{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:37:31Z","timestamp":1784669851944,"version":"3.55.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960688;31360592"],"award-info":[{"award-number":["31960688;31360592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20181BAB204016"],"award-info":[{"award-number":["20181BAB204016"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Introduction<\/jats:title><jats:p>The intestinal structure is the foundation for various activities and functions in poultry. An important question concerns the changes in the intestinal status under endotoxin stimulation. This study aimed to investigate the mechanism of intestinal injury induced by lipopolysaccharide (LPS) in Wahui pigeons.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Thirty-six 28-day-old healthy Wahui pigeons were randomly divided into two groups. The experimental group was injected with LPS (100 \u03bcg\/kg) once per day for five days, and the control group was treated with the same amount of sterile saline. Blood and the ileum were collected from pigeons on the first, third, and fifth days of the experiment and used for oxidative stress assessment, inflammatory factor detection, histopathological examination, and positive cell localization. In addition, intestinal injury indices and mRNA expression levels (tight junction proteins, inflammatory cytokines, and factors related to autophagy and apoptosis) were evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Villi in the ileum were shorter in the LPS group than in the control group, and D-lactic acid levels in the serum were significantly increased. Glutathione and catalase levels significantly decreased, but the malondialdehyde content in the serum increased. TNF-\u03b1 and IL-10 were detected at higher levels in the serum, with stronger positive signals and higher mRNA expression levels, in the LPS group than in the control group. In addition, the levels of TLR4, MyD88, NF-\u03baB, and HMGB1 in the inflammatory signaling pathway were also upregulated. Finally, the mRNA expression of Claudin3, Occludin, and ZO-1 was significantly decreased; however, that of Beclin1 and Atg5 was increased in the LPS group.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Ileal pathological changes and oxidative stress were caused by LPS challenge; it is proposed that this triggering regulates the inflammatory response, causing excessive autophagy and apoptosis, promoting intestinal permeability, and leading to intestinal injury in Wahui pigeons.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0251462","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:46:22Z","timestamp":1620841582000},"page":"e0251462","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The influence on oxidative stress markers, inflammatory factors and intestinal injury-related molecules in Wahui pigeon induced by lipopolysaccharide"],"prefix":"10.1371","volume":"16","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youbao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-9387","authenticated-orcid":true,"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"pone.0251462.ref001","unstructured":"Valceschini EY. Poultry meat trends and consumer attitudes. Proc EPC 2006-12th European Poultry Conference, Verona, Italy. 2006; 10\u201314 September."},{"issue":"35","key":"pone.0251462.ref002","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1073\/pnas.0800445105","article-title":"Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach","volume":"105","author":"JW Jones","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"31","key":"pone.0251462.ref003","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"M Rosas-Ballina","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"pone.0251462.ref004","doi-asserted-by":"crossref","first-page":"e1800720","DOI":"10.1002\/mnfr.201800720","article-title":"Protective effect of proanthocyanidins in a rat model of mild intestinal inflammation and impaired intestinal permeability induced by LPS","volume":"63","author":"K Gil-Cardoso","year":"2019","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"pone.0251462.ref005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40348-016-0037-7","article-title":"Diverse roles of endoplasmic reticulum stress sensors in bacterial infection","volume":"3","author":"H Pillich","year":"2016","journal-title":"Molecular and Cellular Pediatrics"},{"issue":"2","key":"pone.0251462.ref006","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00000658-200002000-00015","article-title":"Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection","volume":"231","author":"A Goebel","year":"2000","journal-title":"Annals of Surgery"},{"key":"pone.0251462.ref007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40104-018-0275-8","article-title":"Effects of dietary Clostridium butyricum supplementation on growth performance, intestinal development, and immune response of weaned piglets challenged with lipopolysaccharide","volume":"9","author":"L Chen","year":"2018","journal-title":"J Anim Sci Biotechnol"},{"issue":"1","key":"pone.0251462.ref008","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41598-018-37296-x","article-title":"N-acetylcysteine modulates lipopolysaccharide-induced intestinal dysfunction","volume":"9","author":"SI Lee","year":"2019","journal-title":"Sci Rep"},{"issue":"7","key":"pone.0251462.ref009","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"M Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"pone.0251462.ref010","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1021\/acs.molpharmaceut.8b00332","article-title":"Metformin