{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:41:41Z","timestamp":1759941701414,"version":"3.40.5"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chaire Fondation Caroline Durand en audition et vieillissement de l\u2019Universit\u00e9 de Montr\u00e9al"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Some evidence suggests that young adults exhibit a selective laterality of auditory brainstem response (ABR) elicited with speech stimuli. Little is known about such an auditory laterality in older adults.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate possible asymmetric auditory brainstem processing between right and left ear presentation in older adults.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Methods<\/jats:title><jats:p>Sixty-two older adults presenting with normal hearing thresholds according to their age and who were native speakers of Quebec French participated in this study. ABR was recorded using click and a 40-ms \/da\/ syllable. ABR was elicited through monaural right and monaural left stimulation. Latency and amplitude for click-and speech-ABR components were compared between right and left ear presentations. In addition, for the \/da\/ syllable, a fast Fourier transform analysis of the sustained frequency-following response (FFR) of the vowel was performed along with stimulus-to-response and right-left ear correlation analyses.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Results<\/jats:title><jats:p>No significant differences between right and left ear presentation were found for amplitudes and latencies of the click-ABR components. Significantly shorter latencies for right ear presentation as compared to left ear presentation were observed for onset and offset transient components (V, A and O), sustained components (D and E), and voiced transition components (C) of the speech-ABR. In addition, the spectral amplitude of the fundamental frequency (F0) was significantly larger for the left ear presentation than the right ear presentation.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Conclusions<\/jats:title><jats:p>Results of this study show that older adults with normal hearing exhibit symmetric encoding for click stimuli at the brainstem level between the right and left ear presentation. However, they present with brainstem asymmetries for the encoding of selective stimulus components of the speech-ABR between the right and left ear presentation. The right ear presentation of a \/da\/ syllable elicited reduced neural timing for both transient and sustained components compared to the left ear. Conversely, a stronger left ear F0 encoding was observed. These findings suggest that at a preattentive, sensory stage of auditory processing, older adults lateralize speech stimuli similarly to young adults.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0251287","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T18:03:32Z","timestamp":1620410612000},"page":"e0251287","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Auditory brainstem response asymmetries in older adults: An exploratory study using click and speech stimuli"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-3969","authenticated-orcid":true,"given":"Alejandro","family":"Ianiszewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Fuente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Gagn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"pone.0251287.ref001","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-3782(96)01732-X","article-title":"Functional auditory development in preterm and full-term infants","volume":"45","author":"L Eldredge","year":"1996","journal-title":"Early Hum Dev"},{"key":"pone.0251287.ref002","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.heares.2005.12.003","article-title":"Lateral asymmetry in the ABR of neonates: Evidence and mechanisms","volume":"212","author":"YS Sininger","year":"2006","journal-title":"Hear Res"},{"key":"pone.0251287.ref003","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0378-5955(98)00152-X","article-title":"Gender distinctions and lateral asymmetry in the low-level auditory brainstem response of the human neonate","volume":"126","author":"YS Sininger","year":"1998","journal-title":"Hear Res"},{"key":"pone.0251287.ref004","first-page":"27","article-title":"Normative bilateral brainstem evoked response data for a naval aviation student population: Groups statistics","author":"C Hixson","year":"1978","journal-title":"Nav Aerosp Med Res Lab Pensacola Fla"},{"key":"pone.0251287.ref005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0013-4694(78)90030-5","article-title":"Norma variability of the brain-stem auditory evoked response in young and old adult subjects","volume":"44","author":"J Rowe","year":"1978","journal-title":"Electroencephalography and Clin Neurophysiol"},{"issue":"2","key":"pone.0251287.ref006","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/01050399009070755","article-title":"Individual Differences in Auditory Electric Responses III. A Replication, with Observations of Individual vs. Group Characteristics","volume":"19","author":"J Lauter","year":"1990","journal-title":"Scandinavian audiology"},{"issue":"3","key":"pone.0251287.ref007","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000188533","article-title":"Subcortical laterality of speech encoding","volume":"14","author":"J Hornickel","year":"2009","journal-title":"Audiol Neurootol"},{"issue":"1","key":"pone.0251287.ref008","first-page":"101","article-title":"Lateral asymmetry in speech processing at the brainstem: evidence from speech evoked ABR","volume":"29","author":"K