{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:23:52Z","timestamp":1772781832611,"version":"3.50.1"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography (SS-OCTA).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this prospective, case-controlled study, patients with NF1 and age-matched control subjects were quantitatively analyzed by using multimodal imaging. All the subjects underwent confocal scanning laser ophthalmoscopy (SLO), SS-OCT and SS-OCTA examinations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>SS-OCT analysis revealed a lower macular retinal nerve fiber layer (RNFL) thickness in patients with NF1 compared with those with suspected NF1 (95.0\u00b115.9 vs 109.7\u00b111.3 \u03bcm; <jats:italic>P<\/jats:italic> = 0.001) and control subjects (106.8\u00b114.4 \u03bcm, <jats:italic>P<\/jats:italic> = 0.003). Retinal thickness was significantly lower in NF1 patients compared to those with suspected NF1 (280.7\u00b123.0 vs 304.2\u00b115.3 \u03bcm; <jats:italic>P<\/jats:italic> &lt; 0.001) and control subjects (298.7\u00b123.8 \u03bcm, <jats:italic>P<\/jats:italic> = 0.003). The mean vascular flow area of the SCP was significantly higher in patients with NF1 (42.6\u00b12.2%) and suspected NF1 (43.1\u00b12.5%) compared to control subjects (41.0\u00b12.0%; respectively, <jats:italic>P<\/jats:italic> = 0.017 and <jats:italic>P<\/jats:italic> = 0.002). In the second choroidal layer, the flow area was significantly lower in patients with NF1 compared to control subjects (45.4\u00b14.8 vs 49.0\u00b14.0%,; <jats:italic>P<\/jats:italic> = 0.011).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Retinal thicknesses alterations and choroidal nodules are described as ocular manifestations in patients with NF1. In addition, OCTA could represent an important novel advanced imaging technique, capable of detecting early altered retinal and choroidal vascular flow area in patients with NF1.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0251098","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T18:16:40Z","timestamp":1620325000000},"page":"e0251098","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by 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