protects against LPS-induced intestinal barrier dysfunction by activating AMPK pathway","volume":"15","author":"WC Wu","year":"2018","journal-title":"Mol Pharm"},{"key":"pone.0251462.ref011","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2018.03.192","article-title":"Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes","volume":"204","author":"F Yang","year":"2018","journal-title":"Chemosphere"},{"key":"pone.0251462.ref012","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tiv.2018.10.017","article-title":"Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes","volume":"54","author":"F Yang","year":"2019","journal-title":"Toxicol in Vitro"},{"issue":"3","key":"pone.0251462.ref013","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1753425916632303","article-title":"L-Cysteine protects intestinal integrity, attenuates intestinal inflammation and oxidant stress, and modulates NF-\u03baB and Nrf2 pathways in weaned piglets after LPS challenge","volume":"22","author":"ZH Song","year":"2016","journal-title":"Innate Immunity"},{"key":"pone.0251462.ref014","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13578-015-0056-4","article-title":"NF-kappaB in inflammation and renal diseases","volume":"5","author":"H Zhang","year":"2015","journal-title":"Cell Biosci"},{"issue":"1","key":"pone.0251462.ref015","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-kappaB-microRNA regulatory network tunes macrophage inflammatory responses","volume":"8","author":"M Mann","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"pone.0251462.ref016","doi-asserted-by":"crossref","first-page":"a006049","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"K Newton","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"10","key":"pone.0251462.ref017","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1007\/s00464-016-4760-x","article-title":"Effect of bowel resection on TLR signaling during intestinal adaptation in a rat model","volume":"30","author":"I Sukhotnik","year":"2016","journal-title":"Surg Endosc"},{"issue":"7","key":"pone.0251462.ref018","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1017\/S0007114510005660","article-title":"Intestinal barrier function and absorption in pigs after weaning: a review","volume":"105","author":"PJA Wijtten","year":"2011","journal-title":"Br J Nutr"},{"issue":"2","key":"pone.0251462.ref019","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/physrev.00012.2006","article-title":"Restoration of barrier function in injured intestinal mucosa","volume":"87","author":"AT Blikslager","year":"2007","journal-title":"Physiol Rev"},{"issue":"2","key":"pone.0251462.ref020","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trsl.2006.12.010","article-title":"Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model","volume":"150","author":"HS Oz","year":"2007","journal-title":"Transl Res"},{"issue":"5","key":"pone.0251462.ref021","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jnutbio.2004.09.007","article-title":"Antioxidants as novel therapy in a murine model of colitis","volume":"16","author":"HS Oz","year":"2005","journal-title":"J Nutr Biochem"},{"issue":"11","key":"pone.0251462.ref022","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3945\/jn.112.164947","article-title":"Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge","volume":"142","author":"YL Liu","year":"2012","journal-title":"J Nutr"},{"issue":"2","key":"pone.0251462.ref023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","article-title":"Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14","volume":"182","author":"SH Guo","year":"2013","journal-title":"Am J Pathol"},{"key":"pone.0251462.ref024","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnut.2018.00060","article-title":"The well-developed mucosal immune systems of birds and mammals allow for similar approaches of mucosal vaccination in both types of animals","volume":"5","author":"T Nochi","year":"2018","journal-title":"Front Nutr"},{"key":"pone.0251462.ref025","first-page":"2945","article-title":"Advances in intestinal mucosal immunity provides an opportunity for traditional Chinese medicine immunity research","volume":"35","author":"L Zhou","year":"2019","journal-title":"Chin J Immunol"},{"issue":"3","key":"pone.0251462.ref026","doi-asserted-by":"crossref","first-page":"589","DOI":"10.24425\/124294","article-title":"Detection of IL-1\u03b2, IL-6 and TNF-\u03b1 in Sprague-Dawely rats\u2019atrophic thymus induced by lipopolysaccharide","volume":"21","author":"YB Zhong","year":"2018","journal-title":"Pol J Vet Sci"},{"issue":"6","key":"pone.0251462.ref027","first-page":"1019","article-title":"Skp2 expression exhibits a negative correlation with P27Kip1 in lungs of SD rat stress model induced by lipopolysaccharide","volume":"51","author":"YB Zhong","year":"2017","journal-title":"Indian J Anim Res"},{"issue":"7","key":"pone.0251462.ref028","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.semcdb.2012.03.014","article-title":"Intestinal redox biology and oxidative stress","volume":"23","author":"ML Circu","year":"2012","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"pone.0251462.ref029","first-page":"137","article-title":"Cryptdin-2 predicts intestinal injury during heatstroke in mice","volume":"41","author":"JJ Ji","year":"2018","journal-title":"Int J Mol Med"},{"issue":"10","key":"pone.0251462.ref030","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1023\/A:1026647024077","article-title":"Probiotic bacteria stimulate gut epithelial cell proliferation