Sinha","year":"2010","journal-title":"JAIISH"},{"key":"pone.0251287.ref009","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/AUD.0b013e3181f534b5","article-title":"Brain stem responses to speech in younger and older adults","volume":"32","author":"KR Vander Werff","year":"2011","journal-title":"Ear Hear"},{"issue":"8","key":"pone.0251287.ref010","first-page":"637","article-title":"Diffusion tensor imaging of the central auditory system in the elderly","volume":"30","author":"L Peng","year":"2016","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"4","key":"pone.0251287.ref011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/14992027.2013.866281","article-title":"Effects of stimulus presentation mode and subcortical laterality in speech evoked auditory brainstem responses","volume":"53","author":"M Ahadi","year":"2014","journal-title":"International Journal of Audiology"},{"key":"pone.0251287.ref012","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bandl.2011.05.001","article-title":"Functional ear (a)symmetry in brainstem neural activity relevant to encoding of voice pitch: A precursor for hemispheric specialization?","volume":"119","author":"A Krishnan","year":"2011","journal-title":"Brain & Language"},{"key":"pone.0251287.ref013","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0013-4694(83)90163-3","article-title":"Right-left asymmetries in the human brain stem: auditory evoked potentials","volume":"55","author":"R Levine","year":"1983","journal-title":"Electroencephalography and Clin Neurophysiol"},{"issue":"4","key":"pone.0251287.ref014","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0028-3932(88)90116-9","article-title":"The brainstem auditory evoked potential asymmetry is replicable and reliable","volume":"26","author":"R Levine","year":"1988","journal-title":"Neuropsychologia"},{"issue":"2","key":"pone.0251287.ref015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/cercor\/bhj165","article-title":"Hemispheric asymmetry for auditory processing in the human auditory brain stem, thalamus, and cortex","volume":"17","author":"M Sch\u00f6nwiesner","year":"2007","journal-title":"Cerebral Cortex"},{"issue":"2","key":"pone.0251287.ref016","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3940(98)00615-6","article-title":"Functional asymmetries of crossed and uncrossed medial olivocochlear efferent pathways in humans","volume":"253","author":"B Philibert","year":"1998","journal-title":"Neuroscience letters"},{"issue":"1\u20132","key":"pone.0251287.ref017","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.heares.2004.07.019","article-title":"Hemispheric asymmetry of the right ear advantage in dichotic listening","volume":"198","author":"J Jerger","year":"2004","journal-title":"Hearing research"},{"issue":"2","key":"pone.0251287.ref018","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bandc.2010.11.009","article-title":"From ear to brain","volume":"76","author":"D. Kimura","year":"2011","journal-title":"Brain and Cognition"},{"key":"pone.0251287.ref019","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1523\/JNEUROSCI.20-02-00791.2000","article-title":"Aging affects the hemispheric asymmetry in the neural representation of speech sounds","volume":"20","author":"TJ Bellis","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"pone.0251287.ref020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fnagi.2016.00133","article-title":"Aging Affects Neural Synchronization to Speech-Related Acoustic Modulations","volume":"8","author":"T Goossens","year":"2016","journal-title":"Front. Aging Neurosci"},{"key":"pone.0251287.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/735290","article-title":"Age- associated reduction of asymmetry in human central auditory function: a 1H-magnetic resonance spectroscopy study","author":"X Chen","year":"2013","journal-title":"Neural Plast"},{"issue":"4","key":"pone.0251287.ref022","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/AUD.0000000000000274","article-title":"Age-Related Changes in Binaural Interaction at Brainstem Level","volume":"37","author":"LN Van Yper","year":"2016","journal-title":"Ear Hear"},{"key":"pone.0251287.ref023","first-page":"1871","article-title":"Asymmetry in the auditory brainstem response following experience of monaural amplification","volume":"18","author":"K Munro","year":"2007","journal-title":"Neuro Report"},{"key":"pone.0251287.ref024","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1162\/089892998562834","article-title":"Lateralization of speech and auditory temporal processing","volume":"10","author":"P Belin","year":"1998","journal-title":"J Cognit Neurosci"},{"issue":"3","key":"pone.0251287.ref025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainresrev.2003.08.004","article-title":"Lateralization of auditory-cortex functions","volume":"43","author":"M Tervaniemi","year":"2003","journal-title":"Brain Res Rev"},{"key":"pone.0251287.ref026","first-page":"133","article-title":"Asymmetric frequency following responses","volume":"5","author":"B Ballachanda","year":"1994","journal-title":"J Am Acad Audiol"},{"key":"pone.0251287.