journal-title":"Respir Med"},{"key":"pone.0249831.ref058","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/BF01957225","article-title":"Recurrent wheezing in children with respiratory syncytial virus (RSV) bronchiolitis in Qatar","volume":"152","author":"VM Osundwa","year":"1993","journal-title":"Eur J Pediatr"},{"key":"pone.0249831.ref059","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1378\/chest.10-0365","article-title":"Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins","volume":"138","author":"P Poorisrisak","year":"2010","journal-title":"Chest"},{"key":"pone.0249831.ref060","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.284.6330.1665","article-title":"Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy","volume":"284","author":"CR Pullan","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"key":"pone.0249831.ref061","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/peds.95.4.500","article-title":"Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls","volume":"95","author":"N Sigurs","year":"1995","journal-title":"Pediatrics"},{"key":"pone.0249831.ref062","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/thx.2009.121582","article-title":"Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life","volume":"65","author":"N Sigurs","year":"2010","journal-title":"Thorax"},{"key":"pone.0249831.ref063","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","article-title":"Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7","volume":"161","author":"N Sigurs","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"pone.0249831.ref064","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"N Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0249831.ref065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bmj.1.6104.11","article-title":"Study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy","volume":"1","author":"DG Sims","year":"1978","journal-title":"Br Med J"},{"key":"pone.0249831.ref066","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.112.2.285","article-title":"Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska Native children","volume":"112","author":"RJ Singleton","year":"2003","journal-title":"Pediatrics"},{"key":"pone.0249831.ref067","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/adc.59.10.935","article-title":"Factors predisposing to abnormal pulmonary function after adenovirus type 7 pneumonia","volume":"59","author":"PD Sly","year":"1984","journal-title":"Arch Dis Child"},{"key":"pone.0249831.ref068","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0037-1606565","article-title":"Wheeze after Hospitalization for Respiratory Syncytial Virus Infection","volume":"13","author":"LG Stensballe","year":"2018","journal-title":"Children. Journal of Pediatric Infectious Diseases"},{"key":"pone.0249831.ref069","first-page":"9","article-title":"Increased Risk of Wheeze and Decreased Lung Function after Respiratory Syncytial Virus Infection","author":"K Zomer-Kooijker","year":"2014","journal-title":"PLoS One"},{"key":"pone.0249831.ref070","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1651-2227.2000.tb00359.x","article-title":"Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review","volume":"89","author":"MCJ Kneyber","year":"2000","journal-title":"Acta Paediatrica"},{"key":"pone.0249831.ref071","article-title":"The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood","author":"B Fauroux","year":"2017","journal-title":"Infect Dis Ther"},{"key":"pone.0249831.ref072","first-page":"7","article-title":"Long Term Sequelae from Childhood Pneumonia; Systematic Review and Meta-Analysis","author":"K Edmond","year":"2012","journal-title":"PLoS One"},{"key":"pone.0249831.ref073","article-title":"Association between Respiratory Syncytial Virus Hospitalizations in Infants and Respiratory Sequelae: Systematic Review and Meta-Analysis","volume":"1","author":"S R\u00e9gnier","year":"2013","journal-title":"The Pediatric Infectious Disease Journal"},{"key":"pone.0249831.ref074","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jaci.2008.10.043","article-title":"Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze","volume":"123","author":"LG Stensballe","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"pone.0249831.ref075","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bmj.312.7040.1195","article-title":"Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort","volume":"312","author":"DP Strachan","year":"1996","journal-title":"BMJ"},{"key":"pone.0249831.ref076","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1164\/ajrccm.165.2.2104032","article-title":"A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status","volume":"165","author":"HL Rhodes","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0249831.ref077","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"RT Stein","year":"1999","journal-title":"Lancet"},{"key":"pone.0249831.ref078","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-3038.2012.01283.x","article-title":"The outcome after severe bronchiolitis is related to gender and virus","volume":"23","author":"IB Mikalsen","year":"2012","journal-title":"Pediatr Allergy Immunol"},{"key":"pone.0249831.ref079","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ppul.1950150204","article-title":"Pulmonary function between 6 and 18 years of age","volume":"15","author":"X Wang","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"pone.0249831.ref080","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/oxfordjournals.aje.a009748","article-title":"Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children\u2019s Respiratory Study","volume":"149","author":"RT Stein","year":"1999","journal-title":"Am J Epidemiol"},{"key":"pone.0249831.ref081","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1164\/ajrccm.163.supplement_1.2011111","article-title":"Potential mechanisms causing delayed effects of respiratory syncytial virus infection","volume":"163","author":"PJ Openshaw","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0249831.ref082","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/adc.74.3.251","article-title":"Why do viruses make infants wheeze?","volume":"74","author":"IM Balfour-Lynn","year":"1996","journal-title":"Arch Dis Child"},{"key":"pone.0249831.ref083","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1164\/ajrccm\/143.2.312","article-title":"Initial airway function is a risk factor for recurrent wheezing respiratory illnesses during the first three years of life. Group Health Medical Associates","volume":"143","author":"FD Martinez","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"pone.0249831.ref084","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.72.1.16","article-title":"Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis","volume":"72","author":"S Young","year":"1995","journal-title":"Arch Dis Child"},{"key":"pone.0249831.ref085","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1164\/ajrccm\/147.4.811","article-title":"Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life","volume":"147","author":"IB Tager","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"pone.0249831.ref086","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ppul.22842","article-title":"Increased asthma risk and impaired quality of life after bronchiolitis or pneumonia in infancy: Asthma Risk After Early Bronchiolitis or Pneumonia","volume":"49","author":"K Backman","year":"2014","journal-title":"Pediatric Pulmonology"},{"key":"pone.0249831.ref087","doi-asserted-by":"crossref","first-page":"e0121906","DOI":"10.1371\/journal.pone.0121906","article-title":"A Longitudinal Study on Early Hospitalized Airway Infections and Subsequent Childhood Asthma","volume":"10","author":"M-J Jeng","year":"2015","journal-title":"PLOS ONE"},{"key":"pone.0249831.ref088","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/iid3.77","article-title":"Rhinovirus wheezing illness in infancy is associated with medically attended third year wheezing in low risk infants: results of a healthy birth cohort study","volume":"3","author":"JJH de Winter","year":"2015","journal-title":"Immun Inflamm Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T11:42:17Z","timestamp":1671882137000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0249831"}},"subtitle":[],"editor":[{"given":"Bernadette","family":"van den Hoogen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":88,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0249831","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}