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Animal models of CKD have shown variability in the skeletal response to CKD between males and females suggesting sex may play a role in this variation. Our aim was to compare the impact of adenine-induced CKD on cortical parameters in skeletally mature male and female C57Bl\/6 mice. After 10-weeks of adenine-induced CKD, both male and female adenine mice had high serum parathyroid hormone (PTH), high bone turnover, and cortical porosity compared to non-CKD controls. Both sexes had lower cortical thickness, but only male mice had lower cortical bone area. CKD imparted greater deficits in mechanical properties of male mice compared to female mice. These data demonstrate that both male and female mice develop high PTH\/high bone turnover in response to adenine-induced CKD and that cortical bone phenotypes are slightly more severe in males, particularly in mechanical properties deficits.<\/jats:p>","DOI":"10.1371\/journal.pone.0250438","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T14:09:55Z","timestamp":1619186995000},"page":"e0250438","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL\/6 mice with more severe deficits in cortical bone properties of male mice"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-8082","authenticated-orcid":true,"given":"Corinne E.","family":"Metzger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Swallow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Stacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"pone.0250438.ref001","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"TL Nickolas","year":"2013","journal-title":"J Bone Miner Res"},{"key":"pone.0250438.ref002","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jbmr.2862","article-title":"Hip Fracture in Patients With Non-Dialysis-Requiring Chronic Kidney Disease","volume":"31","author":"SM Kim","year":"2016","journal-title":"J Bone Miner Res"},{"key":"pone.0250438.ref003","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00198-013-2435-1","article-title":"Incidence and risk factors for hip fractures in dialysis patients","volume":"25","author":"M Maravic","year":"2014","journal-title":"Osteoporos Int"},{"key":"pone.0250438.ref004","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"AM Alem","year":"2000","journal-title":"Kidney Int"},{"key":"pone.0250438.ref005","first-page":"1","article-title":"Increased risks of mortality and atherosclerotic complications in incident hemodialysis patients subsequently with bone fractures: A nationwide case-matched cohort study","volume":"10","author":"CH Kuo","year":"2015","journal-title":"PLoS One"},{"key":"pone.0250438.ref006","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ki.2013.279","article-title":"High rates of death and hospitalization follow bone fracture among hemodialysis patients","volume":"85","author":"F Tentori","year":"2014","journal-title":"Kidney Int"},{"key":"pone.0250438.ref007","unstructured":"Prevention C for DC and (2019) Chronic Kidney Disease in the United States, 2019. 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