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0042-1748003","article-title":"Frequency-following response: Effects of interaural time and intensity differences","volume":"11","author":"B Ballachanda","year":"2000","journal-title":"J Am Acad Audiol"},{"issue":"5058","key":"pone.0251287.ref028","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1589767","article-title":"Lateralization of phonetic and pitch discrimination in speech processing","volume":"256","author":"R Zatorre","year":"1992","journal-title":"Science"},{"key":"pone.0251287.ref029","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/cercor\/11.10.946","article-title":"Spectral and temporal processing in human auditory cortex","volume":"11","author":"R Zatorre","year":"2001","journal-title":"Cereb Cortex"},{"issue":"8","key":"pone.0251287.ref030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3766\/jaaa.23.8.5","article-title":"Central presbycusis: a review and evaluation of the evidence","volume":"23","author":"L Humes","year":"2012","journal-title":"Journal of the American Academy of Audiology"},{"volume-title":"Acoustics Statistical Distribution of Hearing Thresholds as a Function of Age. ISO 7029","year":"2000","author":"International Organization for Standardization","key":"pone.0251287.ref031"},{"key":"pone.0251287.ref032","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness the Edinburgh inventory","volume":"9","author":"R Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"pone.0251287.ref033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/archotol.1970.04310040005002","article-title":"Clinical Experience with impedance audiometry","volume":"92","author":"J Jerger","year":"1970","journal-title":"Arch Otolaryng"},{"issue":"4","key":"pone.0251287.ref034","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA- A Brief Screening Tool for Mild Cognitive Impairment","volume":"53","author":"Z Nasreddine","year":"2005","journal-title":"Journal of American Geriatrics Society"},{"key":"pone.0251287.ref035","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/AUD.0b013e3181cdb272","article-title":"Auditory brainstem response to complex sounds: A tutorial","volume":"31","author":"E Skoe","year":"2010","journal-title":"Ear Hear"},{"key":"pone.0251287.ref036","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/01.aud.0000179687.71662.6e","article-title":"The brainstem response to speech: a biological marker of auditory processing","volume":"26","author":"KL Johnson","year":"2005","journal-title":"Ear Hearing"},{"issue":"4","key":"pone.0251287.ref037","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tins.2005.02.003","article-title":"Brainstem origins for cortical -what-and-where- pathways in the auditory system","volume":"28","author":"N Kraus","year":"2005","journal-title":"Trends Neuroscience"},{"issue":"3","key":"pone.0251287.ref038","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/AUD.0000000000000648","article-title":"Speech auditory brainstem responses: Effects of background, stimulus duration, consonant\u2013vowel, and number of epochs","volume":"40","author":"G BinKhamis","year":"2019","journal-title":"Ear and hearing"},{"key":"pone.0251287.ref039","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.clinph.2011.07.037","article-title":"Sex differences in auditory subcortical function","volume":"123","author":"J Krizman","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"pone.0251287.ref040","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/cercor\/bht311","article-title":"Stability and Plasticity of Auditory Brainstem Function Across the Lifespan","volume":"25","author":"E Skoe","year":"2015","journal-title":"Cerebral Cortex"},{"key":"pone.0251287.ref041","unstructured":"Skoe E, Nicol T, Kraus N. The Brainstem Toolbox. Version 2013. www.brainvolts.northwestern.edu."},{"key":"pone.0251287.ref042","first-page":"201","volume-title":"R: A language and environment for statistical computing","author":"Team, R. Core","year":"2020"},{"issue":"1","key":"pone.0251287.ref043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"D Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"issue":"4","key":"pone.0251287.ref044","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1076\/edre.7.4.353.8937","article-title":"A review of methods for missing data","volume":"7","author":"TD Pigott","year":"2001","journal-title":"Educational research and evaluation"},{"key":"pone.0251287.ref045","first-page":"231","volume-title":"The handbook of research synthesis","author":"R Rosenthal","year":"1994"},{"issue":"9","key":"pone.0251287.ref046","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/2041-210X.13434","article-title":"Robustness of linear mixed-effects models to violations of distributional assumptions","volume":"11","author":"H Schielzeth","year":"2020","journal-title":"Methods in Ecology and Evolution"},{"key":"pone.0251287.ref047","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2001.tb05728.x","article-title":"Intracerebral evoked potentials in pitch perception reveal a functional asymmetry of the human auditory cortex","volume":"930","author":"C Li\u00e9geois-Chauvel","year":"2001","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"pone.0251287.ref048","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/brain\/123.1.155","article-title":"Functional specificity in the right human auditory cortex for perceiving pitch direction","volume":"123","author":"I Johnsrude","year":"2000","journal-title":"Brain"},{"key":"pone.0251287.ref049","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00453473","article-title":"The dependence of early acoustically evoked potentials on age","volume":"240","author":"HS Johansen","year":"1984","journal-title":"Arch Otorhinolaryngol"},{"key":"pone.0251287.ref050","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1523\/JNEUROSCI.0012-08.2008","article-title":"Developmental plasticity in the human auditory brainstem","volume":"28","author":"K Johnson","year":"2008","journal-title":"J Neurosci"},{"key":"pone.0251287.ref051","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3940(99)00336-5","article-title":"Thalamic asymmetry is related to acoustic signal complexity","volume":"267","author":"C King","year":"1999","journal-title":"Neurosci Lett"},{"issue":"4","key":"pone.0251287.ref052","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ar.a.20295","article-title":"Differential