in rat","volume":"44","author":"H Ichikawa","year":"1999","journal-title":"Dig Dis Sci"},{"issue":"1","key":"pone.0251462.ref031","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2527\/2006.841125x","article-title":"Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acid-supplemented diets","volume":"84","author":"CM Nyachoti","year":"2006","journal-title":"J Anim Sci"},{"issue":"2","key":"pone.0251462.ref032","doi-asserted-by":"crossref","first-page":"77","DOI":"10.17221\/7981-VETMED","article-title":"Effect of Bacillus subtilis, Clostridium butyricum and lactobacillus acidophilus endospores on growth performance, nutrient digestibility, meat quality, relative organ weight, microbial shedding and excreta noxious gas emission in broilers","volume":"60","author":"MM Hossain","year":"2015","journal-title":"Vet Med-Czech"},{"issue":"2","key":"pone.0251462.ref033","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jss.2014.06.016","article-title":"Glycine selectively reduces intestinal injury during endotoxemia","volume":"192","author":"K Effenberger-Neidnicht","year":"2014","journal-title":"J Surg Res"},{"issue":"9","key":"pone.0251462.ref034","doi-asserted-by":"crossref","first-page":"e12969","DOI":"10.1371\/journal.pone.0012969","article-title":"Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-\u03baB activation","volume":"5","author":"WB Song","year":"2010","journal-title":"PLoS One"},{"key":"pone.0251462.ref035","first-page":"255","article-title":"Evaluation of intestinal barrier function after abdominal surgery by plasma D-lactic acid level","volume":"30","author":"QZ Li","year":"2005","journal-title":"Med J Chin PLA"},{"issue":"3","key":"pone.0251462.ref036","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00726-011-1191-9","article-title":"Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide","volume":"43","author":"YQ Hou","year":"2012","journal-title":"Amino Acids"},{"issue":"10","key":"pone.0251462.ref037","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"J Konig","year":"2016","journal-title":"Clin Transl Gastroen"},{"issue":"Pt 16","key":"pone.0251462.ref038","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1242\/jcs.065581","article-title":"Occludin is required for cytokine-induced regulation of tight junction barriers","volume":"123","author":"CM Van Itallie","year":"2010","journal-title":"J Cell Sci"},{"key":"pone.0251462.ref039","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40104-017-0159-3","article-title":"Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets","volume":"8","author":"H Vergauwen","year":"2017","journal-title":"J Anim Sci Biotechnol"},{"issue":"4","key":"pone.0251462.ref040","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"S Tsukita","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"pone.0251462.ref041","first-page":"274","article-title":"Current aspects of sepsis caused by bacterial translocation","volume":"137","author":"G Lamprecht","year":"2012","journal-title":"Zentralbl Chir"},{"issue":"7","key":"pone.0251462.ref042","doi-asserted-by":"crossref","first-page":"11621","DOI":"10.18632\/oncotarget.14598","article-title":"Matrine alleviates inflammation and oxidative stress via CCR7 signal intestinal","volume":"8","author":"GJ Wu","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"pone.0251462.ref043","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0891-5849(02)01081-X","article-title":"Extracellular thiol\/disulfide reddox state affects proliferation rate in a human colon carcinoma (Caco2) cell line","volume":"33","author":"CR Jonas","year":"2002","journal-title":"Free Radic Bio Med"},{"issue":"4","key":"pone.0251462.ref044","first-page":"e122893","article-title":"Effects of dietary supplementation with glutamate and aspartate on diquat-Induced oxidative stress in piglets","volume":"10","author":"J Yin","year":"2015","journal-title":"PLoS One"},{"issue":"Pt B","key":"pone.0251462.ref045","first-page":"2211","article-title":"The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice","volume":"107","author":"GH Mao","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"pone.0251462.ref046","doi-asserted-by":"crossref","first-page":"113873","DOI":"10.1016\/j.envpol.2019.113873","article-title":"Selenium prevent cadmium-induced hepatotoxicity through modulation of endoplasmic reticulum-resident selenoproteins and attenuation of endoplasmic reticulum stress","volume":"260","author":"C Zhang","year":"2020","journal-title":"Environ Pollut"},{"issue":"6","key":"pone.0251462.ref047","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3390\/ijms20061469","article-title":"The toxic effects and mechanisms of nano-Cu on the spleen of rats","volume":"20","author":"XR Zhou","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pone.0251462.ref048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/8954201","article-title":"Monoamine oxidase-related vascular oxidative stress in diseases associated with inflammatory burden","volume":"2019","author":"A Sturza","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"pone.0251462.ref049","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.4049\/jimmunol.181.6.4354","article-title":"Unique properties of the chicken TLR4\/MD-2 complex: selective lipopolysaccharide activation of the My D88-dependent pathway","volume":"181","author":"AM Keestra","year":"2008","journal-title":"Journal of Immunology"},{"key":"pone.0251462.ref050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.chemosphere.2018.06.165","article-title":"Oxidative stress-induced skeletal muscle injury involves in