{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:31:47Z","timestamp":1790116307659,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Society of Ultrasound in Obstetrics and Gynecology"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The aim of this study was to evaluate the hourly fetal urine production rate (HFUPR) via three-dimensional ultrasonography in women with isolated oligohydramnios and compare with normal pregnant women at term.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>This was a prospective observational cohort study of 112 women from 34 to 40 6\/7 weeks\u2019 gestation. They were classified into three groups according to the amniotic fluid index (AFI) and ultrasonographic estimated fetal weight (EFW) as isolated oligohydramnios (defined as AFI below 5% and appropriate EFW corresponding to gestational age) (n = 34) and IUGR (defined as EFW below 5% corresponding to gestational age irrespective amniotic fluid) (n = 17), and normal pregnancy (n = 61). HFUPR was measured using three-dimensional virtual organ computer-aided analysis. Adverse perinatal outcomes in all participants were examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>There was no significant difference in HFUPR between patients with isolated oligohydramnios and women with normal pregnancies (median, 40.0 mL\/h [interquartile range [IQR] 31.0\u201366.5] vs. 48.6 [31.5\u201381.2], p = 0.224). HFUPR was significantly decreased in the IUGR group (13.8 mL\/h [IQR 10.1\u201324.8]), compared to the normal pregnancy group (p&lt;0.001) and the isolated oligohydramnios group (p&lt;0.001). HFUPR was significantly decreased in neonates with adverse perinatal outcomes compared to the control (24.7 mL\/h [IQR 13.4\u201347.4] vs. 43.6 [29.8\u201379.0], p = 0.016).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>HFUPR was not decreased in patients with isolated oligohydramnios but was decreased in patients with IUGR when compared to normal controls at term.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0250659","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T17:29:13Z","timestamp":1621618153000},"page":"e0250659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hourly fetal urine production rate in isolated oligohydramnios at 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