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Here we investigate the role of\n                    <jats:italic>Rora<\/jats:italic>\n                    across CD4+ T cells in general, but with an emphasis on Th2 cells, both\n                    <jats:italic>in vitro<\/jats:italic>\n                    as well as in the context of several\n                    <jats:italic>in vivo<\/jats:italic>\n                    type 2 infection models. We dissect the function of\n                    <jats:italic>Rora<\/jats:italic>\n                    using overexpression and a CD4-conditional\n                    <jats:italic>Rora-<\/jats:italic>\n                    knockout mouse, as well as a RORA-reporter mouse. We establish the importance of\n                    <jats:italic>Rora<\/jats:italic>\n                    in CD4+ T cells for controlling lung inflammation induced by\n                    <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>\n                    infection, and have measured the effect on downstream genes using RNA-seq. Using a systematic stimulation screen of CD4+ T cells, coupled with RNA-seq, we identify upstream regulators of\n                    <jats:italic>Rora<\/jats:italic>\n                    , most importantly IL-33 and CCL7. Our data suggest that\n                    <jats:italic>Rora<\/jats:italic>\n                    is a negative regulator of the immune system, possibly through several downstream pathways, and is under control of the local microenvironment.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0251233","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:41:43Z","timestamp":1621345303000},"page":"e0251233","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Mapping Rora expression in resting and activated CD4+ T cells"],"prefix":"10.1371","volume":"16","author":[{"given":"Liora","family":"Haim-Vilmovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-2844","authenticated-orcid":true,"given":"Johan","family":"Henriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-9815","authenticated-orcid":true,"given":"Zhichao","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eviatar","family":"Natan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Clare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Barlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Charidemou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lira","family":"Mamanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-4206","authenticated-orcid":true,"given":"Valentina","family":"Proserpio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhuma","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Woodhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Protasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Efremova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian L.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-0377","authenticated-orcid":true,"given":"Matt","family":"Berriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Marioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N. 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