NF-kappaB\/p53-activated immunosuppression and apoptosis response in copper (II) or\/and arsenite-exposed chicken","volume":"210","author":"HJ Zhao","year":"2018","journal-title":"Chemosphere"},{"key":"pone.0251462.ref051","first-page":"55","article-title":"The role of TNF in inflammation","volume":"22","author":"BH Gao","year":"1999","journal-title":"Chin J Postgra Med"},{"issue":"Suppl 2","key":"pone.0251462.ref052","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.2337\/diabetes.54.suppl_2.S97","article-title":"Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities","volume":"54","author":"M Cnop","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"pone.0251462.ref053","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.immuni.2004.10.001","article-title":"Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction","volume":"21","author":"JR Muppidi","year":"2004","journal-title":"Immunity"},{"issue":"3","key":"pone.0251462.ref054","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cyto.2012.07.026","article-title":"Local and systemic occurrences of HMGB1 in gnotobiotic pigletsinfected with E.coli O55 are related to bacterial translocation and inflammatory cytokines","volume":"60","author":"A Splichalova","year":"2012","journal-title":"Cytokine"},{"key":"pone.0251462.ref055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.intimp.2017.10.007","article-title":"HMGB1 mediates Aspergillus fumigatus-induced inflammatory response in alveolar macrophages of COPD mice via activating MyD88\/NF-\u03baB and syk\/PI3K signalings","volume":"53","author":"PP Zhang","year":"2017","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"pone.0251462.ref056","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1159\/000485045","article-title":"High mobility group box l inhibitor Glycyrrhizic acid attenuates kidney injury in streptozotocin-induced diabetic rats","volume":"42","author":"H Zhang","year":"2017","journal-title":"Kidney Blood Press Res"},{"issue":"1","key":"pone.0251462.ref057","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s13046-019-1328-3","article-title":"HMGB1-mediated autophagy regulates sodium\/iodide symporter protein degradation in thyroid cancer cells","volume":"38","author":"WW Chai","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"3\u20134","key":"pone.0251462.ref058","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.vetimm.2013.01.013","article-title":"The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-kappaB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo","volume":"152","author":"YS Qiu","year":"2013","journal-title":"Vet Immunol Immunopathol"},{"key":"pone.0251462.ref059","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-230X-13-133","article-title":"Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model","volume":"13","author":"QJ Wang","year":"2013","journal-title":"BMC Gastroenterol"},{"issue":"13","key":"pone.0251462.ref060","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/emboj\/19.13.3325","article-title":"The apoptotic signaling pathway activated by Toll-like receptor-2","volume":"19","author":"AO Aliprantis","year":"2000","journal-title":"EMBO J"},{"issue":"3","key":"pone.0251462.ref061","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1172\/JCI0214774","article-title":"The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta","volume":"109","author":"DD Bannerman","year":"2002","journal-title":"J Clin Invest"},{"issue":"6980","key":"pone.0251462.ref062","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature02405","article-title":"The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4","volume":"428","author":"LC Hsu","year":"2004","journal-title":"Nature"},{"issue":"1","key":"pone.0251462.ref063","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1038\/s41598-018-32188-6","article-title":"Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury","volume":"8","author":"LX He","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0251462.ref064","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"M Karin","year":"2002","journal-title":"Nat immunol"},{"issue":"5","key":"pone.0251462.ref065","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.tcb.2006.03.008","article-title":"Apoptosis-inducing factor: vital and lethal","volume":"16","author":"N Modjtahedi","year":"2006","journal-title":"Trends Cell Biol"},{"issue":"1","key":"pone.0251462.ref066","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.immuni.2007.05.022","article-title":"Toll-like receptor 4 is a sensor for autophagy associated with innate immunity","volume":"27","author":"Y Xu","year":"2007","journal-title":"Immunity"},{"issue":"48","key":"pone.0251462.ref067","doi-asserted-by":"crossref","first-page":"33175","DOI":"10.1074\/jbc.M804478200","article-title":"MyD88 and TRIF target Beclin 1 to trigger autophagy in macrophages","volume":"283","author":"CS Shi","year":"2008","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0251462.ref068","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3748\/wjg.v17.i4.478","article-title":"Blocking NF-\u03baB nuclear translocation leads to p53-related autophagy activation and cell apoptosis","volume":"17","author":"BS Zhu","year":"2011","journal-title":"World J Gastroenterol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T19:23:58Z","timestamp":1725045838000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251462"}},"subtitle":[],"editor":[{"given":"Rosanna","family":"Di Paola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0251462","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]}}}