{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:01:52Z","timestamp":1789268512667,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>To investigate the effects of short-term exposure to sulfur dioxide (SO<jats:sub>2<\/jats:sub>) and carbon monoxide (CO) in the central and southern China areas on ischemic heart disease (IHD) and non-accidental death<jats:italic>s<\/jats:italic>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>We investigated the associations between short-term exposure to SO<jats:sub>2<\/jats:sub> and CO in a city in south-central China and IHD and non-accidental death using a time-series design and generalized additive models with up to a 5-day lag adjusting for day of the week, temperature, air pressure, wind speed, and relative humidity. The relative risks of IHD and non-accidental death per 10-unit increase in SO<jats:sub>2<\/jats:sub> and CO were derived from zero to five days in single-pollutant models.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Between 2016 and 2018, a total of 10,507 IHD and 44,070 non-accidental deaths were identified. The largest significant relative risk for IHD death was lag 02 for both SO<jats:sub>2<\/jats:sub> (1.080; 95% confidence interval: 1.075\u20131.084) and CO (5.297; 95% confidence interval: 5.177\u20135.418) in single-pollutants models. A significant association was shown at all lag multiple-day moving averages. Two-pollutant models identified an association between SO<jats:sub>2<\/jats:sub> and mortality when adjusting for CO. In stratified analyses, SO<jats:sub>2<\/jats:sub> exhibited a stronger association with death during the cold season, while CO exhibited a stronger association with mortality from IHD during the warm season. The risk of death was more robust in the elderly for both pollutants, but was greater in men for CO and in women for SO<jats:sub>2<\/jats:sub>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Overall, we found an association between short-term exposure to low-level SO<jats:sub>2<\/jats:sub> and CO and the risk of IHD and non-accidental death.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0251108","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T17:30:37Z","timestamp":1620063037000},"page":"e0251108","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between short-term exposure to sulfur dioxide and carbon monoxide and ischemic heart disease and non-accidental death in Changsha city, China"],"prefix":"10.1371","volume":"16","author":[{"given":"Zenghui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-5928","authenticated-orcid":true,"given":"Lili","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"pone.0251108.ref001","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"GA Roth","year":"2018","journal-title":"The Lancet"},{"key":"pone.0251108.ref002","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"H Wang","year":"2016","journal-title":"The Lancet"},{"key":"pone.0251108.ref003","article-title":"Acute Effects of Particulate Air Pollution on Ischemic Heart Disease Hospitalizations in Shanghai, China","volume":"14","author":"A Xu","year":"2017","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0251108.ref004","article-title":"A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide","volume":"15","author":"ZF Chen","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0251108.ref005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.atmosenv.2018.05.033","article-title":"Association between ambient particulate matter concentrations and hospitalization for ischemic heart disease (I20-I25, ICD-10) in China: A multicity case-crossover study","volume":"186","author":"X Dai","year":"2018","journal-title":"Atmospheric Environment"},{"key":"pone.0251108.ref006","article-title":"Association between air pollution and daily mortality and hospital admission due to Ischaemic heart diseases in Hong Kong","volume":"120","author":"W Tam","year":"2015","journal-title":"Atmospheric Environment"},{"key":"pone.0251108.ref007","unstructured":"WHO. 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