{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:40:38Z","timestamp":1787380838746,"version":"build-2736575974"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["95020"],"award-info":[{"award-number":["95020"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The burden of STIs is particularly high in HIV-infected MSM patients. A recent increase in STIs prevalence has been noticed in the US and western European countries. We aim to assess trends in asymptomatic STIs following the publication of recommendations for STIs screening, i.e. Chlamydia (CT) and gonorrhea (NG). Seventeen centers located in the Paris area participated in the study. All asymptomatic HIV-infected MSM patients attending a follow up consultation were proposed to participated in the study. Asymptomatic patients were included over 2 periods: period 1 from April to December 2015 and period 2 from September to December 2017. Etiologic diagnosis of STIs including hepatitis B, C, syphilis, was performed using a serological test, including a non-treponemal titer with a confirmatory treponemal assay for syphilis. CT and NG were screened using a nucleic acid amplification test (NAATs) on 3 anatomical sites, i.e. urine, rectal and pharyngeal. Overall, 781 patients were included: 490 and 291 in periods 1 and 2 respectively. Asymptomatic CT, NG, and syphilis were diagnosed in 7.5%, 4.8% and, 4.2% respectively. The rate of patients having a multisite asymptomatic infection was 10.2% and 21.1% for CT and NG respectively. The most frequently involved anatomical sites for CT and NG asymptomatic infections were anorectal (66.1% and 55.2% respectively) and pharyngeal (47.4% and 60.5% respectively). CT and NG asymptomatic infection increased by 1.3- and 2-fold respectively between the two periods while syphilis decreased by 3 folds. Our results encourage to reconsider multisite screening for CT and NG in asymptomatic HIV positive MSM as the yield of screening urinary samples only might be low. Despite the more systematic STI screening of asymptomatic HIV positive MSM the prevalence of STI is increasing in MSM in France. Therefore, this strategy has not led to alter CT and NG transmission. The decrease of syphilis might involve self-medication by doxycycline, and the intensification of syphilis screening.<\/jats:p>","DOI":"10.1371\/journal.pone.0250557","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T17:38:19Z","timestamp":1624556299000},"page":"e0250557","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Trends in asymptomatic STI among HIV-positive MSM and lessons for systematic screening"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-8018","authenticated-orcid":true,"given":"Eric","family":"Farfour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlane","family":"Dimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chassany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fou\u00e9r\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Valin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Duvivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Duracinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zucman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the DRIVER study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"pone.0250557.ref001","doi-asserted-by":"crossref","first-page":"e020336","DOI":"10.1136\/bmjopen-2017-020336","article-title":"Relevance of healthcare reimbursement data to monitor syphilis epidemic: an alternative surveillance through the national health insurance database in France, 2011\u20132013","volume":"8","author":"N Ndeikoundam Ngangro","year":"2018","journal-title":"BMJ Open"},{"key":"pone.0250557.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0205863","article-title":"Adult gonorrhea, chlamydia and syphilis prevalence, incidence, treatment and syndromic case reporting in South Africa: Estimates using the Spectrum-STI model, 1990\u20132017","volume":"13","author":"RS Kularatne","year":"2018","journal-title":"PLoS One"},{"key":"pone.0250557.ref003","article-title":"Bacterial sexually transmitted infections in France: Recent trends and patients\u2019 characteristics in 2016","volume":"24","author":"NN Ngangro","year":"2019","journal-title":"Eurosurveillance"},{"key":"pone.0250557.ref004","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.medmal.2017.06.004","article-title":"Increase in sexually transmitted infections in a cohort of outpatient HIV-positive men who have sex with men in the Parisian region","volume":"47","author":"E Farfour","year":"2017","journal-title":"M\u00e9decine Mal Infect"},{"key":"pone.0250557.ref005","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/cid\/cix458","article-title":"How to face the outbreak of viral hepatitis a in men who have sex with men in France without vaccines?","volume":"65","author":"D Zucman","year":"2017","journal-title":"Clin Infect Dis"},{"key":"pone.0250557.ref006","first-page":"22","article-title":"Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017","author":"K Beebeejaun","year":"2017","journal-title":"Euro Surveill"},{"key":"pone.0250557.ref007","first-page":"849","article-title":"[Supply disruptions and drug shortages: the example of benzathine benzylpenicillin].","volume":"68","author":"A Dhanani","year":"2018","journal-title":"Rev Prat"},{"key":"pone.0250557.ref008","author":"Haute Autorit\u00e9 de Sant\u00e9","year":"2018","journal-title":"R\u00e9\u00e9valuation de la strat\u00e9gie de d\u00e9pistage des infections \u00e0 Chlamydia trachomatis"},{"key":"pone.0250557.ref009","first-page":"1","article-title":"Centers for Disease Control and Prevention. 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