Representation of Speech Sounds in the Human Cerebral Hemispheres","volume":"288","author":"J Firszt","year":"2006","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"pone.0251287.ref053","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-8760(01)00190-8","article-title":"Hemispheric asymmetries for visual and auditory temporal processing: an evoked potential study","volume":"44","author":"M Nicholls","year":"2002","journal-title":"International Journal of Psychophysiology"},{"issue":"5","key":"pone.0251287.ref054","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tics.2012.04.006","article-title":"Cortical asymmetries in speech perception: what\u2019s wrong, what\u2019s right, and what\u2019s left?","volume":"16","author":"C McGettigan","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"pone.0251287.ref055","first-page":"3116","volume-title":"The encyclopedia of language & linguistics","author":"J Gandour","year":"1994"},{"issue":"6","key":"pone.0251287.ref056","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1121\/1.3500675","article-title":"Effect of tonal native language on voice fundamental frequency responses to pitch feedback perturbations during sustained vocalizations","volume":"128","author":"H Liu","year":"2010","journal-title":"J Acoust Soc Am"},{"issue":"2","key":"pone.0251287.ref057","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/00437956.1957.11659634","article-title":"Functional aspects of Indian bilingualism","volume":"13","author":"U. Weinreich","year":"1957","journal-title":"Word"},{"issue":"1","key":"pone.0251287.ref058","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1353\/jhr.2014.0004","article-title":"Industrialization and bilingualism in India","volume":"49","author":"D. Clingingsmith","year":"2014","journal-title":"Journal of Human Resources"},{"issue":"2","key":"pone.0251287.ref059","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1086\/668277","article-title":"The returns to English-language skills in India","volume":"61","author":"M. Azam","year":"2013","journal-title":"Economic Development and Cultural Change"},{"key":"pone.0251287.ref060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bandl.2009.03.005","article-title":"The role of the auditory brainstem in processing linguistically-relevant pitch patterns","volume":"110","author":"A Krishnan","year":"2009","journal-title":"Brain Lang"},{"issue":"8","key":"pone.0251287.ref061","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/WNR.0b013e328353764d","article-title":"Experience-dependent plasticity in pitch encoding: from brainstem to auditory cortex","volume":"23","author":"A Krishnan","year":"2012","journal-title":"Neuroreport"},{"issue":"7","key":"pone.0251287.ref062","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.HJ.0000452246.45569.6a","article-title":"Bilingualism enhances neural speech encoding","volume":"67","author":"N Kraus","year":"2014","journal-title":"The Hearing Journal"},{"key":"pone.0251287.ref063","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuroscience.2017.02.049","article-title":"Basic neural processing of sound in adults is influenced by bilingual experience","volume":"349","author":"E Skoe","year":"2017","journal-title":"Neuroscience"},{"issue":"20","key":"pone.0251287.ref064","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.1201575109","article-title":"Subcortical encoding of sound is enhanced in bilinguals and relates to executive function advantages","volume":"109","author":"J Krizman","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pone.0251287.ref065","article-title":"Clinical applications of the auditory brainstem response","author":"L Hood","year":"1998","journal-title":"Singular"},{"issue":"1","key":"pone.0251287.ref066","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1044\/jshd.5101.63","article-title":"Latency and amplitude effects of electrode placement on the early auditory evoked response","volume":"51","author":"R Beattie","year":"1986","journal-title":"Journal of Speech and Hearing Disorder"},{"issue":"1","key":"pone.0251287.ref067","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000107432","article-title":"The effects of electrode montage on the amplitude of wave V in the auditory brainstem response to maximum length sequence stimuli","volume":"13","author":"A Dzulkarnain","year":"2008","journal-title":"Audiology and Neurotology"},{"key":"pone.0251287.ref068","first-page":"1180","article-title":"Effects of electrode position on tone-burst-evoked auditory brainstem responses (ABR) in humans","volume":"21","author":"A Dzulkarnain","year":"2014","journal-title":"Middle-East Journal of Scientific Research"},{"key":"pone.0251287.ref069","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.neurobiolaging.2011.12.015","article-title":"Musical experience offsets age-related delays in neural timing","volume":"33","author":"A Parbery-Clark","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"45","key":"pone.0251287.ref070","doi-asserted-by":"crossref","first-page":"17667","DOI":"10.1523\/JNEUROSCI.2560-13.2013","article-title":"Older Adults Benefit from Music Training Early in Life: Biological Evidence for Long-Term Training-Driven Plasticity","volume":"33","author":"T White-Schwoch","year":"2013","journal-title":"The Journal of Neuroscience"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T11:24:14Z","timestamp":1699010654000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251287"}},"subtitle":[],"editor":[{"given":"Paul Hinckley","family":"Delano","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0251287","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2021,5,7]]}}}